Abstract
Distrubed regulation of cerebral blood flow (CBF), inadequate oxygen delivery, and elevated intracranial pressure all contribute to damage of ischemic stroke. Each of these areas offers a target for intervention in emergency care of stroke. Work examining the interactions between cerebral blood flow, oxygen delivery, brain metabolism, and neuronal injury suggest that there may be better ways to predict the risk of neuronal damage and protect brain tissue. Studies of the mechanisms causing increased intracranial pressure have identified a number of mediators which may become therapeutic targets. These areas are examples of the key role played by basic research into physiological phenomena in our efforts to improve the outcome of ischemic stroke.
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© 1998 Springer-Verlag Berlin Heidelberg
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Diringer, M., Kempski, O. (1998). Pathophysiology of Stroke. In: Steiner, T., Hacke, W., Hanley, D.F. (eds) Stroke. Update in Intensive Care and Emergency Medicine, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60264-1_3
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DOI: https://doi.org/10.1007/978-3-642-60264-1_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64326-2
Online ISBN: 978-3-642-60264-1
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