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The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth

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Risk and Progression Factors in Carcinogenesis

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 143))

Abstract

Cells are continually experiencing various forms of DNA damage. External factors such as environmental agents and radiation or internal factors such as oxidative damage or replication errors can all lead to potentially mutagenic or lethal DNA lesions. UV irradiation and DNA strand interruptions, for example, stimulate transcription and genetic recombination, lead to the activation of DNA repair proteins, cause cell cycle arrest, and initiate nuclear signal transduction cascades (Hartwell 1992; Hartwell and Weinart 1989; Hibi et al. 1993).

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Author information

Authors and Affiliations

  1. ICOS Corporation, 22021-20th Ave S.E., Bothell, WA, 98021, USA

    E. Christenson, A. J. DeMaggio & M. F. Hoekstra

Authors
  1. E. Christenson
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  2. A. J. DeMaggio
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  3. M. F. Hoekstra
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Editor information

Editors and Affiliations

  1. Pathologisches Institut, der Universität Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany

    H. K. Müller-Hermelink

  2. Institut für Pharmakologie und Toxikologie, der Universität Würzburg, Versbacher Straße 9, 97078, Würzburg, Germany

    H.-G. Neumann  & W. Dekant  & 

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© 1997 Springer-Verlag Berlin · Heidelberg

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Christenson, E., DeMaggio, A.J., Hoekstra, M.F. (1997). The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth. In: Müller-Hermelink, H.K., Neumann, HG., Dekant, W. (eds) Risk and Progression Factors in Carcinogenesis. Recent Results in Cancer Research, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60393-8_19

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  • DOI: https://doi.org/10.1007/978-3-642-60393-8_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64385-9

  • Online ISBN: 978-3-642-60393-8

  • eBook Packages: Springer Book Archive

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