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Risk and Progression Factors in Carcinogenesis pp 321–327Cite as

Topoisomerase Activities in Undifferentiated Acute Myeloblastic Leukemias and Monocytic Differentiated Leukemias

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 143))

Abstract

The function of topoisomerases (topos) has been associated with proliferation and regulation of gene transcription during the differentiation of hematopoietic cells. The three different isoenzymes, topo I, topo II-alpha and topo II-beta, undergo additional posttranscriptional modifications (De Vore et al. 1992). These isoenzymes have various intracellular localizations and probably fulfill different functions (Boege et al. 1993; Zini et al. 1994), although there are hints that a functional loss of one isoenzyme can be partially substituted by another (Stevnser and Bohr 1993). Due to the posttranscriptional modifications, there is no direct correlation with gene transcription, protein content, or activity of topos, and several isoactivities can be found in nuclear extracts (Gieseler et al. 1993).

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Author information

Authors and Affiliations

  1. Medizinische Poliklinik, University of Würzburg, Klinikstr. 8, 97070, Würzburg, Germany

    F. Gieseler, C. Zernak, S. Valsamas, J. Kunze & M. Clark

  2. Medizinische Klinik und Poliklinik, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany

    A. Glasmacher

  3. Hospital Kröllwitz, University of Halle, Ernst-Grüber-Str. 40, 06120, Halle, Germany

    D. Kämpfe

Authors
  1. F. Gieseler
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  2. A. Glasmacher
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  3. D. Kämpfe
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  4. C. Zernak
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  5. S. Valsamas
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  6. J. Kunze
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  7. M. Clark
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Editor information

Editors and Affiliations

  1. Pathologisches Institut, der Universität Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany

    H. K. Müller-Hermelink

  2. Institut für Pharmakologie und Toxikologie, der Universität Würzburg, Versbacher Straße 9, 97078, Würzburg, Germany

    H.-G. Neumann  & W. Dekant  & 

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© 1997 Springer-Verlag Berlin · Heidelberg

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Gieseler, F. et al. (1997). Topoisomerase Activities in Undifferentiated Acute Myeloblastic Leukemias and Monocytic Differentiated Leukemias. In: Müller-Hermelink, H.K., Neumann, HG., Dekant, W. (eds) Risk and Progression Factors in Carcinogenesis. Recent Results in Cancer Research, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60393-8_22

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  • DOI: https://doi.org/10.1007/978-3-642-60393-8_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64385-9

  • Online ISBN: 978-3-642-60393-8

  • eBook Packages: Springer Book Archive

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