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Staging of Bladder Cancer

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

In the Western world about 70% of patients with bladder cancer will have a superficial tumor (Tis, Ta, or T1) at first diagnosis, while only 30% will present with muscle-invasive cancer (T2, T3-4, N+, M+) (Steinberg et al. 1992). History, physical examination, urine cytology, intravenous pyelography, and endoscopy, together with adequate tissue sampling by transurethral resection (TUR), are considered to be the cornerstones of the diagnostic armamentarium. Procedures such as bimanual examination, random biopsy, ultrasonography, computer tomography, and bone scintigraphy are considered a routine part of the staging process. The invasive and metastatic behavior of bladder cancer depends on the depth of tumor invasion. We can grossly differentiate superficial tumors, which are only occasionally disseminated at first presentation, from muscle-invasive tumors, which in a significant percentage of cases are accompanied by regional or distant metastases. Both the diagnostic workup and the therapy differ significantly for these two groups, as will be discussed below.

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References

  • Althausen AF, Prout GR, Dalye JJ (1976) Non-invasive papillary carcinoma of the bladder associated with carcinoma in situ. J Urol 116: 575–580

    PubMed  CAS  Google Scholar 

  • Angulo JC, Lopez JI, Gignon DJ, Sanchez-Chapado M (1995) Muscularis mucosa differentiates two populations with different prognosis in stage T1 bladder cancer. Urol 45: 47–53

    Article  PubMed  CAS  Google Scholar 

  • Bellot J, et al. Pathologists of the French Association of Urology Cancer Committee (1993) Lamina propria

    Google Scholar 

  • microinvasion of bladder tumors, incidence on stage allocation (pTa vs pTl): recommended approach. World J Urol 11:161–164

    Google Scholar 

  • Berger GL, Sadlowski RW, Sharpe JR, Finney RP (1981) Lack of value of routine preoperative bone and liver scans in cystectomy candidates. J Urol 125: 637–639

    PubMed  CAS  Google Scholar 

  • Braendengen M, Winderen M, Fossa SD (1996) Clinical significance of routine pre-cystectomy bone scans in patients with muscle-invasive bladder cancer. Br J Urol 77: 36–40

    PubMed  CAS  Google Scholar 

  • Davey P, Merrick MV, Duncan W, Redpath T (1985) Bladder cancer: the value of routine bone scintigraphy. Clin Radiol 36: 77–79

    Article  PubMed  CAS  Google Scholar 

  • Flamm J, Steiner R (1991) Stellenwert der differenzierten transurethralen Resektion beim primären oberflächichen Harnblasenkarizinem. Urologe A 30: 111–113

    PubMed  CAS  Google Scholar 

  • Fossa SD, Ous S, Berner A (1991) Clinical significance of the “palpable mass” in patients with muscle infiltrating bladder cancer undergoing cystectomy after pre-operative radiotherapy. Br J Urol 67: 54–60

    Article  PubMed  CAS  Google Scholar 

  • Giri PG, Walsh JW, Hara TA (1984) Computed tomography in the management of bladder carcinoma. Int J Radiat Oncol Biol Phys 10: 11–21

    Google Scholar 

  • Golding RP, van Zanten TEG, Tierie AH, Batterman JJ, Hart G (1987) Intravenous urography as a prognostic indicator in vesical carcinoma. Cancer 60: 883–886

    Article  PubMed  CAS  Google Scholar 

  • Goris ML, Bretille J (1984) Skeletal scintigraphy for the diagnosis of malignant metastatic disease to the bones. Radiother Oncol 3: 319–329

    Article  Google Scholar 

  • Gospodarowicz MK, Quilty PM, Scalliet P, et al. (1995) The place of radiation therapy as definitive treatment of bladder cancer. Int J Urol 2 (Suppl 2): 41–48

    Article  PubMed  Google Scholar 

  • Grigor KM, Bollina PR (1996) Interpathologist variation in the assessment of G3T1 bladder carcinoma. Eur Urol 30 (Suppl 2): 850

    Google Scholar 

  • Guiliani L, Giberti C, Martorana G, Pizzorno R (1988) Lymphadenectomy during radical cystectomy for bladder cancer. In: Smith PH, Pavone-Macaluso M (eds) Management of advanced cancer of prostate and bladder. Liss, New York, pp 329–339

    Google Scholar 

  • Hatch TR, Barry JM (1986) The value of excretory urography in staging bladder cancer. J Urol 135: 49

