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Analysis of Genetic Factors and Molecular Mechanisms in the Development of Hereditary and Carcinogen-Induced Tumors of Xiphophorus

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Risk and Progression Factors in Carcinogenesis

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 143))

Abstract

The number and amount of carcinogenic agents in our environment has raised steadily increasing public concern and led to a decline in interest in another aspect of turmorigenesis, namely the involvement of genetic factors in the processes that lead to malignant tumors. It is becoming evident that both the noxious influences in the environment and the genetic makeup of cells or of the whole individual are involved in cancerous processes to a similar extent. Animal models offer unique possibilities to analyze the extreme complexity of the interaction of multiple genetic factors and various molecular mechanisms underlying tumor formation. A well-accepted system for tumor development is the Xiphophorus melanoma model.

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References

  • Adam D, Mäueler W, Schartl M (1991) Transcriptional activation of the melanoma inducing Xmrk oncogene in Xiphophorus. Oncogene 6: 73–80

    PubMed  CAS  Google Scholar 

  • Adam D, Dimitrijevic N, Schartl M (1993) Tumor suppression in Xiphophorus by an accidentally acquired promoter. Science 259: 816–819

    Article  PubMed  CAS  Google Scholar 

  • Ahuja MR, Anders F (1976) A genetic concept of the origin of cancer, based in part upon studies of neoplasms in fishes. Prog Exp Tumor Res 20: 380–397

    PubMed  CAS  Google Scholar 

  • Anders F (1990) A biologist’s view of human cancer. In: Neth R, Frolova E, Gallo RC, Greaves MF, Afanasiev BV, Elstner E (eds) Modern trends in human leukemia, vol 8. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Anders F, Schartl M, Barnekow A, Anders A (1984) Xiphophorus as an in vivo model for studies on normal and defective control of oncogenes. Adv Cancer Res 42: 191–275

    Article  PubMed  CAS  Google Scholar 

  • De Flora S, Vigano L, D’Agostini F, Camoirano A, Bagnasco M, Bennicelli C, Melodia F, Arillo A (1993) Multiple genotoxicity biomarkers in fish exposed in situ to polluted river water. Mutat Res 319 (3): 167–177

    Article  PubMed  Google Scholar 

  • Gordon M (1927) The genetics of viviparous top-minnow Platypoecilus: the inheritance of two kinds of melanophores. Genetics 12: 253–283

    PubMed  CAS  Google Scholar 

  • Hannig G, Ottilie S, Schartl M (1991) Conservation of structure and expression of the c-yes andfyn genes in lower vertebrates. Oncogene 6: 361–369

    PubMed  CAS  Google Scholar 

  • Häussler G (1928) Über Melanombildungen bei Bastarden vonXiphophorus maculatus var. rubra. Klin Wochenschr 7: 1561–1562

    Article  Google Scholar 

  • Hyodo-Taguchi Y, Matsudaira H (1987) Higher susceptibility to N-methyl-N’-nitro-N- nitrosoguanidine-induced tumorigenesis in an interstrain hybrid of the fish,Oryzias latipes (medaka). Jpn J Cancer Res (Gann) 78: 487–493

    CAS  Google Scholar 

  • Kosswig C (1928) Über Kreuzungen zwischen den TeleostiernXiphophorus helleri undPlatypoecilus maculatus. Z Indukt Abstammungs Vererbungsl 47: 150–158

    Article  Google Scholar 

  • Mäueler W, Raulf F, Schartl M (1988) Expression of proto-oncogenes in embryonic, adult, and transformed tissue of Xiphophorus ( Teleostei: Poeciliidae). Oncogene 2: 421–430

    PubMed  Google Scholar 

  • Mäueler W, Schartl A, Schartl M (1993) Different expression patterns of oncogenes and proto-oncogenes in hereditary and carcinogen-induced tumors of Xiphophorus. Int J Cancer 55: 288–296

    Article  PubMed  Google Scholar 

  • Malitschek B, Wittbrodt J, Fischer P, Lammers R, Ullrich A, Schartl M (1994) Autocrine stimulation of theXmrk receptor tyrosine kinase in Xiphophorus melanoma cells and identification of a source for the physiological ligand. J Biol Chem 269: 10423–10430

    PubMed  CAS  Google Scholar 

  • Schartl M (1988) A sex chromosomal restriction-fragment-length marker linked to melanoma-determining Tu loci in Xiphophorus. Genetics 119: 679–685

    PubMed  CAS  Google Scholar 

  • Schartl M, Peter RU (1988) Progressive growth of fish tumors after transplantation into thymus-aplastic(nu/nu) mice. Cancer Res 48: 741–744

    PubMed  CAS  Google Scholar 

  • Schartl A, Malitschek B, Kazianis S, Borowsky R, Schartl M (1995) Spontaneous melanoma formation in non-hybrid Xiphophorus. Cancer Res 55: 159–165

    PubMed  CAS  Google Scholar 

  • Stopper H, Kühnel A, Podschun B (1994) Combination of the chemotherapeutic agent 5-fluoro-uracil with an inhibitor of its catabolism results in increased micronucleus induction. Biochem Biophys Res Commun 203: 1124–1130

    Article  PubMed  CAS  Google Scholar 

  • Wellbrock C, Lammers R, Ullrich A, Schartl M (1995) Association between the melanoma-inducing receptor tyrosine kinase Xmrk and src family tyrosine kinases in Xiphophorus. Oncogene 10: 2135–2143

    PubMed  CAS  Google Scholar 

  • Winkler C, Wittbrodt J, Lammers R, Ullrich A, Schartl M (1994) Ligand-dependent tumor induction in medakafish embryos by aXmrk receptor tyrosine kinase trans-gene. Oncogene 9: 1517–1525

    PubMed  CAS  Google Scholar 

  • Wittbrodt J, Adam D, Malitschek B, Mäueler W, Raulf F, Telling A et al (1989) Novel putative receptor tyrosine kinase encoded by the melanoma-inducingTu locus in Xiphophorus. Nature 341: 415–421

    Article  PubMed  CAS  Google Scholar 

  • Wittbrodt J, Lammers R, Malitschek B, Ullrich A, Schartl M (1992) TheXmrk receptor tyrosine kinase is activated in Xiphophorus malignant melanoma. EMBO J 11: 4239–4246

    PubMed  CAS  Google Scholar 

  • Zechel C, Schleenbecker U, Anders A, Anders F (1988) v-erb B related sequences in Xiphophorus that map to melanoma determining Mendelian loci and overexpress in a melanoma cell line. Oncogene 3: 605–617

    PubMed  CAS  Google Scholar 

  • Zechel C, Schleenbecker U, Anders A, Pfütz M, Anders F (1989) Search for genes critical for the early and/or late events in carcinogenesis: studies in Xiphophorus (Pisces, Teleostei). In: Neth R, Frolova E, Gallo RC, Greaves MF, Afanasiev BV, Elstner E (eds) Modern trends in human leukemia, vol 8. Springer, Berlin Heidelberg New York, pp 366–385

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Physiological Chemistry I, Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074, Würzburg, Germany

    A. Schartl, M. Pagany, M. Engler & M. Schartl

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  1. A. Schartl
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  2. M. Pagany
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  3. M. Engler
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  4. M. Schartl
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Editor information

Editors and Affiliations

  1. Pathologisches Institut, der Universität Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany

    H. K. Müller-Hermelink

  2. Institut für Pharmakologie und Toxikologie, der Universität Würzburg, Versbacher Straße 9, 97078, Würzburg, Germany

    H.-G. Neumann  & W. Dekant  & 

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© 1997 Springer-Verlag Berlin · Heidelberg

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Schartl, A., Pagany, M., Engler, M., Schartl, M. (1997). Analysis of Genetic Factors and Molecular Mechanisms in the Development of Hereditary and Carcinogen-Induced Tumors of Xiphophorus. In: Müller-Hermelink, H.K., Neumann, HG., Dekant, W. (eds) Risk and Progression Factors in Carcinogenesis. Recent Results in Cancer Research, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60393-8_15

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  • DOI: https://doi.org/10.1007/978-3-642-60393-8_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64385-9

  • Online ISBN: 978-3-642-60393-8

  • eBook Packages: Springer Book Archive

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