Abstract
Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin’s lymphoma derived from CD5-positive immature virgin B cells of the follicular mantle zone accounting for 5%–10% of malignant B-cell lymphomas in adults.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Banks PM, Chan J, Cleary ML, Delsol G, de Wolf-Peeters C, Gatter K, Grogan TM, Harris NL, Isaacson PG, Jaffe ES, Mason D, Pileri S, Ralfkiaer E, Stein H, Warnke RA (1992) Mantle cell lymphoma: a proposal for unification of morphologic, immunologic, and molecular data. Am J Surg Pathol 16: 637–640
Brittinger G (1983) Klinik der malignen Non-Hodgkin-Lymphome, speziell der chronischen lymphatischen Leukämie. Verh Dtsch Ges Pathol 67: 494–516
de Boer CJ, Loyson S, Kluin PM, Kluin-Nelemans C, Schuring E, van Krieken HJM
Multiple breakpoints within the Bcl-1 locus in B-cell lymphoma: rearrangements of the cyclin Dl gene. Cancer Res 53: 4148–4152
Fisher RI, Dahlberg S, Nathwani BN, Banks PM, Miller TP, Grogan TM (1995) A clinical analysis of two indolent lymphoma entities: mantle cell lymphoma and marginal zone lymphoma (including the mucosa-associated lymphoid tissue and monocytoid B-cell subcategories): a Southwest Oncology Group study. Blood 85: 1075–1082
Harris NL, Jaffe ES, Stein H et al (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study group. Blood 84: 1361–1392
Lardelli P, Bookman MA, Sundeen J, Longo DL, Jaffe ES (1990) Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunologic spectrum and clinical correlations. Am J Surg Pathol 14: 752–763
Lennert K (1978) Lymphomas of germinal-center cells. In: Lennert K (ed) Malignant lymphomas other than Hodgkin’s disease. Springer, Berlin Heidelberg New York, pp 281–345
Lo Coco F, Gaidano G, Loui DC, Offit K, Chaganti RSK, Dalla-Favera R (1993) p53 Mutations are associated with histologic transformation of follicular lymphoma. Blood 82: 2289–2295
Lukas J, Pagano M, Staskova Z, Draetta G, Bartek J (1994) Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines. Oncogene 9: 707–718
Matsushime H, Roussel MF, Ashmun RA, Sherr CJ (1991) Colony-stimulating factor 1 regulates novel cyclins during the Gl phase of the cell cycle. Cell 65: 701–713
Ott MM, Ott G, Kuse R, Porowski P, Gunzer U, Feller AC, Müller-Hermelink HK (1994) The anaplastic variant of centrocytic lymphoma is marked by frequent rearrangements of the bcl-1 gene and high proliferation indices. Histopathology 24: 329–334
Ott MM, Helbing A, Ott G, Bartek J, Fischer L, Dürr A, Kreipe H, Müller-Hermelink HK (1996a) Bcl-1 gene rearrangement and cyclin D1 protein expression in mantle cell lymphoma (in press)
Ott G, Kalla J, Ott MM, Schryen B, Katzenberger T, Müller JG, Müller-Hermelink HK (1996b) Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the MTC locus and tetraploid chromosome clones (submitted for publication) Rimokh R, Berger F, Delsol G, Digonnet I, Rouault, Tigaud JD, Gadoux M, Coiffier B, Bryon PA, Magaud JP (1994) Detection of the chromosomal translocation t(l 1; 14) by polymerase chain reaction in mantle cell lymphomas. Blood 83: 1871–1875
Sander CA, Yano T, Clark HM, Harris C, Longo DL, Jaffe ES, Raffeld M (1993) p53 Mutation is associated with progression of follicular lymphomas. Blood 82: 1994–2004
Schlegelberger B, Himmler A, Godde E, Grote W, Feller AC, Lennert K (1994) Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low- grade and high-grade lymphomas. Blood 83: 505–511
Stein H, Lennert K, Feller AC, Mason DY (1984) Immunohistochemical analysis of human lymphoma: correlation of histological and immunological categories. Adv Cancer Res 42: 67–147
Tilly H, Rossi A, Stamatoullas A, Lenormand B, Bigorgne C, Kunlin A, Monconduit M, Bastard C (1994) Prognostic value of chromosomal abnormalities in follicular lymphoma. Blood 84: 1043–1049
Tolksdorf G, Stein H, Lennert K (1980) Morphological and immunological definition of a malignant lymphoma derived from germinal-center cells with cleaved nuclei (centrocytes). Br J Cancer 41: 168–182
Tsujimoto Y, Yunis J, Onorato-Showe L, Erikson J, No well PC, Croce CM (1984) Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leuke- mias with the t(ll;14) chromosome translocation. Science 224: 1403–1406
Weisenburger DD, Kim H, Rapaport H (1982) Mantle zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma. Cancer 49: 1429–1438
Weisenburger DD, Sanger WG, Armitage JO, Purtilo DT (1987) Intermediate lymphocytic lymphoma: immunophenotypic and cytogenetic findings. Blood 69: 1617–1621
Williams ME, Westermann CD, Swerdlow SH (1990) Genotypic characterization of centrocytic lymphoma: frequent rearrangement of the chromosome 11 bcl-1 locus. Blood 76: 1387–1391
Williams ME, Meeker TC, Swerdlow SH (1991) Rearrangement of the chromosome 11 bcl-1 locus in centrocytic lymphoma: analysis with multiple breakpoint probes. Blood 76: 1387–1391
Williams ME, Swerdlow SH, Rosenberg CL, Arnold A (1992) Characterization of chromosome 11 translocation breakpoints at the bcl-1 and PRAD1 loci in centrocytic lymphoma. Cancer Res 52 [Suppl]: 5541s–5544s
Williams ME, Swerdlow SH, Meeker TC (1993) Chromosome t(ll;14) (ql3;q32) breakpoints in centrocytic lymphoma are highly localized at the bcl-1 major trans-location cluster. Leukemia 7: 1437–1440
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Ott, G. et al. (1997). Genetic Lesions in Mantle Cell Lymphoma. In: Müller-Hermelink, H.K., Neumann, HG., Dekant, W. (eds) Risk and Progression Factors in Carcinogenesis. Recent Results in Cancer Research, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60393-8_21
Download citation
DOI: https://doi.org/10.1007/978-3-642-60393-8_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64385-9
Online ISBN: 978-3-642-60393-8
eBook Packages: Springer Book Archive