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Alkalischer Reflux

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Gastrointestinale Funktionsstörungen

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Zusammenfassung

Die gastroösophageale Refluxkrankheit ist die häufigste gutartige Erkrankung der Speiseröhre und betrifft ungefähr 10–30% der westlichen Bevölkerung [15]. Verantwortlich für diese Erkrankung ist symptomatischer oder asymptomatischer Reflux von Magen-oder Duodenalsaft in die Speiseröhre mit oder ohne Veränderungen an der Speiseröhrenschleimhaut. Salzsäure und Pepsin sind die am besten untersuchten Inhaltsstoffe aus dem Magen, die zur Entwicklung von Symptomen in der Speiseröhre und zu Veränderungen an der Mukosa führen können. Darüber hinaus kann sich Magensaft mit Flüssigkeit aus dem Duodenum durch transpylorischen Reflux von Gallensäuren oder Pankreasenzymen vermischen [14, 40]. Dieser duodenogastrische Reflux tritt auch bei Normalpersonen auf, hier jedoch überwiegend nachts und postprandial [17, 18, 44]. Für die Epithelschäden verantwortlich gemacht werden v.a. Gallensäuren, aber auch Trypsin und Lezithin [21, 28].

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Authors
  1. W. K. H. Kauer
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  2. H. J. Stein
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Editors and Affiliations

  1. Chirurgische Universitätsklinik, Josef-Schneider-Str. 2, 97080, Würzburg, Deutschland

    K.-H. Fuchs  & A. Thiede  & 

  2. Chirurgische Klinik, Ismaninger Str. 22, 81675, München, Deutschland

    H. J. Stein

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© 1997 Springer-Verlag Berlin Heidelberg

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Kauer, W.K.H., Stein, H.J. (1997). Alkalischer Reflux. In: Fuchs, KH., Stein, H.J., Thiede, A. (eds) Gastrointestinale Funktionsstörungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60372-3_38

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  • DOI: https://doi.org/10.1007/978-3-642-60372-3_38

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  • Print ISBN: 978-3-642-64375-0

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