Abstract
The standard theories about the mechanisms involved in PDT concern themselves above all with the oxygen-centred species singlet oxygen (1O2) and the hydroxyl radical (OH) [1–3]. The efficacy of the therapy depends very much on the photosensitizer, choice of irradiation parameters, light source, and the tissue’s degree of oxygenation. Both clinical and experimental studies point to the fact that the treatment of hypoxic areas results in a disappointing response. The radical nature of the products generated in the reactions means that the physical method of choice for research on PDT is electron spin resonance (ESR). The aim of our investigations was to gather information for a comparison of the degrees to which various photosensitizers produce singlet oxygen and hydroxide radicals in vitro. We also investigated the effects of a simple variation in the partial pressure of the dissolved molecular oxygen.
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© 1998 Springer-Verlag, Berlin Heidelberg
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Algermissen, B., Jamil, B., Osterloh, K., Berlien, HP. (1998). The Detection of Oxygen Based Radicals Using Electron Spin Resonance Under PDT Conditions. In: Waidelich, W., Waidelich, R., Waldschmidt, J. (eds) Laser in der Medizin Laser in Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60306-8_45
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DOI: https://doi.org/10.1007/978-3-642-60306-8_45
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