Skip to main content
SpringerLink
Log in
Book cover

Adverse Effects of Herbal Drugs pp 137–144Cite as

Teucrium Chamaedrys

  • Chapter

Part of the book series: Adverse Effects of Herbal Drugs ((HERBAL DRUGS,volume 3))

Abstract

Teucrium chamaedrys L. (= Teucrium officinale Lam. = Chamaedrys officinalis Moench.) belongs to the Lamiaceae. Vernacular names are common germander, wall germander (E); Gamander, Edelgamander (D); germandrée petit-chêne, germandrée chamaedrys (F) [1–3]. The plant part which is used medicinally is the flowering herb [3,4].

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hoppe HA (1975) Drogenkunde. Band 1. Angiospermen. 8. Auflage. Berlin: Walter de Gruyter, pp.1066–1067

    Google Scholar 

  2. List PH, Hörhammer L (1979) Hagers Handbuch der Pharmazeutischen Praxis. Vierte Neuausgabe. Sechster Band. Chemikalien und Drogen, Teil C: T-Z. Berlin: Springer-Verlag

    Google Scholar 

  3. Launert E (1981) Hamlyn guide to edible and medicinal plants of Britain and Northern Europe. London: Hamlyn, p.170

    Google Scholar 

  4. Anonymous (1986) Avis aux fabricants concernant les demandes d’autorisation de mise sur le marché de specialités pharmaceutiques à base de plantes. Fascicule spécial no.86/20 bis. Paris: Direction de la Pharmacie et du Médicament, Ministère des Affaires Sociales et de l’Emploi

    Google Scholar 

  5. Papanov GY, Malakov PY (1980) Furanoid diterpenes in the bitter fraction of Teucrium chamaedrys L. Z Naturforsch 35b: 764–766

    CAS  Google Scholar 

  6. Gács-Baitz E, Kajtár M, Papanov GY, Malakov PY (1982) Carbon-13 NMR spectra of some furanoid diterpenes from Teucrium species. Heterocycles (Sendai) 19:539–550

    Article  Google Scholar 

  7. Malakov PY, Papanov GY (1985) Teuchamaedrin C, a neo-clerodane diterpenoid from Teucrium chamaedrys. Phytochemistry 24:301–303

    Article  CAS  Google Scholar 

  8. Savona G, García-Alvarez MC, Rodríguez B (1982) Dihydroteugin, a neo-clerodane diterpenoid from Teucrium chamaedrys. Phytochemistry 21:721–723

    Article  CAS  Google Scholar 

  9. Eguren L, Perales A, Fayos J, Rodríguez B, Savona G, Piozzi F (1982) New neoclerodane diterpenoid containing an oxetane ring isolated from Teucrium chamaedrys. X-ray structure determination. J Org Chem 47:4157–4160

    Article  CAS  Google Scholar 

  10. Fernández-Gadea F, Pascual C, Rodréguez B, Savona G (1983) 6-Epiteucrin A, a neo-clerodane diterpenoid from Teucrium chamaedrys. Phytochemistry 22:723–725

    Article  Google Scholar 

  11. Garcia-Alvarez MC, Lukacs G, Neszmelyi A, Piozzi F, Rodríguez B, Savona G (1983) Structure of teucroxide. Application of natural-abundance 13C-13C coupling constants observed via double-quantum coherence. J Org Chem 48:5123–5126

    Article  CAS  Google Scholar 

  12. Rodríguez M-C, Barluenga J, Savona G, Piozzi F, Servettaz O, Rodriguez B (1984) Isoteuflidin, a neo-clerodane diterpenoid from Teucrium chamaedrys, and revised structures of teucrins F and G. Phytochemistry 23:1465–1469

    Article  Google Scholar 

  13. Rodríguez M-C, Barluenga J, Pascual C, Rodríguez B, Savona G, Piozzi F (1984) Neo-clerodane diterpenoids from Teucrium chamaedrys: the identity of teucrin B with dihydroteugin. Phytochemistry 23:2960–2961

    Article  Google Scholar 

  14. Grzybek J (1968) Phytochemical characteristics of the species of genus Teucrium L. germander indigenous in Poland. Part I. Free sugars and flavonoids. Dissertationes Pharmaceuticae et Pharmacologicae 20:563–572

    CAS  Google Scholar 

  15. Grzybek J (1969) Phytochemical characteristics of the native Teucrium L. species. Part II. The remaining identified Compounds. Dissertationes Pharmaceuticae et Pharmacologicae 21:253–260

    CAS  Google Scholar 

  16. Gross G-A, Lahloub MF, Anklin C, Schulten H-R, Sticher O (1988) Teucrioside, a phenyl-propanoid glycoside from Teucrium chamaedrys. Phytochemistry 27:1459–1463

    Article  CAS  Google Scholar 

  17. Harborne JB, Tomás-Barberán FA, Williams CA, Gil MI (1986) A chemotaxonomic study of flavonoids from European Teucrium species. Phytochemistry 25:2811–2816

    Article  CAS  Google Scholar 

  18. Chialva F, Gabri G, Liddle PAP, Ulian F (1982) Qualitative evaluation of aromatic herbs by direct headspace GC analysis. Applications of the method and comparison with the traditional analysis of essential oils. J High Resolut Chromatogr Chromatogr Commun 5:182–188

    Article  CAS  Google Scholar 

  19. Larrey D (1992) Hépatotoxicité: la phytothérapie aussi. Gastroenterol Clin Biol 16:913–915

    PubMed  CAS  Google Scholar 

  20. Castot A, Larrey D (1992) Hépatites observées au cours d’un traitement par un médicament ou une tisane contenant de la germandrée petit-chêne. Bilan des 26 cas rapportés aux Centres Régionaux de Pharmacovigilance. Gastroenterol Clin Biol 16:916–922

    PubMed  CAS  Google Scholar 

  21. Larrey D, Vial T, Pauwels A, Castot A, Biour M, David M, Michel H (1992) Hepatitis after germander (Teucrium chamaedrys) administration: another instance of herbal medicine hepatotoxicity. Ann Intern Med 117:129–132

    PubMed  CAS  Google Scholar 

  22. Anonymous (1990) Avis aux fabricants concernant les demandes d’autorisation de mise sur le marché des médicaments à base de plantes. Fascicule spécial no. 90/22 bis. Paris: Direction de la Pharmacie et du Médicament, Ministère des Affaires Sociales et de la Solidarité

    Google Scholar 

  23. Grzybek J (1971) Biological activity of the extracts from native species of Teucrium L. Dissertationes Pharmaceuticae et Pharmacologicae 23:163–171

    Google Scholar 

  24. Nagao Y, Ito N, Kohno T, Kuroda H, Fujita E (1982) Antitumor activity of Rabdosia and Teucrium diterpenoids against P388 lymphocytic leukemia in mice. Chem Pharm Bull (Tokyo) 30: 727–729

    CAS  Google Scholar 

  25. Node M, Sai M, Fujita E (1981) Isolation of the diterpenoid teuflin (6-epiteucvin) from Teucrium viscidum var. miquelianum. Phytochemistry 20:757–760

    Article  CAS  Google Scholar 

  26. Simmonds MSJ, Blaney WM, Ley SV, Savona G, Bruno M, Rodríguez B (1989) The antifeedant activity of clerodane diterpenoids from Teucrium. Phytochemistry 28:1069–1071

    Article  CAS  Google Scholar 

  27. Anonymous (1992) Dossier Technique destiné à la presse profesionnelle médicale et pharmaceutique. Objet: Médicaments à base de germandrée-petit-chêne. Paris: Ministère de la Santé et de l’Action Humanitaire

    Google Scholar 

  28. Pauwels A, Thierman-Duffaud D, Azanowsky JM, Loiseau D, Biour M, Levy VG (1992) Hépatite aigue à la germandrée petit-chêne. Hépatotoxicité d’une plante medicinale. Deux observations. Gastroenterol Clin Biol 16:92–95

    PubMed  CAS  Google Scholar 

  29. Mattei A, Bizollon T, Charles J-D, Debat P, Fontanges T, Chevallier M, Trepo C (1992) Atteinte hépatique associée à la prise d’un produit de Phytothérapie contenant de la germandrée petit-chêne. Quatre cas. Gastroenterol Clin Biol 16:798–800

