Abstract
The regulation of leukocyte migration is a complex process involving the participation of adhesion molecules, such as selectins and integrins, as well as chemokines and chemokine receptors (Baggiolini, 1998, Butcher & Picker, 1996). The combined action of adhesion molecules and chemokines is though to provide an address code for leukocyte extravasation and migration into tissues (Springer, 1994). The immune response strictly depends on the correct positioning of leukocytes at distinct anatomical sites. T cell priming occurs in the specialized confines of lymphoid tissue and requires the encounter of T cells with antigen- loaded dendritic cells (Banchereau & Steinman, 1998). Conversely, delayed type hypersensitivity or allergic reactions can occur in any tissue and result from the coordinated action of T helper (Th)l or Th2 cells and effector leukocytes such as macrophages, basophils and eosinophils (Mosmann & Coffman, 1989, Paul & Seder, 1994, Romagnani, 1991).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Baggiolini, M. (1998). Chemokines and leukocyte traffic. Nature 392, 565 – 568
Baggiolini, M. & Moser, B. (1997). Blocking chemokine receptors. J. Exp. Med. 186, 1189 – 1191
Banchereau, J. & Steinman, R. M. (1998). Dendritic cells and the control of immunity. Nature 392, 245 – 252
Bonecchi, R., Bianchi, G., Bordignon, P. P., D’Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A. & Sinigaglia, F. (1998). Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (This) and Th2s. J Exp Med 187, 129 – 34
Butcher, E. C. & Picker, L. J. (1996). Lymphocyte homing and homeostasis. Science 272, 60 – 6
Corrigan, C. J. & Kay, A. B. (1992). T cells and eosinophils in the pathogenesis of asthma. Immunol Today 13, 501 – 507
Gerber, B., Zanni, M. P., Uguccioni, M., Loetscher, M., Mackay, C. R., Pichler, W. J., Yawalkar, N., Baggiolini, M. & Moser, B. (1997). Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localising with eosinophils. Curr. Biol. 7, 836 – 843
Loetscher, P., Uguccioni, M., Bordoli, L., Baggiolini, M., Moser, B., Chizzolini, C. & Dayer, J. M. (1998). CCR5 is characteristic of Thl lymphocytes. Nature 391, 344 – 345
Mosmann, T. R. & Coffman, R. L. (1989). TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7, 145 – 73
Paul, W. E. & Seder, R. A. (1994). Lymphocyte responses and cytokines. Cell 76, 241–245
Ponath, P. D., Qin, S., Post, T. W., Wang, J., Wu, L., Gerard, N. P., Newman, W., Gerard, C. & Mackay, C. R. (1996). Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J. Exp. Med. 183, 2437 – 2448
Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B. & Mackay, C. R. (1998a). The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 101, 746 – 754
Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, M. & MacKay, C. (1998b). The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J. Clin. Invest. 101, 746 – 754
Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D. H., Gubler, U. & Sinigaglia, F. (1997). Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med 185, 825 – 831
Romagnani, S. (1991). Human TH1 and TH2 subsets: doubt no more. Immunol Today 12, 256 – 257
Sad, S. & Mosmann, T. R. (1994). Single IL-2-secreting precursor CD4 T cell can develop into either Thl or Th2 cytokine secretion phenotype. J Immunol 153, 3514 – 3522
Sallusto, F., Lenig, D., Mackay, C. R. & Lanzavecchia, A. (1998). Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187, 875 – 883
Sallusto, F., Mackay, C. R. & Lanzavecchia, A. (1997). Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277, 2005–2007
Springer, T. A. (1994). Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301 – 314
Uguccioni, M., Mackay, C. R., Ochensberger, B., Loetscher, P., Rhis, S., LaRosa, G. J., Rao, P., Ponath, P. D., Baggiolini, M. & Dahinden, C. A. (1997). High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. J. Clin. Invest. 100, 1137 – 1143
Wu, L., Paxton, W. A., Kassam, N., Ruffing, N., Rottman, J. B., Sullivan, N., Choe, H., Sodroski, J., Newman, W., Koup, R. A. & Mackay, C. R. (1997). CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J. Exp. Med. 185, 1681 – 1691.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sallusto, F., Palermo, B., Hoy, A., Lanzavecchia, A. (1999). The Role of Chemokine Receptors in Directing Traffic of Naive, Type 1 and Type 2 T Cells. In: Melchers, F., Potter, M. (eds) Mechanisms of B Cell Neoplasia 1998. Current Topics in Microbiology and Immunology, vol 246. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60162-0_16
Download citation
DOI: https://doi.org/10.1007/978-3-642-60162-0_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64283-8
Online ISBN: 978-3-642-60162-0
eBook Packages: Springer Book Archive