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Pokeweed Antiviral Protein and Its Applications

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Plant Biotechnology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 240))

Abstract

The genus Phytolacca produces a number of proteins that have antiviral properties. These antiviral proteins are ribosome-inactivating proteins (RIPs) which remove a single adenine from a highly conserved, surface-exposed, stem-loop structure in the large rRNA of eukaryotic and prokaryotic ribosomes. They are found in two general forms: dimeric toxins (type II) containing a cell binding protein linked to the RIP by a disulfide bond, and single chain RIPs (type I), such as those found in pokeweed, composed of a single chain. A number of single-chain RIPs have been isolated from leaves, seeds and roots of a wide variety of plants (for reviews see Irvin and Uckun 1992; Irvin 1995).

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  1. N. E. Tumer
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  2. K. Hudak
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  3. R. Di
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  4. C. Coetzer
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  5. P. Wang
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  6. O. Zoubenko
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Editors and Affiliations

  1. Florist and Nursery Crops Unit, USDA-ARS, USNA, Rm. 238, B-010A, 10300 Baltimore Ave., 20705, Beltsville, MD, USA

    John Hammond Ph.D.

  2. National Biomedical Research Foundation, Georgetown University Medical Center, LR-3, Preclinical Science Building, 3900 Reservoir Road, NW, Washington, DC, 20007, USA

    Peter McGarvey Ph.D.

  3. Biotechnology Foundation Labs., Thomas Jefferson University, Rm. M85, JAH, 1020 Locust Street, 19107, Philadelphia, PA, USA

    Vidaldi Yusibov Ph.D.

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Tumer, N.E., Hudak, K., Di, R., Coetzer, C., Wang, P., Zoubenko, O. (2000). Pokeweed Antiviral Protein and Its Applications. In: Hammond, J., McGarvey, P., Yusibov, V. (eds) Plant Biotechnology. Current Topics in Microbiology and Immunology, vol 240. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60234-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-60234-4_7

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