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Continuous Infusion Chemotherapy and Irradiation in the Treatment of Advanced Bladder Carcinoma

  • Chapter
Carcinoma of the Bladder

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Despite the extensive surgery involved in radical cystectomy in the treatment of muscle-invading bladder carcinoma, the procedure is unable to provide a 5-year survival rate of more than 26%–40% (Montie et al. 1984; Polle-Wilson and Barnard 1971). Patients thus treated suffer from loss of bladder function, the need for constant maintenance of the associated urinary diversion, and loss of sexual function and its accompanying psychological trauma. Although the use of preoperative radiation therapy has added another 10%–15% (Batata et al. 1981; Bloom et al. 1982; Vieti et al. 1971) to the 5-year survival rate, loss of bladder function and loss of sexual function remain problems that cannot be ignored. Thus, there has been a continued search for a therapeutic solution that would allow sparing of the bladder without compromising survival in patients with invasive tumors.

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References

  • Arcangeli G, Tirindelli-Danesi D, Mecozzi, A, Saracino B, Cruciani E (1996) Combined hyperfractionated irradiation and protracted infusion chemotherapy in invasive bladder cancer with conservative intent. Phase I study. Int J Radiat Oncol Biol Phys 36:314

    Article  Google Scholar 

  • Bagshaw MA (1961) Possible role of potentiators in radiation therapy. Am J Roentgenol 85:822

    CAS  Google Scholar 

  • Batata MA, Chi FCH, Hilaris BS, et al. (1981) Preoperative whole pelvis versus true pelvis irradiation and/or cystectomy for bladder cancer. Int J Radiat Oncol Biol Phys 7:1349

    Article  PubMed  CAS  Google Scholar 

  • Beahrs OH, Henson DE, Hutter DE, Myers MH (eds) (1983) American Joint Committee on cancer manual for staging for cancer, 3rd edn. Lippincott, Philadelphia

    Google Scholar 

  • Blandy JP, England HR, Evans SJ, et al. (1980) T3 bladder cancer, the case for salvage cystectomy. Br J Urol 52:506

    Article  PubMed  CAS  Google Scholar 

  • Bloom HJ, Hendry WF, Wallace DM, et al. (1982) Treatment of T3 bladder cancer. Controlled trial of preoperative radiotherapy and radical cystectomy versus radical radiotherapy. Second report and review (for the Clinical Trial Group Inst. of Urology). Br J Urol 54:136

    Article  PubMed  CAS  Google Scholar 

  • Byfield JE, Chan, P, Seagren SL (1977) Radiosensitization of 5-FU: molecular origins and clinical scheduling implications. Proc Am Assoc Cancer Res 18:74

    Google Scholar 

  • Chabner B (1982) Pharmacologic principles of cancer treatment. Saunders, Philadelphia

    Google Scholar 

  • Eapen L, Stewart D, Danjoix D, et al. (1989) Intraarterial cisplatin and concomitant radiation for locally advanced bladder cancer. J Clin Oncol 7:230–233

    PubMed  CAS  Google Scholar 

  • Goodman GB, Hislop TG, Elwood JM, et al. (1982) Conservation of bladder function in patients with invasive bladder cancer treated by definitive irradiation and selective cystectomy. Int J Radiat Oncol Biol Phys 7:569

    Google Scholar 

  • Heidelberger C, Greishbach L, Montag B, et al. (1958) Studies in fluorinated pyrimidine. II. Effects of transplanted tumor. Cancer Res 18:305–317

    PubMed  CAS  Google Scholar 

  • Hope-Stone HF, Blandy JP, Oliver RTD, et al. (1981) Radical radiotherapy and salvage cystectomy in the treatment of invasive carcinoma of the bladder. In: Oliver RTD, Hendry WF, Bloom HJ (eds) Bladder cancer: principles of combination therapy. Butterworth, London, pp 127–138

    Google Scholar 

  • Jewett HJ, Strong GH (1946) Infiltrating carcinoma of the bladder: relation of depth of penetration of the bladder wall to incidence of local extension and metastases. J Urol 55:366

    PubMed  CAS  Google Scholar 

  • Kaufman DS, Shipley WU, Griffin PP, et al. (1993) Selective bladder preservation by combination treatment of invasive bladder cancer. N Engl J Med 329:1377

    Article  PubMed  CAS  Google Scholar 

  • Lo TCM, Wiley AL, Ausfield FJ, et al. (1976) Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study. Radiology 126:229

    CAS  Google Scholar 

  • Lockich JJ (1984) Infusion chemotherapy for cancer. Current Concepts Oncol 6:3

    Google Scholar 

  • Miller LS, Johnson DE (1973) Megavoltage irradiation for bladder cancer: alone, postoperative or preoperative? Genit Cancer 10:771

    Google Scholar 

  • Moertel CG, Childs DS, Reitemeier RJ, et al. (1969) Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastro-intestinal cancer. Lancet II:865

    Article  Google Scholar 

  • Montie JE, Straffon RA, Stewart BH (1984) Radical cystectomy without radiation therapy for carcinoma of the bladder. J Urol 131:477

    PubMed  CAS  Google Scholar 

  • Poole-Wilson DS, Barnard RJ (1971) Total cystectomy for bladder tumors. Br J Urol 43:16

    Article  PubMed  CAS  Google Scholar 

  • Prout GR, Griffin PP, Shipley WU (1979) Bladder carcinoma as a systemic disease. Cancer 43:2532

