Skip to main content
SpringerLink
Log in

Interferons in Kaposi’s Sarcoma

  • Conference paper
Interferons

  • 97 Accesses

Abstract

Kaposi’s sarcoma (KS) is a mesenchymal tumour of unclear etiopathogenesis involving blood and lymphatic vessels which was first investigated by Moritz Kaposi in 1872 [2]. Moritz Kaposi described a disease that was and is diagnosed very rarely, predominantly in elderly men in eastern European countries. This so-called classical form of KS typically involves the lower extremities and very seldom visceral organs. The tumours grow slowly, sometimes over many years, from flat purple plaques to nodular lesions involving adjacent lymph nodes [1, 3]. Throughout the past few years much knowledge of the epidemiology and pathogenesis of KS has been gained.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Buchbinder A, Friedman-Kien AE (1992) Clinical aspects of Kaposi’s sarcoma. Curr Opin Oncol 4: 867–874

    Article  PubMed  CAS  Google Scholar 

  2. Kaposi M (1872) Idiopathisches multiples Pigmentsarkom der Haut. Arch Derm Syph 4: 742–749

    Article  Google Scholar 

  3. Friedman-Kien AE, Saltzman BR (1990) Clinical manifestations of classical, endemic African, and epidemic AIDS-associated Kaposi’s sarcoma. J Am Acad Dermatol 22: 1237–1250

    Article  PubMed  CAS  Google Scholar 

  4. Ziegler JL, Templeton AC, Vogel CL (1984) Kaposi’s sarcoma: a comparison of classical, endemic and epidemic forms. Semin Oncol 11: 47–52

    PubMed  CAS  Google Scholar 

  5. Klepp 0, Dahl O, Stenwig JT (1978) Association of Kaposi’s sarcoma and prior immunosuppressive therapy: a 5-year material of Kaposi’s sarcoma in Norway. Cancer 42: 2626–2630

    Article  PubMed  Google Scholar 

  6. Friedman-Kien AE (1981) Disseminated Kaposi’s sarcoma syndrome in young homosexual men. J Am Acad Dermatol 5: 468–471

    Article  PubMed  CAS  Google Scholar 

  7. Friedman-Kien AE, Laubenstein LJ, Rubinstein P et al (1982) Disseminated Kaposi’ sarcoma in homosexual men. Ann Intern Med 6: 693–700

    Google Scholar 

  8. Mamor M, Friedman-Kien AE, Laubenstein LJ et al (1982) Risk factors for Kaposi’ sarcoma in homosexual men. Lancet 1: 1083–1087

    Article  Google Scholar 

  9. Pitchenik AE, Fischl MA, Dickinson GM et al (1983) Opportunistic infections and Kaposi’ sarcoma among Haitians: evidence of a new acquired immunodeficiency state. Ann Intern Med 98: 277–284

    PubMed  CAS  Google Scholar 

  10. Friedman-Kien AE, Saltzman BR, Cao Y et al (1990) Kaposi’ sarcoma in HIV-negative homosexual men. Lancet 335: 168–169

    Article  PubMed  CAS  Google Scholar 

  11. Mitsuyasu RT, Groopman JE (1984) Biology and therapy of Kaposi’s sarcoma. Semin Oncol 11: 53–59

    PubMed  CAS  Google Scholar 

  12. Templeton AC (1981) Kaposi’s sarcoma. Pathol Annu 16: 315–336

    PubMed  CAS  Google Scholar 

  13. Friedman-Kien AE, Ostreicher R, Saltzman B (1989) Clinical manifestations of classical, endemic African, and epidemic AIDS-associated Kaposi’s sarcoma. In: Friedman-Kien AE (ed) Color Atlas of AIDS. Saunders, Philadelphia, pp 11–48

    Google Scholar 

  14. Reynolds WA, Winkelmann RK, Soule EH (1965) Kaposi’s sarcoma: a clinicopathologic study with particular reference to its relationship to the reticuloendothelial system. Medicine 44: 419–423

    Article  PubMed  CAS  Google Scholar 

  15. Templeton AC (1988) Pathology. In: Ziegler JL, Dorfman RF (eds) Kaposi’s sarcoma: Pathophysiology and Clinical management. Dekker, New York, pp 23–70

    Google Scholar 

  16. Kaloterakis A, Papasterindes C, Filiotou A, Economidou J, Hadjiyannis S, Stratigos J (1995) HLA in familial and nonfamilial Mediterranean Kaposi’s sarcoma in Greece. Tissue Antigens 45: 117–119

    Article  PubMed  CAS  Google Scholar 

  17. Modlin RL, Hofman FM, Kempf RA, Taylor CR, Conant HA, Rea TH (1983) Kaposis’s sarcoma in homosexual men: an immunohistological study. J Am Acad Dermatol 8: 620–627

    Article  PubMed  CAS  Google Scholar 

  18. Stein RG, Longo DL (1988) Clinical, biological and therapeutic aspects of malignancies associated with the aquired immunodeficiency syndrome: Part I/II. Ann Allergy 60: 310–323

    Google Scholar 

  19. Richman SP, Vogel CL (1988) Kaposi’s sarcoma. In: Brain MC, Carbone PP (eds) Current Therapy in Hematology-Oncology-3, Current Therapy Series. Decker, Toronto, pp 353–355

    Google Scholar 

  20. Hutt MSR (1981) The epidemiology of Kaposi’s sarcoma. Antibiot Chemother 29: 3–11

    PubMed  CAS  Google Scholar 

  21. Kestens L, Melbye M, Biggar RH et al (1985) Endemic African Kaposi’s sarcoma is not associated with immunodeficiency. Int J Cancer 36: 49–54

    Article  PubMed  CAS  Google Scholar 

  22. Rybojad M, Borradori L, Verola O, Zeller J, Puissant A, Morel P (1990) Non-AIDS-associated Kaposi’s sarcoma (classical and endemic African types): treatment with low doses of recombinant interferon-alpha. J Invest Dermatol 95 [Suppl]: 176–179

    Google Scholar 

  23. Penn I (1978) Secondary neoplasms as a consequence of transplantation and cancer therapy. Cancer Detect Prev 12: 39–57

    Google Scholar 

  24. Gange TW, Jones EW (1978) Kaposi’s sarcoma and immunosuppressive therapy: an appraisal. Clin Exp Dermatol 3: 135–146

    Article  PubMed  CAS  Google Scholar 

  25. Penn I (1988) Etiology: immunodeficiency. In: Ziegler JL, Dorfman RF (eds) Kaposi’s sarcoma: Pathophysiology and Clinical management. Dekker, New York, pp 129–150

    Google Scholar 

  26. Erban SB, Sokas RK (1988) Kaposi’s sarcoma in an elderly man with Wegener’s granulomatosis treated with cyclophosphamide and corticosteroids. Arch Intern Med 148: 1201–1203

    Article  PubMed  CAS  Google Scholar 

  27. Quinibi W, Akhtar M, Sheth K et al (1988) Kaposi’s sarcoma: the most common tumor after renal transplant in Saudi Arabia. Am J Med 84: 225–232

    Article  Google Scholar 

  28. Porta F, Bongiorno M, Locatelli F et al (1991) Kaposi’s sarcoma in a child after autologous bone marrow transplantation for non-Hodgkin’s lymphoma. Cancer 68: 1361–1364

    Article  PubMed  CAS  Google Scholar 

  29. Miles SA (1994) Pathogenesis of HIV-related Kaposi’s sarcoma. Curr Opin Oncol 6: 497–502

    Article  PubMed  CAS  Google Scholar 

  30. Ensoli B, Barillari G, Gallo RC (1991) Pathogenesis of AIDS-associated Kaposi’s sarcoma. Hematol Oncol Clin North Am 5: 281–295

    PubMed  CAS  Google Scholar 

  31. Haverkos HW, Drotman DP, Hanson D (1993) Epidemiology of AIDS-related Kaposi’s sarcoma (KS): an update. Int Conf AIDS 9: 398

    Google Scholar 

  32. Schlechter MT, Marion SA, Elsmlie KD, Ricketts MN, Nault P, Archibald CP (1991) Geographic and birth cohort associations of Kaposi’s sarcoma among homosexual men in Canada. Am J Epidemiol 134: 485–488

