Skip to main content

Genetic Lesions in Mantle Cell Lymphoma

  • Conference paper
Risk and Progression Factors in Carcinogenesis

Abstract

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin’s lymphoma derived from CD5-positive immature virgin B cells of the follicular mantle zone accounting for 5%–10% of malignant B-cell lymphomas in adults.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Banks PM, Chan J, Cleary ML, Delsol G, de Wolf-Peeters C, Gatter K, Grogan TM, Harris NL, Isaacson PG, Jaffe ES, Mason D, Pileri S, Ralfkiaer E, Stein H, Warnke RA (1992) Mantle cell lymphoma: a proposal for unification of morphologic, immunologic, and molecular data. Am J Surg Pathol 16: 637–640

    CAS  Google Scholar 

  • Brittinger G (1983) Klinik der malignen Non-Hodgkin-Lymphome, speziell der chronischen lymphatischen Leukämie. Verh Dtsch Ges Pathol 67: 494–516

    PubMed  CAS  Google Scholar 

  • de Boer CJ, Loyson S, Kluin PM, Kluin-Nelemans C, Schuring E, van Krieken HJM

    Google Scholar 

  • Multiple breakpoints within the Bcl-1 locus in B-cell lymphoma: rearrangements of the cyclin Dl gene. Cancer Res 53: 4148–4152

    Google Scholar 

  • Fisher RI, Dahlberg S, Nathwani BN, Banks PM, Miller TP, Grogan TM (1995) A clinical analysis of two indolent lymphoma entities: mantle cell lymphoma and marginal zone lymphoma (including the mucosa-associated lymphoid tissue and monocytoid B-cell subcategories): a Southwest Oncology Group study. Blood 85: 1075–1082

    PubMed  CAS  Google Scholar 

  • Harris NL, Jaffe ES, Stein H et al (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study group. Blood 84: 1361–1392

    PubMed  CAS  Google Scholar 

  • Lardelli P, Bookman MA, Sundeen J, Longo DL, Jaffe ES (1990) Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunologic spectrum and clinical correlations. Am J Surg Pathol 14: 752–763

    Article  PubMed  CAS  Google Scholar 

  • Lennert K (1978) Lymphomas of germinal-center cells. In: Lennert K (ed) Malignant lymphomas other than Hodgkin’s disease. Springer, Berlin Heidelberg New York, pp 281–345

    Google Scholar 

  • Lo Coco F, Gaidano G, Loui DC, Offit K, Chaganti RSK, Dalla-Favera R (1993) p53 Mutations are associated with histologic transformation of follicular lymphoma. Blood 82: 2289–2295

    Google Scholar 

  • Lukas J, Pagano M, Staskova Z, Draetta G, Bartek J (1994) Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines. Oncogene 9: 707–718

    PubMed  CAS  Google Scholar 

  • Matsushime H, Roussel MF, Ashmun RA, Sherr CJ (1991) Colony-stimulating factor 1 regulates novel cyclins during the Gl phase of the cell cycle. Cell 65: 701–713

    Article  PubMed  CAS  Google Scholar 

  • Ott MM, Ott G, Kuse R, Porowski P, Gunzer U, Feller AC, Müller-Hermelink HK (1994) The anaplastic variant of centrocytic lymphoma is marked by frequent rearrangements of the bcl-1 gene and high proliferation indices. Histopathology 24: 329–334

    Article  PubMed  CAS  Google Scholar 

  • Ott MM, Helbing A, Ott G, Bartek J, Fischer L, Dürr A, Kreipe H, Müller-Hermelink HK (1996a) Bcl-1 gene rearrangement and cyclin D1 protein expression in mantle cell lymphoma (in press)

    Google Scholar 

  • Ott G, Kalla J, Ott MM, Schryen B, Katzenberger T, Müller JG, Müller-Hermelink HK (1996b) Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the MTC locus and tetraploid chromosome clones (submitted for publication) Rimokh R, Berger F, Delsol G, Digonnet I, Rouault, Tigaud JD, Gadoux M, Coiffier B, Bryon PA, Magaud JP (1994) Detection of the chromosomal translocation t(l 1; 14) by polymerase chain reaction in mantle cell lymphomas. Blood 83: 1871–1875

    Google Scholar 

  • Sander CA, Yano T, Clark HM, Harris C, Longo DL, Jaffe ES, Raffeld M (1993) p53 Mutation is associated with progression of follicular lymphomas. Blood 82: 1994–2004

    Google Scholar 

  • Schlegelberger B, Himmler A, Godde E, Grote W, Feller AC, Lennert K (1994) Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low- grade and high-grade lymphomas. Blood 83: 505–511

    PubMed  CAS  Google Scholar 

  • Stein H, Lennert K, Feller AC, Mason DY (1984) Immunohistochemical analysis of human lymphoma: correlation of histological and immunological categories. Adv Cancer Res 42: 67–147

    Article  PubMed  CAS  Google Scholar 

  • Tilly H, Rossi A, Stamatoullas A, Lenormand B, Bigorgne C, Kunlin A, Monconduit M, Bastard C (1994) Prognostic value of chromosomal abnormalities in follicular lymphoma. Blood 84: 1043–1049

    PubMed  CAS  Google Scholar 

  • Tolksdorf G, Stein H, Lennert K (1980) Morphological and immunological definition of a malignant lymphoma derived from germinal-center cells with cleaved nuclei (centrocytes). Br J Cancer 41: 168–182

    Article  PubMed  CAS  Google Scholar 

  • Tsujimoto Y, Yunis J, Onorato-Showe L, Erikson J, No well PC, Croce CM (1984) Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leuke- mias with the t(ll;14) chromosome translocation. Science 224: 1403–1406

    Article  PubMed  CAS  Google Scholar 

  • Weisenburger DD, Kim H, Rapaport H (1982) Mantle zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma. Cancer 49: 1429–1438

    Article  PubMed  CAS  Google Scholar 

  • Weisenburger DD, Sanger WG, Armitage JO, Purtilo DT (1987) Intermediate lymphocytic lymphoma: immunophenotypic and cytogenetic findings. Blood 69: 1617–1621

    Google Scholar 

  • Williams ME, Westermann CD, Swerdlow SH (1990) Genotypic characterization of centrocytic lymphoma: frequent rearrangement of the chromosome 11 bcl-1 locus. Blood 76: 1387–1391

    PubMed  CAS  Google Scholar 

  • Williams ME, Meeker TC, Swerdlow SH (1991) Rearrangement of the chromosome 11 bcl-1 locus in centrocytic lymphoma: analysis with multiple breakpoint probes. Blood 76: 1387–1391

    Google Scholar 

  • Williams ME, Swerdlow SH, Rosenberg CL, Arnold A (1992) Characterization of chromosome 11 translocation breakpoints at the bcl-1 and PRAD1 loci in centrocytic lymphoma. Cancer Res 52 [Suppl]: 5541s–5544s

    PubMed  CAS  Google Scholar 

  • Williams ME, Swerdlow SH, Meeker TC (1993) Chromosome t(ll;14) (ql3;q32) breakpoints in centrocytic lymphoma are highly localized at the bcl-1 major trans-location cluster. Leukemia 7: 1437–1440

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Ott, G. et al. (1997). Genetic Lesions in Mantle Cell Lymphoma. In: Müller-Hermelink, H.K., Neumann, HG., Dekant, W. (eds) Risk and Progression Factors in Carcinogenesis. Recent Results in Cancer Research, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60393-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60393-8_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64385-9

  • Online ISBN: 978-3-642-60393-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics