Abstract
All organisms have evolved intricate networks of complementary DNA repair systems, enabling them to counteract a large variety of DNA damages. Among these, the cyclobutane pyrimidine dimers (CPDs) and the 6,4-pyrimidine-pyrimidone photoproducts (64PP) are certainly the most relevant since they are produced in massive amounts in human skin exposed to the shortwave component of natural sunlight. Genetic defects in DNA repair pathways or in damage-induced cell-cycle arrest result in chromosomal abnormalities, elevated levels of mutations, and a predisposition to cancer.
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© 1997 Springer-Verlag Berlin · Heidelberg
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Jaspers, N.G.J. (1997). DNA Repair: Genes, Enzymes, Patients, and Mouse Models. In: Müller-Hermelink, H.K., Neumann, HG., Dekant, W. (eds) Risk and Progression Factors in Carcinogenesis. Recent Results in Cancer Research, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60393-8_23
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DOI: https://doi.org/10.1007/978-3-642-60393-8_23
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