    Google Scholar 

  33. Kaldor JM, Tindali B, Williamson P, Ellford J, Cooper DA (1993) Factors associated with Kaposi’s sarcoma in a cohort of homosexual and bisexual men. J Aquir Immune Defic Syndr 6: 1145–1149

    CAS  Google Scholar 

  34. Gill PS (1991) Pathogenesis of HIV-related malignancies. Curr Opin Oncol 3: 867–871

    Article  PubMed  CAS  Google Scholar 

  35. Miles SA (1992) Pathogenesis of human immunodeficiency virus-related Kaposi’s sarcoma. Curr Opin Oncol 4: 875–882

    Article  PubMed  CAS  Google Scholar 

  36. Albini A, Barillari G, Benelli R, Gallo RC, Ensoli B (1995) Angiogenic properties of human immunodeficiency virus type 1 Tat protein. Proc Natl Acad Sci USA 2392: 4838–4842

    Article  Google Scholar 

  37. Ensoli B, Gendelman R, Markham P et al (1994) Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi’s sarcoma. Nature 371: 674–680

    Article  PubMed  CAS  Google Scholar 

  38. Maitra RK, McMillan NA, Desai S et al (1994) HIV-1 TAT RNA has an intrinsic ability to activate interferon-inducible enzymes. Virology 204: 823–827

    Article  PubMed  CAS  Google Scholar 

  39. Wang CY, Schroeter AL, Su WP (1995) Acquired immunodeficiency syndrome-related Kaposi’s sarcoma. Mayo Clin Proc 70: 869–879

    Article  PubMed  CAS  Google Scholar 

  40. Samaniego F, Markham PD, Gallo RC, Ensoli B (1995) Inflammatory cytokines induce AIDS-Kaposi’s sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi’s sarcoma-like lesion formation in nude mice. J Immunol 154: 3582–3592

    PubMed  CAS  Google Scholar 

  41. Ndimbie OK, Kingsley L, Piper M, Rinaldo C Jr, Virji M (1995) Longitudinal assessment of basic fibroblast growth factor levels in homosexual men with Kaposi’s sarcoma. Natl Conf Hum Retroviruses Relat Infect (2nd) Jan 29-Feb 2, 1995, 84

    Google Scholar 

  42. Sturzl M, Brandstetter H, Roth WK (1992) Kaposi’s sarcoma: a review of gene expression and ultrastructure of KS spindle cells in vivo. AIDS Res Hum Retroviruses 18: 1753–1763

    Article  Google Scholar 

  43. Williams AO, Ward JM, Li JF, Jackson MA, Flanders KC (1995) Immunohistochemical localization of transforming growth factor-beta 1 in Kaposi’s sarcoma. Hum Pathol 26: 469–473

    Article  PubMed  CAS  Google Scholar 

  44. Ensoli B, Barillari G, Gallo RC (1992) Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi’s sarcoma. Immunol Rev 127: 147–155

    Article  PubMed  CAS  Google Scholar 

  45. Chang Y, Cesarman E, Pessin MS et al (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 266: 1865–1869

    Article  PubMed  CAS  Google Scholar 

  46. Ambroziak JA, Blackbourn DJ, Herndier BG et al (1995) Herpes-like sequences in HIV-infected and uninfected Kaposi’s sarcoma patients. Science 268: 582–583

    Article  PubMed  CAS  Google Scholar 

  47. Boshoff C, Whitby D, Hatziioannou T et al (1995) Kaposi’-sarcoma-associated herpesvirus in HIV-negative Kaposi’s sarcoma. Lancet 345: 1043–1044

    Article  PubMed  CAS  Google Scholar 

  48. Moore PS, Chang Y (1995) Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma in patients with and without HIV infection. N Engl J Med 332: 1181–1185

    Article  PubMed  CAS  Google Scholar 

  49. Dupin N, Grandadam M, Calvez V et al (1995) Herpesvirus-like DNA sequences in patients with mediterranean Kaposi’s sarcoma. Lancet 345: 761–762

    Article  PubMed  CAS  Google Scholar 

  50. Huang YQ, Li JJ, Kaplan MH et al (1995) Human herpesvirus-like nucleic acid in various forms of Kaposi’s sarcoma. Lancet 345: 759–761

