Abstract
The pharmacokinetics of 132-hydroxy-bacteriopheophorbid-a methyl ester (132-OH-BPME) and octa-α-butyloxy-zinc phthalocyanme (8-α-bo-Zn-Pc) were studied in mice bearingLewis lung carcinoma. Absorption spectroscopy was used to measure the photosensitizers concentrations. High 132-OH-BPME and 8-α-bo-Zn-Pc uptakes were recorded in the parenchymatous organs (liver, lung), with 8-α-bo-Zn-Pc long retention. The malignant tissues accumulated 132-OH-BPME of more than 20 folds than 8-α-bo-Zn-Pc at all incubation times. 8-α-bo-Zn-Pc concentrations in the skin and the muscle were lower than 132-OH-BPME concentrations at any time period, but also, the 8-α-bo-Zn-Pc retained longer until 168h. PDT with 132-OH-BPME will be more effective than with 8-α-bo-ZnPc since it is accumulated at higher concentrations in the malignant tissues.
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© 1998 Springer-Verlag, Berlin Heidelberg
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Ismail, M.S., Dressler, C., Röder, B., Weitzel, H., Berlien, HP. (1998). Pharmacokinetics Comparison of 132-Hydroxy-Bacteriopheophorbid-A Methyl Ester and Octa-α-Butyloxy-Zinc Phthalocyanine in Mice Bearing Lewis Lung Carcinoma. In: Waidelich, W., Waidelich, R., Waldschmidt, J. (eds) Laser in der Medizin Laser in Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60306-8_47
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DOI: https://doi.org/10.1007/978-3-642-60306-8_47
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