Zusammenfassung
Bei Patienten mit Thrombozytosen infolge von chronischen myeloproliferativen Erkrankung (CMPE), insbesondere bei Patienten mit essentieller Thrombozythämie (ETZ), Osteomyelofibrose (OMF) und Polycythaemia rubra vera (PRV), stellen hämorrhagische und thromboembolische Episoden typische Manifestationen dar, ohne daß gesagt werden kann, ob und welche Komplikationen sich im Einzelfall einstellen [8,9,15,22,23,27,28].
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Literatur
Alessi MC, Juhan-Vague I, Declerck PJ, Collen D (1991) Molecular forms of Plasminogen activator inhibitor-1 (PAI-1) and tissue-type Plasminogen activator (t-PA) in human plasma. Thromb Res 62:275–285
Bazaan M, Tamponi G, Stella S, Schinco PC, Pannocchia A, Pileri A (1993) Fibrinolytic imbalance in Essential Thrombocythemia: role of platelets. Haemostasis 23:138–44
Bellucci S, Ignatova E, Jaillet N, Boffa MC (1993) Platelet hyperactivation in patients with Essential Thrombocythemia is not associated with vascular endothelial cell damage as judged by the level of Plasma Thrombomodulin, Protein S, PAI-1, t-PA und vWF. Thromb Haemost 70,5:736–742
Booth NA, Simpson AJ, Croll A, Bennett B, MacGregor IR (1988) Plasminogen activator inhibitor (PAI-i) in plasma and platelets. Br J Haematol 70:327–333
Bridges AB, McLaren M, Scott NA, Pringle TH, McNeill GP, Belch JJF (1993) Circadian Variation of tissue Plasminogen activator and its inhibitor, von Willebrand factor antigen, and prostacyclin stimulating factor in men with ischaemic heart disease. Br Heart J 69:121–124
Cancelas JA, Garcia Avello A, Garcia Frade LJ (1994) High plasma levels of Plasminogen activator inhibitor 1 (PAI-i) in polycythemia vera and essential thrombocythemia are associated with thrombosis. Thromb Res 75:513–520
Cohen AM, Gelvan A, Kadouri A, Creter D, Djaldetti M (1990) Tissue Plasminogen Activator levels in different types of Polycythemia. Eur J Haematol 45:48–51
Colombi M, Radaelli F, Zocchi L, Maiolo AT (1991) Thrombotic and hemorrhagic complications in essential thrombocythemia. A retrospective study of 103 patients. Cancer 67:2926–2930
Cortelazzo S, Viero P, Finazzi G, D’Emilio A, Rodeghiero F, Barbui T (1990) Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia. J Clin Oncol 8:556–562
Craveri A, Tornaghi G, Ranieri R, Paganardi L (1990) Relations between overweight, thrombophilia and cardiovascular risk. Ann Ital Med Int 5:31–33
Dawson S, Henney A (1992) The status of PAI-i as a risk factor for arterial and thrombotic disease: a review. Atherosclerosis 95:105–117
Declerck PJ, Alessi MC, Verstreken M, Kruithof EKO, Juhan-Vague I, Collen D (1988) Measurement of Plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay. Blood 71:220–225
Fenaux P, Simon M, Caulier T, Lai JL, Goudemand J, Bauters F (1990) Clinical course of essential thrombocythemia in 147 cases. Cancer 66:549–556
Friedenberg WR, Roberts RC, David DE (1992) Relationship of thrombohemorrhagic complications to endothelial cell function in patients with chronic myeloproliferative disorders. Am J Hematol 40:283–289
Griesshammer M, Seifried E, Heimpel H (1993) Essentielle Thrombozythämie. Klinische Bedeutung, Diagnostik und Therapie. Dtsch Med Wochenschr 118:1412–1417
Hashimoto Y, Kobayashi A, Yamazaki N, Sugawara Y, Takada Y, Takada A (1987) Relationship between age and plasma t-PA, PA-Inhibitor and PA activity. Thromb Res 46,5:625–633
Koh S, Yuen R, Viegas O, Chue S, Ng B, Sen D, Ratnam S (1991) Plasminogen Activators t-PA, u-PA and its Inhibitor (PAI) in normal males and females. Thromb Haemost 66/5:581–585
Krishnamuturi C, Tang DB, Barr CF, Alving BM (1988) Plasminogen Activator and Plasminogen Activator Inhibitor activities in a reference population. Am J Clin Pathol 89:747–752
Kruithof EK, Gudinchet A, Bachmann F (1988) Plasminogen Activator Inhibitor 1 and Plasminogen Activator Inhibitor 2 in various disease states. Thromb Haemost 59,1:7–12
Lanir N, Brenner B, Tatarsky I (1992) Abnormalities of fibrinolytic parameters in patients with myeloproliferative diseases. Fibrinolysis 6:183–186
Lee MH, Vosburgh E, Anderson K, McDonagh J (1993) Deficiency of plasma Plasminogen activator inhibitor 1 results in hyperfibrinolytic bleeding. Blood 81:2357–2362
Mitus AJ, Schafer AI (1990) Thrombocytosis and thrombocythemia. Hematol Oncol Clin North Am 4:157–178
Randi ML, Stocco F, Rossi C, Tison T, Girolami A (1991) Thrombosis and hemorrhage in thrombocytosis: evaluation of a large cohort of patients (357 cases). J Med 22:213–223
Simpson AJ, Booth NA, Moore NR, Bennett B (1990) The platelet and plasma pools of Plasminogen activator inhibitor (PAI-1) vary independently in disease. Br J Haematol 75:543–548
Sloan IG, Firkin BG (1989) Impaired fibrinolysis in patients with thrombotic or haemostatic defects. Thromb Res 55:559–567
Tanimura LK, Weddell JA, McKown CG, Shapiro AD, Mulherin J (1994) Oral management of a patient with a plasminogen activator inhibitor (PAI-1) deficiency: case report. Pediatr Dent 16:133–135
VanGenderen PJ, Michiels JJ (1994) Erythromelalgic, thrombotic and haemorrhagic manifestations of thrombocythaemia. Presse Med 23:73–77 (Abstract)
Wehmeier A, Daum I, Jamin H, Schneider W (1991) Incidence and clinical risk factors for bleeding and thrombotic complications in myeloproliferative disorders. Ann Hematol 63:101–106
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Schiemann, M., Depka Prondzinski, M., Stoll, H., Scharrer, I. (1997). PAI-1 und t-PA bei Patienten mit Thrombozytosen im Rahmen von chronischen myeloproliferativen Erkrankungen. In: 26. Hämophilie-Symposion 1995. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60418-8_51
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DOI: https://doi.org/10.1007/978-3-642-60418-8_51
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