    Article  PubMed  CAS  Google Scholar 

  51. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM (1995) Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332: 1186–1191

    Article  PubMed  CAS  Google Scholar 

  52. Soulier J, Grollet L, Oksenhendler E et al (1995) Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman’s disease. Blood 86: 1276–1280

    PubMed  CAS  Google Scholar 

  53. Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y (1995) In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-i and BC-2) containing Kaposi’s sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 86: 2708–2714

    PubMed  CAS  Google Scholar 

  54. Kempf W, Adams V, Pfaltz M et al (1995) Human herpesvirus type 6 and cytomegalovirus in AIDS-associated Kaposi’s sarcoma: no evidence for an etiological association. Hum Pathol 26: 914–919

    Article  PubMed  CAS  Google Scholar 

  55. Scinicariello F, Dolan MJ, Nedelcu I, Tyring SK, Hilliard JK (1994) Occurrence of human papillomavirus and p53 gene mutations in Kaposi’s sarcoma. Virology 203: 153–157

    Article  PubMed  CAS  Google Scholar 

  56. Soderberg LS, Barnett JB (1995) Inhalation exposure to isobutyl nitrite inhibits macrophage tumoricidal activity and modulates inducible nitric oxide. J Leukoc Biol 57: 135–140

    PubMed  CAS  Google Scholar 

  57. Christeff N, Winter C, Gharakhanian S et al (1995) Differences in androgens of HIV positive patients with and without Kaposi sarcoma. J Clin Pathol 48: 513–518

    Article  PubMed  CAS  Google Scholar 

  58. Guo WX, Antakly (1995) AIDS-related Kaposi’s sarcoma: evidence for direct stimulatory effect of glucocorticoid on cell proliferation. Am J Pathol 146: 727–734

    PubMed  CAS  Google Scholar 

  59. Tambussi G, Repetto L, Torri V et al (1995) Epidemic HIV-related Kaposi’s sarcoma: a retrospective analysis and validation of TIS staging. GICAT. Gruppo Italiano Collaborativo AIDS e Tumori. Ann Oncol 6: 383–317

    PubMed  CAS  Google Scholar 

  60. Krickeberg H, Rasokat H (1990) Survival pattern and response to therapy in 104 patients with HIV-related Kaposi’s sarcoma. Int Conf AIDS, Jun 16–21, 1991; 7(1): 78 (abstract no. TU.B.84)

    Google Scholar 

  61. Padiglione A, Goldstein D, Law M, Kaldor J, Hoy J, Mijch A (1994) Prognosis of Kaposi’s sarcoma as a primary and secondary AIDS defining illness. Annu Conf Australas Soc HIV Med 6: 109

    Google Scholar 

  62. Schymura MJ, Smith PF, Chiasson MA, Fordyce EJ (1995) The epidemiology of AIDS-associated Kaposi’s sarcoma (KS) among women in New York State (NYS). HIV Infect Women 22–24: S31

    Google Scholar 

  63. Albrecht H, Helm EB, Plettenberg A, et al (1994) Kaposi’s sarcoma in HIV infected women in Germany: more evidence for sexual transmission. A report of 10 cases and review of the literature. Genitourin Med 70: 394–398

    PubMed  CAS  Google Scholar 

  64. Szelenyi H, Jablonowski H, Armbrecht C, Mauss S, Niederau C, Strohmeyer G (1993) Long term treatment with liposomal doxorubicin in patients with AIDS-related Kaposi’s sarcoma. Int Conf AIDS Jun 6–11, 1993; 9(1): 397 (abstract no. PO-B12–1574)

    Google Scholar 

  65. Flaitz CM, Nichols CM, Hicks MJ (1995) An overview of the oral manifestations of AIDS-related Kaposi’s sarcoma. Compendium Feb, 1995; 6: 136–138

    Google Scholar 

  66. Mocroft A, Phillips A, Sabin C, Janossy G, Lee C, Johnson M (1995) A proposed staging system for clinical AIDS patients. Natl Conf Hum Retroviruses Relat Infect (2nd) Jan 29-Feb 2, 1995; p 157

    Google Scholar 

  67. Jablonowski H, Szelenyi H, Armbrecht C, Mauss S, Niederau C, Strohmeyer G (1993) Liposomal doxorubicin - a new formulation for the treatment of Kaposi’s sarcoma: a study on safety and efficacy in AIDS patients. Int Conf AIDS, Jun 6–11, 1993; 9(1): 397 (abstract no. PO-B12–1573)

    Google Scholar 

  68. Pluda JM, Parkinson DR, Feigal E, Yarchoan R (1993) Noncytotoxic approaches to the treatment of HIV-associated Kaposi’s sarcoma. Oncology (Huntingt) 7: 25–33

    CAS  Google Scholar 

  69. De Stefano E, Friedman RM, Friedman-Kien AE et al (1982) Acid-labile human leukocyte interferon in homosexual men with Kaposi’s sarcoma and lymphadenopathy. J Infect Dis 146: 451–459

    Article  Google Scholar 

  70. Lopez G, Fitzgerald PA, Siegal FP (1983) Severe acquired immune deficiency syndrome in male homosexuals: diminished capacity to make interferon-alpha in vitro associated with severe opportunistic infections. J Infect Dis 148: 962–966

    Article  PubMed  CAS  Google Scholar 

  71. Krown SE, Real FX, Cunningham-Rundles S et al (1983) Preliminary observations on the effect of recombinant leukocyte A interferon in homosexual men with Kaposi’s sarcoma. N Engl J Med 308: 1071–1076

    Article  PubMed  CAS  Google Scholar 

  72. Groopman JE, Gottlieb MS, Goodman J et al (1984) Recombinant alpha-2 interferon therapy for Kaposi’s sarcoma associated with the acquired immunodeficiency syndrome. Ann Intern Med 100: 671–676

    PubMed  CAS  Google Scholar 

  73. Rios A, Mansell PW, Newell GR, Reuben JM, Hersh EM, Gutterman JU (1985) Treatment of acquired immunodeficiency syndrome-related Kaposi’s sarcoma with lymphoblastoid interferon. J Clin Oncol 3: 506–512

    PubMed  CAS  Google Scholar 

  74. Real FX, Oettgen HF, Krown SE (1986) Kaposi’s sarcoma and the acquired immunodeficiency syndrome: treatment with high and low doses of recombinant leukocyte A interferon. J Clin Oncol 4: 544–551

    PubMed  CAS  Google Scholar 

  75. Volberding PA, Mitsuyasu RT, Golando JP, Spiegel RJ (1987) Treatment of Kaposi’s sarcoma with interferon alfa-2b (Intron A). Cancer 59 [Suppl 3]: 620–625

    Article  PubMed  CAS  Google Scholar 

  76. Krown SE, Real FX, Vadhan-Raj S et al (1986) Kaposi’s sarcoma and the acquired immune deficiency syndrome. Treatment with recombinant interferon alpha and analysis of prognostic factors. Cancer 57 [Suppl 8]: 1662–1665

    Article  PubMed  CAS  Google Scholar 

  77. Rozenbaum W, Tabah I, Gharakhanian S, Cardon B, Bideault HAT (1991) Randomized study of 3 different dosages of interferon (INF) alpha 2 B for well-responding AIDS-related Kaposi’s sarcoma (KS). Int Conf AIDS, Jun 16–21, 1991; 7 (2): 275 (abstract no. W.B.2374)

    Google Scholar 

  78. Baca-Regen L, Heinzinger N, Stevenson M, Gendelman HE (1994) Alpha interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type i-infected monocytes. J Virol 68: 7559–7565

    PubMed  CAS  Google Scholar 

  79. Shirazi Y, Popik W, Pitha PM (1994) Modulation of interferon-mediated inhibition of human immunodeficiency virus type 1 by Tat. J Interferon Res 14: 259–263

    Article  PubMed  CAS  Google Scholar 

  80. Tissot C, Mechti N (1995) Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression. J Biol Chem 270: 14891–14898

    Article  PubMed  CAS  Google Scholar 

  81. Ohashi K, Akazawa R, Kurimoto M (1994) Interferon-alpha augments interleukin-8 release from latently HlV-1-infectedmonocyticcellline, U937cells.Int Conf AIDS, Aug 7–12, 1994; 10 (2) 199 (abstract no. PA0275)