    PubMed  CAS  Google Scholar 

  • Herr HW (1988) Bladder cancer: pelvic lymphadenectomy revisted. J Surg Oncol 37: 242

    Article  PubMed  CAS  Google Scholar 

  • Herr HW (1993) Impact of T and N stage on the prognosis of invasive bladder cancer. In: Breul J, Hartung R (eds) Prognostic factors in urological cancers. Zuckschwerdt, München, pp 104–109

    Google Scholar 

  • Herr HW, Withmore WF, Morse MJ, Sogani PC, Russo P, Fair WR (1990) Neoadjuvant chemotherapy in invasive bladder cancer: the evolving role of surgery. J Urol 144: 1083–1088

    PubMed  CAS  Google Scholar 

  • Itzchak Y, Singer D, Fischelowitsch Y (1981) Ultrasonographic assessment of bladder tumors. I. Tumor detection. J Urol 126: 31–33

    PubMed  CAS  Google Scholar 

  • Jakse G, Hofstadter F, Marberger H (1980) Wert der Harnzytologie and Quadrantbiopsie bei oberflachlichen Blasenkarzinom. Akt Urol 11: 309–315

    Article  Google Scholar 

  • Jakse G, Frommhold H, zur Nedden D (1985) Combined radiation and chemotherapy for locally advanced transitional cell carcinoma of the urinary bladder. Cancer 55: 1659–1664

    Article  PubMed  CAS  Google Scholar 

  • Jakse G, Loidl W, Seeber G, Hofstädter F (1987) Stage T1, grade 3 transitional cell carcinoma of the bladder: an unfavorable tumor. J Urol 137: 39–43

    PubMed  CAS  Google Scholar 

  • Jakse G (1996) Personal communication

    Google Scholar 

  • Kiemeney LA, Witjes JA, Heijbroek RP, Koper NP, Verbeek ALM, Dubruyne •• (1994) Should at random urothelial biopsies be taken from patients with primary superficial bladder cancer. Br J Urol 73: 164–170

    Article  PubMed  CAS  Google Scholar 

  • Kishi K, Hirota T, Matsumoto K, Kalazoe T, Murase T, Fujita J (1981) Carcinoma of the bladder: a clinical and pathological analysis of 87 autopsy cases. J Urol 123: 36–39

    Google Scholar 

  • Klän R, Huland H (1990) Residualtumor nath Resektion oberflächlicher Blasentumsren - eine wesentliche Ursache für “Frührezidivë”. Urologe A 29: A18 (Suppl)

    Google Scholar 

  • Klän R, Loy V, Huland H (1991) Residual tumor discovered in routine second transurethral resection in patients with T1 transitional cell carcinoma of the bladder. J Urol 146: 316–318

    PubMed  Google Scholar 

  • Köhrmann KU, Woeste M, Kappes J, Rassweiler J, Alken P (1994) Der Wert der transurethralen Nachresektion beim oberflächlichen Harnblasenkarzinom. Akt Urol 25: 208213

    Google Scholar 

  • Koss JC, Arger PH, Coleman BG, et al. (1981) CT staging of bladder carcinoma. J Urol 137: 359

    CAS  Google Scholar 

  • Kotake T, Flamigan RC, Kirkels WJ, et al. (1995) The current TNM-classification of bladder carcinoma–is it as good as we need it to be? Int J Urol 2 (Suppl 2): 36–40

    Article  PubMed  Google Scholar 

  • Kurth KH, Schellhammer PF, Okajima E, et al. (1992) Current methods of assessing and treating carcinoma in situ of the bladder with or without involvement of the prostatic urethra. Int J Urol 2 (Suppl 2): 8–22

    Article  Google Scholar 

  • Kurth KH, Denis L, Bouffioux C, Sylvester R, Debruyne FMJ, Pavone-Macaluso M, Oosterlinck W (1995) Factors affecting recurrence and progression in superficial bladder tumours. Eur J Cancer 31A: 1840–1846

    Article  Google Scholar 

  • Lerner SP, Skinner DG, Lieskovsky G, et al. (1993) The rationale for en bloc pelvic lymph node dissection for bladder cancer patients with nodal metastases: long-term results. J Urol 149: 758–765

    PubMed  CAS  Google Scholar 

  • Lewis RW, Jackson AC, Murphy WM, Leblane GA, Meehan WL (1976) Cytology in the diagnosis and follow-up of transitional cell carcinoma of the urothelium. A review with a case series. J Urol 116: 43–47

