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Neue Methoden und Ergebnisse bei der molekularen Genetik schwerer psychischer Erkrankungen

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Zusammenfassung

Die vergleichsweise neuen Disziplinen der molekularen Genetik und der molekularen Biologie haben die Forschung in Biologie und Medizin revolutioniert. Zumindest eine gewisse Vertrautheit mit diesen Fächern ist heute eine Voraussetzung, um die Inhalte von beinahe jeder biomedizinischen Fachzeitschrift lesen und verstehen zu können. Jede Woche werden Krankheitsgene kartiert oder identifiziert, und es wird erwartet, daß in naher Zukunft diese Fülle an positioneller und struktureller genetischer Information in detaillierte funktionelle Daten übersetzt wird, die die Ätiologie bisher kaum verstandener Erkrankungen enträtseln und letztlich zu Verbesserungen bei der Behandlung führen werden.

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Literatur

  • Baron M, Freimer NF, Risch N et al. (1993) Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nat Genet 3: 49–55

    Article  PubMed  CAS  Google Scholar 

  • Berrettini WH, Ferraro TN, Goldin LR et al. (1994 a) Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 91:5918–5921

    Article  PubMed  CAS  Google Scholar 

  • Berrettini WH, Ferraro TN, Alexander RC (1994 b) Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Nat Genet 7:54–58

    Article  PubMed  CAS  Google Scholar 

  • Blackwood DHR, He L, Morris SW et al. (1996) A locus for bipolar affective disorder on chromosome 4p. Nat Genet 12: 427–430

    Article  PubMed  CAS  Google Scholar 

  • Flint J, Corley R, DeFries JC et al. (1995) A simple genetic basis for a complex psychological trait in laboratory mice. Science 269: 1432–1435

    Article  PubMed  CAS  Google Scholar 

  • Frankel WN (1995) Taking stock of complex trait genetics in mice. Trends Genet 11: 471–477

    Article  PubMed  CAS  Google Scholar 

  • Freimer NB, Reus VI, Escamilla MA et al. (1996) Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23. Nat Genet 12: 436–441

    Article  PubMed  CAS  Google Scholar 

  • Gershon ES, Badner JA, Detera-Wadleigh SD et al. (1996) Maternal inheritance and chromosome 18 allele sharing in unilineal bipolar illness pedigrees. Am J Med Genet (Neuropsychiatr Genet) 67: 202–207

    Article  CAS  Google Scholar 

  • Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11: 241–247

    Article  PubMed  CAS  Google Scholar 

  • Leboyer M, Malafosse A, Boulamargin S et al. (1990) Tyrosine hydroxylase polymorphisms associated with manic-depressive illness. Lancet 335: 1219

    Article  PubMed  CAS  Google Scholar 

  • Lesch KP, Bengel D, Heils A et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527–1531

    Article  PubMed  CAS  Google Scholar 

  • Lovett M (1994) Fishing for complements: finding genes by direct selection. Trends Genet 10: 352–357

    Article  PubMed  CAS  Google Scholar 

  • McGuffin P, Owen MJ, O’Donovan MC, Thapar A, Gottesman II (1994) Seminars in psychiatric genetics. Gaskell, London

    Google Scholar 

  • Mendelbaum K, Sevy S, Souery D (1995) Manic-depressive illness reanalysis in the Xq27-Xq28 region of chromosome X. Neuro-psychobiology 31: 58–63

    CAS  Google Scholar 

  • Moises HW, Yang L, Li T et al. (1995) Potential linkage disequilibrium between schizophrenia and locus D22S278 on the long arm of chromosome 22. Am J Med Genet (Neuropsychiatr Genet) 60: 465–467

    Article  CAS  Google Scholar 

  • O’Donovan MC, Owen M (1992) Advances and retreats in the molecular genetics of major mental illness. Ann Med 24: 171–177

    Article  PubMed  Google Scholar 

  • O’Donovan MC, Owen MJ (1996 a) Dynamic mutations and psychiatric genetics. Psychol Med 26:1–6

    Google Scholar 

  • O’Donovan MC, Owen MJ (1996 b) The molecular genetics of schizophrenia. Ann Med 28:541–546

    Google Scholar 

  • O’Donovan MC, Guy C, Craddock N et al. (1996) Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychol Med 26: 1145–1153

    Article  PubMed  Google Scholar 

  • Ogilvie AD, Battersby S, Bubb VJ (1996) Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347: 731–3

    Article  PubMed  CAS  Google Scholar 

  • Pekkarinen P, Terwilliger J, Bredbacka PE et al. (1996) Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree. Genome Res 5: 105–115

    Article  Google Scholar 

  • Reich T, Clayton PJ, Winokur G (1969) Family history studies, V. The genetics of mania. Am J Psychiatry 125: 1358–1369

    PubMed  CAS  Google Scholar 

  • Risch N, Botstein D (1996) A manic depressive history. Nat Genet 12: 351–353

    Article  PubMed  CAS  Google Scholar 

  • Schizophrenia Collaborative Research Group (1996) A combined analysis of D22S278 marker alleles in affected sib-paris: support for a susceptibility locus for schizophrenia at chromosome 22q12. Am J Med Genet (Neuropsychiatr Genet) 67: 40–45

    Article  Google Scholar 

  • Schuler GD, Bosuski MS, Stewart EA et al. (1996) A gene map of the human genome. Science 274: 540–546

    Article  PubMed  CAS  Google Scholar 

  • Spielman RS, Ewens WJ (1996) The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59: 983–989

    PubMed  CAS  Google Scholar 

  • Stine OC, Xu J, Koskela R et al. (1995) Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet 57: 1384–1394

    PubMed  CAS  Google Scholar 

  • Straub RE, MacLean CJ, O’Neill FA et al. (1995) A potential vulnerability locus for schizophrenia on chromosome 6p24-24: evidence for genetic heterogeneity. Nat Genet 11: 287–293

    Article  PubMed  CAS  Google Scholar 

  • Vellada H, Curtis D, Sham PC et al. (1995) Chromosome 22 markers demonstrate transmission disequilibrium with schizophrenia. Psychiatr Genet 5: 127–130

    Article  Google Scholar 

  • Wang S, Sun CE, Walczak CA et al. (1995) Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat Genet 10: 41–46

    Article  PubMed  Google Scholar 

  • Williams J, Spurlock G, McGuffin P et al. (1996) Association between schizophrenia and T102 C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. Lancet 347: 1294–1296

    PubMed  CAS  Google Scholar 

  • Williams J, Spurlock G, Holmans P et al. (1998) A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Psychiatr Genet 3: 141–149

    CAS  Google Scholar 

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© 1999 Springer-Verlag Berlin Heidelberg

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O’Donovan, M.C., McGuffin, P. (1999). Neue Methoden und Ergebnisse bei der molekularen Genetik schwerer psychischer Erkrankungen. In: Helmchen, H., Henn, F., Lauter, H., Sartorius, N. (eds) Psychiatrie der Gegenwart 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60174-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-60174-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64290-6

  • Online ISBN: 978-3-642-60174-3

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