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Repair of Directly and Indirectly UV-Induced DNA Lesions and of DNA Double-Strand Breaks in Cells from Skin Cancer-Prone Patients with the Disorders Dysplastic Nevus Syndrome or Basal Cell Nevus Syndrome

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Risk and Progression Factors in Carcinogenesis

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 143))

Abstract

Hereditary disorders carrying an increased skin cancer risk, such as xeroderma pigmentosum (XP), dysplastic nevus syndrome (DNS), or basal cell nevus syndrome (BCNS), are valuable model systems that might provide insights into general mechanisms of skin carcinogenesis. This is especially true of XP, in which a defective repair of UV-induced DNA damage explains the increased risk of basal cell carcinomas, squamous cell carcinomas, and malignant melanomas in UV-exposed skin of affected patients (Kraemer et al. 1987; Barnes et al. 1993; Hoijmakers 1993).

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Author information

Authors and Affiliations

  1. Department of Dermatology, University of Würzburg, Josef-Schneider-Strasse 2, 97080, Würzburg, Germany

    T. M. Rünger, K. Möller, B. Dekant & D. Hellfritsch

  2. Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97080, Würzburg, Germany

    B. Epe

  3. Department of Dermatology, University of Göttingen, von-Siebold Strasse 3, 37075, Göttingen, Germany

    T. M. Rünger

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  1. T. M. Rünger
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  2. B. Epe
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Editors and Affiliations

  1. Pathologisches Institut, der Universität Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany

    H. K. Müller-Hermelink

  2. Institut für Pharmakologie und Toxikologie, der Universität Würzburg, Versbacher Straße 9, 97078, Würzburg, Germany

    H.-G. Neumann  & W. Dekant  & 

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Rünger, T.M., Epe, B., Möller, K., Dekant, B., Hellfritsch, D. (1997). Repair of Directly and Indirectly UV-Induced DNA Lesions and of DNA Double-Strand Breaks in Cells from Skin Cancer-Prone Patients with the Disorders Dysplastic Nevus Syndrome or Basal Cell Nevus Syndrome. In: Müller-Hermelink, H.K., Neumann, HG., Dekant, W. (eds) Risk and Progression Factors in Carcinogenesis. Recent Results in Cancer Research, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60393-8_24

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  • DOI: https://doi.org/10.1007/978-3-642-60393-8_24

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