Abstract
Regulatory agencies have the responsibility for assessing the potential risks that chemicals pose to humans. For risk assessment, these agencies evaluate data from in vitro genotoxicity assays (e.g., mutation induction using cells in culture) and from in vivo assays (e.g., micronucleus induction in bone marrow or carcinogenicity testing in rodents). The goal is to develop sensitive models that predict carcinogenic potential in susceptible human populations. Until recently, it was impossible to evaluate whether the genetic events induced by test compounds in the model systems were the same as the genetic events contributing to human cancers. However, new techniques make it possible to evaluate these events in both human and model systems and should aid in evaluating the appropriateness of any particular assay in predicting the disease in humans.
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Caspary, W.J., Stopper, H., Hozier, J.C., Liechty, M.C., Davis, L.M. (1997). Mechanisms Leading to the Expression of Recessive Alleles: The Use of Polymorphic Microsatellites and Whole-Chromosome Painting Probes to Analyze Mouse Tumors, Mutants, and Micronuclei. In: Müller-Hermelink, H.K., Neumann, HG., Dekant, W. (eds) Risk and Progression Factors in Carcinogenesis. Recent Results in Cancer Research, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60393-8_11
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