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Use of Calcium Antagonists After Myocardial Infarction: Focus on the DEFIANT Studies

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Abstract

The potential advantages of calcium antagonists in patients recovering from acute myocardial infarction include their potent systemic and coronary vasodilator properties, the anti-arrhythmic properties of drugs such as verapamil and diltiazem, and the possible beneficial effect of calcium channel blocking drugs on myocardial calcium handling and ventricular diastolic function [1]. To minimize the myocardial depressant effect which characterized the first-generation calcium antagonists [2–5], second and third-generation vasoselective drugs with enhanced safety profile and a longer duration of action were developed [6]. The newer calcium antagonists may be associated with a more favorable neurohormonal profile [7–9].

Keywords

Acute Myocardial Infarction Calcium Antagonist Diastolic Ventricular Function Secondary Prevention Reinfarction Israeli Nifedipine Trial Ventricular Loading Condition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1999

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