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Growth and Transformation of Human Oral Epithelium In Vitro

  • Conference paper
Risk and Progression Factors in Carcinogenesis

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 143))

Abstract

Cancer of the head and neck poses a major health problem in the world. In 19S5, the number of new malignant neoplasms of the mouth and pharynx (International Classification of Disease, ninth revision, ICD-9 140–149) was estimated to be 500 000; this is therefore the sixth most common anatomical site (Parkin and Muir 1992). Roughly half of these cases occur in southern Asia and China. In parts of India where the use of chews containing betel and tobacco is frequent, these tumors are the most common form of cancer (Parkin et al. 1993). Trends for the most common tumor type, head and neck squamous cell carcinoma (HNSCC), vary by anatomical subsite and geographical region. For tumors of the tongue, mouth, and pharynx, rates are rising in many areas of the world. In most European countries, the mortality rates for the disease have increased substantially since the mid-1970s, especially at younger ages (La Vecchia et al. 1992; Franceschi et al. 1994; Boyle et al. 1995). Early symptoms of disease, often vague, are easily overlooked. The majority of patients are diagnosed with advanced cancer (stage III or IV), a negative determinant in the outcome of treatment (Vokes et al. 1993). Accordingly, long-term survival has not improved significantly in recent decades.

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  1. Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177, Stockholm, Sweden

    R. C. Grafström, U. G. Norén, X. Zheng, Å. Elfwing & K. Sundqvist

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  1. R. C. Grafström
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  2. U. G. Norén
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  3. X. Zheng
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  4. Å. Elfwing
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  1. Pathologisches Institut, der Universität Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany

    H. K. Müller-Hermelink

  2. Institut für Pharmakologie und Toxikologie, der Universität Würzburg, Versbacher Straße 9, 97078, Würzburg, Germany

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Grafström, R.C., Norén, U.G., Zheng, X., Elfwing, Å., Sundqvist, K. (1997). Growth and Transformation of Human Oral Epithelium In Vitro. In: Müller-Hermelink, H.K., Neumann, HG., Dekant, W. (eds) Risk and Progression Factors in Carcinogenesis. Recent Results in Cancer Research, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60393-8_20

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