    Google Scholar 

  82. Mitsuyasu RT (1989) The enhanced potential use of recombinant alpha interferon in the treatment of AIDS-related Kaposi’s sarcoma. Oncol Nurs Forum 16 [Suppl 6]: 5–7

    PubMed  CAS  Google Scholar 

  83. Krown SE, Gold JW, Niedzwiecki D et al (1990) Interferon-alpha with zidovudine: safety, tolerance, and clinical and virologic effects in patients with Kaposi sarcoma associated with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 112: 812–821

    PubMed  CAS  Google Scholar 

  84. Gonzalez-Canali G, Louvet C, Navarro-Carrola E et al (1990) Survival of 30 patients with AIDS related Kaposi’s sarcoma (KS) treated with AZT and alpha 2 A interferon (IFN). Int Conf AIDS, Jun 20–23, 1990; 6 (3): 214 (abstract no. S.B.515)

    Google Scholar 

  85. Fischl MA, Uttamchandani RB, Resnick L et al (1984) A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n 1 and concomitant zidovudine in patients with AIDS-related Kaposi’s sarcoma.

    Google Scholar 

  86. Gill PS, Rarick MU, Bernstein-Singer M et al (1990) Interferon-alpha maintenance therapy after cytotoxic chemotherapy for treatment of acquired immunodeficiency syndrome-related Kaposi’s sarcoma. J Biol Response Mod 9: 512–516

    PubMed  CAS  Google Scholar 

  87. Rozenbaum W, Gharakhanian S, Navarette MS, De Sahb R, Cardon B, Rouzioux C (1990) Long-term follow-up of 120 patients with AIDS-related Kaposi’s sarcoma treated with interferon alpha-2a. J Invest Dermatol 95 [Suppl 6]: 161S-165S

    Article  PubMed  CAS  Google Scholar 

  88. Abrams DI, Volberding PA (1986) Alpha interferon therapy of AIDS-associated Kaposi’s sarcoma. Semin Oncol 13 [3 Suppl 2]: 43–47

    PubMed  CAS  Google Scholar 

  89. Kern P, Meigel W, Racz P, Gottesleben A, Dettke T, Dietrich M (1987) Interferon alpha in the treatment of AIDS-associated Kaposi’s sarcoma. Onkologie 10: 50–52

    Article  PubMed  CAS  Google Scholar 

  90. Shepherd FA, Evans WK, Garvey B (1988) Combination chemotherapy and alpha-interferon in the treatment of Kaposi’s sarcoma associated with acquired immune deficiency syndrome. Can Med Assoc J 139: 635–639

    CAS  Google Scholar 

  91. Krigel RL, Slywotzky CM, Lonberg M et al (1988) Treatment of epidemic Kaposi’s sarcoma with a combination of interferon-alpha 2b and etoposide. J Biol Response Mod 7: 359–364

    PubMed  CAS  Google Scholar 

  92. Krown SE (1987) The role of interferon in the therapy of epidemic Kaposi’s sarcoma. Semin Oncol 14 [2 Suppl 3]: 27–33

    PubMed  CAS  Google Scholar 

  93. Real FX, Krown SE, Nisce LZ, Oettgen HF (1985) Unexpected toxicity from radiation therapy in two patients with Kaposi’s sarcoma receiving interferon. J Biol Response Mod 4: 141–146

    PubMed  CAS  Google Scholar 

  94. Gelmann EP, Preble OT, Steis R et al (1985) Human lymphoblastoid interferon treatment of Kaposi’s sarcoma in the acquired immune deficiency syndrome. Clinical response and prognostic parameters. Am J Med 78: 737–741

    Article  PubMed  CAS  Google Scholar 

  95. Brennan C (1991) The use of interferon alpha with antiretrovirals in AIDS patients with Kaposi’s sarcoma and low T4 cell counts. Int Conf AIDS, Jun 16–21, 1991; 7 (2): 215 (abstract no. W.B.2133)

    Google Scholar 

  96. Mitsuyasu RT, Taylor JM, Glaspy J, Fahey JL (1986) Heterogeneity of epidemic Kaposi’s sarcoma. Implications for therapy. Cancer 57 [Suppl 8]: 1657–1661

    Article  PubMed  CAS  Google Scholar 

  97. Szlavik J, Banhegyi D, Miskovits E, Gerlei Z (1993) Recombinant interferon-alfa treatment in advanced KS and chronic HBV hepatitis associated with HIV infection. Int Conf AIDS, Jun 6–11, 1993; 9 (1): 401 (abstract no. PO-B12–1595)

    Google Scholar 

  98. Beaulieu R, Shepherd F, Murphy K et al (1994) A randomized trial of 2 doses of alpha interferon (IFN) added to AZT for the treatment of Kaposi’s sarcoma. Int Conf AIDS, Aug 7–12, 1994; 10 (1): 174 (abstract no. PB0122)

    Google Scholar 

  99. Rosenthal E, Pesce A, Vinti H, Reboulot B, Hoffman P, Cassuto JP (1993) Isotretinoin plus interferon alpha-2a in AIDS-related Kaposi’s sarcoma. Int Conf AIDS, Jun 6–11, 1993; 9 (1): 403 (abstract no. PO-B12–1607)

    Google Scholar 

  100. Schmilovich A, Perez H, Cahn P, Gil Deza E, Grinberg N, Casiro A (1993) Recombinant interferon alpha 2b (r IFN alpha2b +/- zidovudine (AZT) in low risk epidemic Kaposi’s sarcoma (EKS). Natl Conf Hum Retroviruses Relat Infect (1st), Dec 12–16, 1993; p 146

    Google Scholar 

  101. Shepherd F, Sawka C, Beaulieu R, Thout C, Murphy K, Gelmon K (1993) A randomized open label trial of two doses of alpha interferon added to AZT for the treatment of HIV-associated Kaposi’s sarcoma. Int Conf AIDS (Germany), Jun 6–11, 1993; 9 (1): 400 (abstract no. PO-B12–1587)

    Google Scholar 

  102. Opravil M, Hodapp K, Luthy R (1994) Interferon alpha-2a + zidovudine vs. bleomycin + zidovudine for HIV-associated Kaposi’s sarcoma. The Swiss Group for Clinical Studies on AIDS. Int Conf AIDS, Aug 7–12, 1994; 10 (1): 179 (abstract no. PB0141)

    Google Scholar 

  103. Podzamczer D, Bolao F, Clotet B et al (1993) Low-dose interferon alpha combined with zidovudine in patients with AIDS-associated Kaposi’s sarcoma. J Intern Med 233: 247–253

    Article  PubMed  CAS  Google Scholar 

  104. Mauss S, Szelenyi H, Jablonowski H (1994) Current therapeutic strategies in AIDS-associated Kaposi sarcoma. An overview including results of a personal study. Med Klin 89: 550–555

    CAS  Google Scholar 

  105. Mauss S, Jablonowski H (1995) Efficacy, safety and tolerance of low-dose, long-term interferon-alpha 2b and zidovudine in early-stage AIDS-associated Kaposi’s sarcoma. J Acquir Immune Defic Syndr 2: 157–162

    Google Scholar 

  106. Logan DM, Patenaude P, Filion LG (1993) Differential effect of chemotherapeutic agents on two epidemic Kaposi’s sarcoma cell lines. Natl Conf Hum Retroviruses Relat Infect (1 st) Dec 12–16, 1993; p 144

    Google Scholar 

  107. Ioachim HL, Adsay V, Giancotti FR, Dorsett B, Melamed J (1995) Kaposi’s sarcoma of internal organs. A multiparameter study of 86 cases. Cancer 75: 1376–1385

    Article  PubMed  CAS  Google Scholar 

  108. Hartshorn KL, Neumeyer D, Vogt MW, Schooley RT, Hirsch MS (1987) Activity of interferons alpha, beta, and gamma against human immunodeficiency virus replication in vitro. AIDS Res Hum Retroviruses 3: 125–133

    Article  PubMed  CAS  Google Scholar 

  109. Oka S, Hirabayashi Y, Mouri H et al (1989) Beta-interferon and early stage HIV infection. J Acquir Immune Defic Syndr 2: 125–128

    PubMed  CAS  Google Scholar 

  110. Miles SA, Wang HJ, Cortes E, Carden J, Marcus S, Mitsuyasu RT (1990) Beta-interferon therapy in patients with poor-prognosis Kaposi sarcoma related to the acquired immunodeficiency syndrome (AIDS). A phase II trial with preliminary evidence of antiviral activity and low incidence of opportunistic infections. Ann Intern Med 112: 582–589

    PubMed  CAS  Google Scholar 

  111. Brockmeyer NH, Mertins L, Daecke C, Goos M (1989) Regression of Kaposi’s sarcoma and improvement of performance status by a combined interferon beta and zidovudine therapy in AIDS patients. J Invest Dermatol 92: 776

    Article  PubMed  CAS  Google Scholar 

  112. Knechten H, Breeck F (1989) Remission of Kaposi-sarcoma by a combined therapy with interferon-beta + AZT in an AIDS patient. Int Conf AIDS Jun 4–9, 1989; 5: 335 (abstract no. T.B.P.291)

    Google Scholar 

  113. Stavermann T, Hubner P, Ruess A (1992) Recombinant interferon-beta in the therapy of advanced AIDS-related Kaposi’s sarcoma. Int Conf AIDS, Jul 19–24, 1992; 8 (2): B108 (abstract no. PoB 3126)

    Google Scholar 

  114. Krigel RL, Padavic-Shaller KA, Rudolph AR, Poiesz BJ, Comis RL (1989) Exacerbation of epidemic Kaposi’s sarcoma with a combination of interleukin-2 and beta-interferon: results of a phase 2 study. J Biol Response Mod 8: 359–365

    PubMed  CAS  Google Scholar 

  115. Brockmeyer NH, Mertins L, Goos M (1990) Progression of Kaposi’s sarcoma under a combined interferon beta and interferon gamma therapy in AIDS patients. Klin Wochenschr 68: 1229

    Article  PubMed  CAS  Google Scholar 

  116. Krigel RL, Odajnyk CM, Laubenstein LJ et al (1985) Therapeutic trial of interferon-gamma in patients with epidemic Kaposi’s sarcoma. J Biol Response Mod 4: 358–364

    PubMed  CAS  Google Scholar 

  117. Seifert A, Stellbrink HJ, Albrecht H, Gross G (1991) Eruptive HIV-associated Kaposi’s sarcoma following visceral leishmaniasis treated with interferon-gamma. Int Conf AIDS Jun 16–21, 1991; 7(1): 240 (abstract no. M.B.2234)

    Google Scholar 

  118. Mitsuyasu RT (1991) Use of recombinant interferons and hematopoietic growth factors in patients infected with human immunodeficiency virus. Rev Infect Dis 13: 971–972

    Article  Google Scholar 

  119. Albrecht H, Stellbrink HJ, Gross G, Berg B, Helmchen U, Mensing H (1994) Treatment of atypical leishmaniasis with interferon gamma resulting in progression of Kaposi’s sarcoma in an AIDS patient. Clin Investig 72: 1041–1047

    Article  PubMed  CAS  Google Scholar 

  120. Srolovitz H, Gornitsky M, Miller BA (1992) Regression of Kaposi’s sarcoma following intralesional interferon injections: histopathologic and immunocytochemical study. Int Conf AIDS, Jul 19–24, 1992; 8 (3): 136 (abstract no. PuB 7526)

    Google Scholar 

  121. Dupuy J, Price M, Lynch G, Bruce S, Schwartz M (1993) Intralesional interferon-alpha and zidovudine in epidemic Kaposi’s sarcoma. J Am Acad Dermatol 28: 966–972

    Article  PubMed  CAS  Google Scholar 

  122. Lanjewar DN, Shetty CR, Shroff HJ, Hira SK (1994) Response to sublingual alfa interferon in Kaposi’s sarcoma. Int Conf AIDS, Aug 7–12, 1994; 10 (1): 174 (abstract no. PB0124)

    Google Scholar 

Download references

Authors
  1. H. Jablonowski
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany

    Carlo Aul  & Wolfgang Schneider  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Jablonowski, H. (1997). Interferons in Kaposi’s Sarcoma. In: Aul, C., Schneider, W. (eds) Interferons. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60411-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60411-9_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61051-9

  • Online ISBN: 978-3-642-60411-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation