Abstract
Upon generation in the fetal liver and adult bone marrow, B lymphocytes are selected into a long-lived pool that participates in the immune response against exogenous antigens. Processes leading to the generation of long-lived naive B cells are still poorly understood, but it is clear that they include the selection of particular clones over others depending on receptor specificity and individual micro-environmental experiences.
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References
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© 1999 Springer-Verlag Berlin Heidelberg
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Martin, F., Kearney, J.F. (1999). CD21highIgMhigh Splenic B Cells Enriched in the Marginal Zone: Distinct Phenotypes and Functions. In: Melchers, F., Potter, M. (eds) Mechanisms of B Cell Neoplasia 1998. Current Topics in Microbiology and Immunology, vol 246. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60162-0_6
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DOI: https://doi.org/10.1007/978-3-642-60162-0_6
Publisher Name: Springer, Berlin, Heidelberg
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