    PubMed  CAS  Google Scholar 

  • Lindner A, DeKernion JB (1982) Cost-effective analysis of pre-cystectomy radioisotope scans. J Urol 128: 1181–1182

    PubMed  CAS  Google Scholar 

  • Malkowicz SB, Skinner DG (1990) Development of upper urinary tract carcinoma after cystectomy for bladder carcinoma. Urology 36: 20

    Article  PubMed  CAS  Google Scholar 

  • Marshall VF (1952) The relation of the pre-operative estimate to the pathologic demonstration of the extent of vesical neoplasms. J Urol 68: 714–723

    PubMed  CAS  Google Scholar 

  • Matzkin H, Soloway MA, Hardeman S (1991) Transitional cell carcinoma of the prostate. J Urol 146: 1207–1212

    PubMed  CAS  Google Scholar 

  • McNeil BJ (1984) Value of bone scanning in neoplastic disease. Semin Nucl Med XIV: 277–286

    Google Scholar 

  • Miller RS, Freiha FS, Reese JH, Ozen H, Torti FM (1993) Cisplatin, methotrexate and vinblastine plus surgical restaging for patients with advanced transitional cell carcinoma of the urothelium. J Urol 150: 65–69

    PubMed  CAS  Google Scholar 

  • Neuerburg JM, Bohndorf K, Sohn M, Feul F, Günther RW (1991) Staging of urinary bladder neoplasms with MR imaging. Is Gd. PTPA helpful? J Comput Assist Tomogr 15: 780–786

    Article  PubMed  CAS  Google Scholar 

  • Ooms ECM, Anderson WAD, Alons CL, Boon M, Veldhuizen RW (1983) Analysis of the performance of pathologist in the grading of bladder tumors. Hum Pathol 14: 140–143

    Article  PubMed  CAS  Google Scholar 

  • Oosterlinck W, Kurth KH, Schröder F, Bultinck J, Hammond B, Sylvester R and members of the European Organization for Research and Treatment of Cancer Genitourinary Group (1993) A prospective European organization for research and treatment of cancer genitourinary group randomized trial comparing transurethral resection followed by a single intravesical instillation of epirubicin or water in single stage Ta, T1 papillary carcinoma of the bladder. J Urol 149: 749–752

    PubMed  CAS  Google Scholar 

  • Pagano F, Bassi P, Drago Ferrante LD, Piazza N, Abatangelo G, Pappagallo GL, Garbeglio A (1996) Is stage pT4a ( D) reliable in assessing transitional cell carcinoma involvement of the prostate in patients with a concurrent bladder cancer? A necessary distinction for contiguous or noncontiguous involvement. J Urol 155: 244–247

    Article  PubMed  CAS  Google Scholar 

  • Palou J, Farina LA, Villavicencio H, Vicente J (1992) Upper tract urothelial tumor after transurethral resection of bladder tumor. Eur Urol 21: 110–114

    PubMed  CAS  Google Scholar 

  • Parmar MKB, Freedman LS, Hargreave TB, Tolley DA (1989) Prognostic factors for recurrence and follow-up policies in the treatment of superficial bladder cancer: report from the British Medical Research Council subgroup on superficial bladder cancer (urological cancer working party). J Urol 142: 284–288

    PubMed  CAS  Google Scholar 

  • Paulson D, Denis L, Orikasa S, et al. (1995) Optimal staging procedures, including imaging, to define prognosis of bladder cancer. Int J Urol 2 (suppl 2): 1–7

    Article  PubMed  Google Scholar 

  • Pedrazzini A, Gelber R, Isley M, Castiglione M, Goldhirsch A (1996) First repeated bone scan in the observation of patients with operable breast cancer. J Clin Oncol 4: 389–394

    Google Scholar 

  • Prout GR Jr, Kotake T, Pavone-Maculaso M, et al. (1993) TNM classification of bladder carcinoma. In: Consensus development in clinical bladder cancer research. Proceedings of the second and third international consensus development conferences. 1: 259–265

    Google Scholar 

  • Ro JY, Ayala AG, El-Naggar A (1987) Muscularis mucosa of urinary bladder: importance of staging and treatment. Am J Surg Pathol 11: 668–673

    Article  PubMed  CAS  Google Scholar 

  • Ro JY, Staerkel GA, Ayala AG (1992) Cytologic and histologic features of superficial bladder cancer. Urol Clin North Am 19: 435–455

    PubMed  CAS  Google Scholar 

  • Sawczuk IS, de Vere White R, Gole RP, et al. (1983) Sensitivity of computed tomography in evaluation of pelvic lymph node metastases from carcinoma of the bladder and prostate. Urology 21: 81

    Article  PubMed  CAS  Google Scholar 

  • Schulze S, Holm-Mielsen A, Mogensen P (1991) Transurethral ultrasound scanning in the evaluation of invasive bladder cancer. Scand J Urol Nephrol 25: 215–217

    Article  PubMed  CAS  Google Scholar 

  • See WA, Fuller JR (1992) Staging of advanced bladder cancer. Urol Clin North Am 19: 455

    Google Scholar 

  • Shipley WU, Rose MA, Perrone TL, Mannix CM, Heney NM, Prout GR (1985) Full-dose irradiation for patients with invasive bladder carcinoma: clinical and histological factors prognostic of improved survival. J Urol 134: 679–683

    PubMed  CAS  Google Scholar 

  • Steinberg GD, Trump DL, Cummings KB (1992) Staging ad- vanced bladder cancer. Urol Clin North Am 19: 735–746

    PubMed  CAS  Google Scholar 

  • Sternberg CN, Yagoda A, Scher HI, et al. (1989) MVAC for advanced transitional cell carcinoma of the urothelium: efficacy and pattern of response. Cancer 64: 2448–2458

    Article  PubMed  CAS  Google Scholar 

  • Stöckle M, Meyenburg W, Wellek S, et al. (1992) Advanced bladder carcinoma. Improved survival rates after radical cystectomy and 3 cycles of adjuvant chemotherapy. Results of a controlled prospective study. J Urol 302–307

    Google Scholar 

  • Utz CC, Farrow GM (1984) Carcinoma in situ of the urinary tract. Urol Clin North Am 11: 735

    PubMed  CAS  Google Scholar 

  • van Poppel H, Ameye F, Oyen R, van de Voorde W, Baert L (1994) Accuracy of combined computerized tomography and fine needle aspiration cytology in lymph node staging of localized prostatic carcinoma. J Urol 151: 1310–1314

    Google Scholar 

  • Vincente J, Laguna MP, Duarte D, Algaba F, Chechile G (1991) Carcinoma in situ as a prognostic factor in G3pT1 bladder tumors. Br J Urol 68: 380–382

    Article  Google Scholar 

  • Vlachos L, Trakadas S, Gouliamos A, et al. (1990) Comparative study between ultrasound, computed tomography intraarterial digital subtraction angiography and magnetic resonance imaging the differentiation of tumors of the liver. Gastrointest Radiology 15: 102–106

    Article  CAS  Google Scholar 

  • Vock P, Haeertel M, Fuchs WA, et al. (1982) Computed tomography in staging of carcinoma of the urinary bladder. Br J Urol 54: 158

    Article  PubMed  CAS  Google Scholar 

  • Vögeli TA, Marx G, Ackermann R (1992) Zur Notwendigkeit der Nachresektion beim urothelialen Blasenkarzinom als Kontrolle der Erstresektion. Urologe A: A59 (Suppl)

    Google Scholar 

  • Voges GE, Tauschke E, Söckle M, Alken M, Hohenfellner R (1989) Computerized tomography: an unreliable method for accurate staging of bladder tumors in patients who are candidates for radical cystectomy. J Urol 142: 972–974

    PubMed  CAS  Google Scholar 

  • Weinerman PM, Arger PH, Polloch HM (1982) CT evaluation of bladder and prostate neoplasms. Urol Radiol 4: 105

    Article  PubMed  CAS  Google Scholar 

  • Wishnow KI, Tenney DM (1991) Radical cystectomy for invasive bladder cancer. Urol Clin North Am 18: 529–537

    PubMed  CAS  Google Scholar 

  • Younes M, Sussmann J, True LD (1990) The usefulness of the level of the muscularis mucosa in the staging of invasive transitional cell carcinoma of the urinary bladder. Cancer 66: 543–548

    Article  PubMed  CAS  Google Scholar 

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© 1998 Springer-Verlag Berlin Heidelberg

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Ijzerman, W., Jung, P., Jakse, G. (1998). Staging of Bladder Cancer. In: Petrovich, Z., Baert, L., Brady, L.W. (eds) Carcinoma of the Bladder. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60258-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-60258-0_8

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