    Article  PubMed  Google Scholar 

  • Quilty PM, Duncan W (1986) Primary radical radiotherapy for T3 transitional cell cancer of the bladder. An analysis of survival and control. Int J Radiat Oncol Biol Phys 12:853

    Article  PubMed  CAS  Google Scholar 

  • RTOG 77–05/81–10: Phase I, II, study comparing the value of neutrons alone, mixed beam and preoperative mixed beam in bladder carcinoma. RTOG, Philadelphia, Pa

    Google Scholar 

  • RTOG 81–05: Phase I/II study on the value of combining misonidazole and radiotherapy in the treatment of bladder cancer. RTOG, Philadelphia, Pa

    Google Scholar 

  • RTOG 83–08: Randomized phase II study to evaluate hyperfractionated radiation for locally advanced carcinoma of the bladder. RTOG, Philadelphia, Pa

    Google Scholar 

  • Raghavan D, Shipley WU, Garnick MB, et al. (1990) Biology and management of bladder cancer. N Engl J Med 322:1129

    Article  PubMed  CAS  Google Scholar 

  • Rotman M, Aziz H, Porrazzo M, et al. (1990) Treatment of advanced transitional cell carcinoma of the bladder with irradiation and concomitant 5-fluorouracil infusion. Int J Radiat Oncol Biol Phys 18:1131

    Article  PubMed  CAS  Google Scholar 

  • Russel KJ, Boileau MA, Ireton RC, et al. (1988) Transitional cell carcinoma of the urinary bladder; histologic clearance with combined 5-FU chemotherapy and radiation therapy. Preliminary results of bladder preservation study. Radiology 167:845

    Google Scholar 

  • Scher H, Hess H, Sternberg C, et al. (1989) Neoadjuvant chemotherapy for invasive bladder cancer. Experience with M-VAC regimen. Br J Urol 64:250

    Article  PubMed  CAS  Google Scholar 

  • Seifert P, Baker LH, Reed ML, et al. (1975) Comparison of continuous infused 5-Fu with bolus injection in treatment of patients with colo-rectal adenocarcinoma. Cancer 36:123–128

    Article  PubMed  CAS  Google Scholar 

  • Shipley WU, Coombs LJ, Einstein AB, Jr, et al. (1984) National Bladder Cancer Collaborative Group: cisplatin and full dose irradiation for patients with invasive bladder carcinoma: a preliminary report of tolerance and local response. J Urol 132:899

    PubMed  CAS  Google Scholar 

  • Shipley WU, Kaufman D, Griffin P, et al. (1992) Radio-chemotherapy for invasive carcinoma of the bladder. In: Vaeth JM (ed) Radiotherapy/chemotherapy interaction in cancer therapy. Karger, Basel

    Google Scholar 

  • Stein JJ, Kaufman JJ (1968) Treatment of carcinoma of the bladder with special reference to the use of preoperative radiation therapy combined with 5-FU. Am J Roentgenol Radium Ther Nod Med 102:519–529

    CAS  Google Scholar 

  • Van der Werf-Messing BHP, Friedal GH, Menon RS, et al. (1982) Carcinoma of the urinary bladder T3NXMO treated by preoperative irradiation followed by simple cystectomy. Int J Radiat Oncol Biol Phys 8:1849

    Article  PubMed  Google Scholar 

  • Vietti J, Eggerding F, Valeriote F (1971) Combined effect of radiation and 5-fluorouracil on survival of transplanted leukemia cells. J Natl Cancer Inst 47:865

    PubMed  CAS  Google Scholar 

  • Woodruff MW, Murphy WT, Hodson JM (1963) Further observations on the use of combination 5-fluorouracil and supervoltage irradiation therapy in the treatment of advanced carcinoma of the bladder. J Urol 90:747

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, SUNY Health Sciences Center @ Brooklyn, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA

    M. Rotman MD (Professor and Chairman), H. Aziz MD, D. Schwartz MD, J. Cirrone MD, A. Schulsinger MD & K. Choi MD

  2. Department of Urology, SUNY Health Sciences Center @ Brooklyn, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA

    R. Macchia MD

Authors
  1. M. Rotman MD
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  2. H. Aziz MD
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  3. D. Schwartz MD
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  4. J. Cirrone MD
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  5. A. Schulsinger MD
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  6. K. Choi MD
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  7. R. Macchia MD
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Southern California, USC/Norris Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA, 90033, USA

    Zbigniew Petrovich MD, FACR (Professor and Chairman) (Professor and Chairman)

  2. Department of Urology, UZ Gasthuisberg, University of Leuven, Herestraat 49, B-3000, Leuven, Belgium

    Luc Baert MD, PhD (Professor and Chairman) (Professor and Chairman)

  3. Department of Radiation Oncology and Nuclear Medicine, Allegheny University Hospitals, Center City, Mail Stop 200, Broad & Vine Sts., Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Professor) (Professor)

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© 1998 Springer-Verlag Berlin Heidelberg

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Rotman, M. et al. (1998). Continuous Infusion Chemotherapy and Irradiation in the Treatment of Advanced Bladder Carcinoma. In: Petrovich, Z., Baert, L., Brady, L.W. (eds) Carcinoma of the Bladder. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60258-0_21

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  • DOI: https://doi.org/10.1007/978-3-642-60258-0_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64323-1

  • Online ISBN: 978-3-642-60258-0

  • eBook Packages: Springer Book Archive

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