    PubMed  CAS  Google Scholar 

  30. Legoux J-L, Maitre F, Labarrière D, Gargot D, Festin D, Causse X (1992) Hépatite cytolytique et germandrèe petit-chêne: un nouveau cas avec réintroduction. Gastroenterol Clin Biol 16:813–815

    PubMed  CAS  Google Scholar 

  31. Diaz D, Ferroudji S, Heran B, Barneon G, Larrey D, Michel H (1992) Hépatite fulminante à la germandrée petit-chêne. Gastroenterol Clin Biol 16:1006–1007

    PubMed  CAS  Google Scholar 

  32. Dao T, Peytier A, Galateau F, Valla A (1993) Hépatite chronique cirrhogène à la germandrée petit-chêne. Gastroenterol Clin Biol 17:609–610

    PubMed  CAS  Google Scholar 

  33. Mostefa-Kara N, Pauwels A, Pines E, Biour M, Levy VG (1992) Fatal hepatitis after herbal tea. Lancet 340:674

    Article  PubMed  CAS  Google Scholar 

  34. Ben Yahia M, Mavier P, Métreau J-M, Zafrani ÉS, Fabre M, Gatineau-Saillant G, Dhumeaux D, Mallat A (1993) Hépatite chronique active et cirrhose induites par la germandrée petit-chêne. Trois cas. Gastroenterol Clin Biol 17:959–962

    PubMed  CAS  Google Scholar 

  35. Loeper J, Descatoire V, Lettéron P, Moulis C, Degott C, Pessayre D (1993) Mechanism for the hepatotoxicity of germander (Teucrium chamaedrys), a plant responsible for an epidemic of hepatitis in France. J Hepatol (Amsterdam) 18 (Suppl.1):S74

    Google Scholar 

  36. Loeper J, Descatoire V, Letteron P, Moulis C, Degott C, Dansette P, Fau D, Pessayre D (1994) Hepatotoxicity of germander in mice. Gastroenterology 106:464–472

    PubMed  CAS  Google Scholar 

  37. Anderson LA (1994) Personal communication, April 13, 1994. London: Medicines Control Agency

    Google Scholar 

  38. De Smet PAGM. Scutellaria species. In: De Smet PAGM, Keller K, Hänsel R, Chandler RF, ed. (1993) Adverse Effects of Herbal Drugs. Volume 2. Heidelberg: Springer-Verlag, pp.289–296

    Google Scholar 

  39. Anderson LA, Doggett NS, Ross MSF (1979) Preparative HPLC of the lipid fraction of Teucrium canadense L. J Liq Chromatogr 2:455–461

    Article  CAS  Google Scholar 

  40. Bruno M, Piozzi F, Savona G, De La Torre MC, Rodríguez B (1989) Neo-clerodane diterpenoids from Teucrium canadense. Phytochemistry 28:3539–3541

    Article  CAS  Google Scholar 

  41. Piozzi F (1981) The diterpenoids of Teucrium species. Heterocycles 15:1489–1503

    Article  CAS  Google Scholar 

  42. Piozzi F, Rodríguez B, Savona G (1987) Advances in the chemistry of the furanoditerpenoids from Teucrium species. Heterocycles 25:807–841

    Article  CAS  Google Scholar 

  43. Penso G (1983) Index Plantarum Medicinalium Totius Mundi Eorumque Synonymorum. Milano: Organizzazione Editoriale Medico Farmaceutica, p. 944

    Google Scholar 

Download references

Authors
  1. P. A. G. M. De Smet
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Royal Dutch Association for the Advancement of Pharmacy, Alexanderstraat 11, 2514 JL, The Hague, The Netherlands

    Peter A. G. M. De Smet

  2. Bundesinstitut für Arzneimittel und Medizinprodukte, Seestraße 10, 13353, Berlin, Germany

    Konstantin Keller

  3. Westpreußenstraße 71, 81927, München, Germany

    Rudolf Hänsel

  4. College of Pharmacy, Dalhousie University, B3H3J5, Halifax, Canada

    R. Frank Chandler

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

De Smet, P.A.G.M. (1997). Teucrium Chamaedrys. In: De Smet, P.A.G.M., Keller, K., Hänsel, R., Chandler, R.F. (eds) Adverse Effects of Herbal Drugs. Adverse Effects of Herbal Drugs, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60367-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60367-9_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60181-4

  • Online ISBN: 978-3-642-60367-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation