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Use of Calcium Antagonists After Myocardial Infarction: Focus on the DEFIANT Studies

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Nisoldipine Coat-Core

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Abstract

The potential advantages of calcium antagonists in patients recovering from acute myocardial infarction include their potent systemic and coronary vasodilator properties, the anti-arrhythmic properties of drugs such as verapamil and diltiazem, and the possible beneficial effect of calcium channel blocking drugs on myocardial calcium handling and ventricular diastolic function [1]. To minimize the myocardial depressant effect which characterized the first-generation calcium antagonists [2–5], second and third-generation vasoselective drugs with enhanced safety profile and a longer duration of action were developed [6]. The newer calcium antagonists may be associated with a more favorable neurohormonal profile [7–9].

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Authors
  1. Amnon Merdler
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  2. David A. Halon
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  3. Moshe Y. Flugelman
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  4. Basil S. Lewis
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Editor information

Editors and Affiliations

  1. Division of Cardiology, University of Louvain, Avenue Hippocrate 10/2800, B-1200, Bruxelles, Belgium

    Michel F. Rousseau

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© 1999 Springer-Verlag Berlin Heidelberg

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Merdler, A., Halon, D.A., Flugelman, M.Y., Lewis, B.S. (1999). Use of Calcium Antagonists After Myocardial Infarction: Focus on the DEFIANT Studies. In: Rousseau, M.F. (eds) Nisoldipine Coat-Core. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60220-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-60220-7_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66049-1

  • Online ISBN: 978-3-642-60220-7

  • eBook Packages: Springer Book Archive

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