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Bone

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 135 / 2))

Abstract

The skeleton, composed of bone and cartilage, protects vital organs including hematopoietic bone marrow and serves as a reservoir for fundamental ions, especially calcium, magnesium and phosphorus. Furthermore, the skeleton supports and possesses sites for muscle attachment.

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References

  • Baron RE (1996) Anatomy and ultrastructure of bone. In: Favus, MJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 3rd edn. Lippencott-Raven, Philadelphia, pp 3–10

    Google Scholar 

  • Baron R, Neff L, Louvard D, Courtoy PJ(1985)Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in the resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J Cell Bioi 101:2210–2222

    Article  CAS  Google Scholar 

  • Benz DJ, Haussler MR, Komm BS (1991) Estrogen binding and estrogenic responses in normal human osteoblast-like cells. J Bone Miner Res 6:531–541

    Article  PubMed  CAS  Google Scholar 

  • Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA (1996) Proteolytic activity of human osteoclast cathepsin K: expression, purification, activation, and substrate identification. J Bioi Chern 271:12517–12524

    Article  CAS  Google Scholar 

  • Calvo MS, Eyre DR, Gundberg CM (1996) Molecular basis and clinical application of biological markers of bone turnover. Endocr Rev 17:333–368

    PubMed  CAS  Google Scholar 

  • Christiansen C, Christensen MS, Transbol I(1981)Bone mass in postmenopausal women after withdrawal of estrogenigestagen replacement therapy Lancet 1:459–461

    Article  PubMed  CAS  Google Scholar 

  • Delaisse JM, Eeckhout Y, Vaes G(1984) In vivo and in vitro evidence for the involvement of cysteine-proteinase in bone resorption. Biochem Biophys Res Commun 125:441–447

    Article  PubMed  CAS  Google Scholar 

  • Delaisse JM, Boyde A, Maconnachie E, Ali NN, Sear CHJ, Eeckhout Y, Vaes G, Jones SJ(1987)The effects of inhibitors Jones of cysteine-proteases and collagenase on the resorptive activity of isolated osteoclasts. Bone 8:305–313

    Article  PubMed  CAS  Google Scholar 

  • Delmas PD, Bjarnason NH, Mitlak BH, Ravoux AC, Shah AS, Huster WJ, Draper M, Christiansen C(1997) Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med 337:1641–1647

    Article  PubMed  CAS  Google Scholar 

  • Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G(1996)Increased bone formation in osteocalcin-deficient mice. Nature 382:448–452

    Article  PubMed  CAS  Google Scholar 

  • Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL(1988)Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241 :84–86

    Article  PubMed  CAS  Google Scholar 

  • Everts V,Delaisse JM, Korper W, Niehof A, Vaes G, Beertsen W(1992) Degradation of collagen in the bone-resorbing compartment underlying the osteoclast involves both cysteine-proteinases and matrix metalloproteinases. J Cell Physiol 150:221–231

    Article  PubMed  CAS  Google Scholar 

  • Gray TK, Flynn TC, Gray KM, Nabell LM(1987)17j3-Estradiol acts directly on the clonal osteoblastic cell line UMR106. Proc Natl Acad Sci USA 84:6267–6271

    Article  PubMed  CAS  Google Scholar 

  • Holtrop ME, Raisz LG(1979)Comparison of the effects of 1,25-dihyroxy-cholecalciferol, prostaglandin E2, and osteoclast-activating factor with parathyroid hormone on the ultrastructure of osteoclasts in cultured long bones of fetal rats. Calcif Tissue Int 29:201–205

    Article  PubMed  CAS  Google Scholar 

  • Hou P, Ovejero MC, Sato T, Kumegawa M, Foged NT, Delaisse JM(1997) MMP-12, a proteinase that is indispensable for macrophage invasion, is highly expressed in osteoclasts (abstract). J Bone Miner Res 12:S417

    Article  Google Scholar 

  • Inaoka T, Bilbe G, Ishibashi 0, Tezuka K, Kumegawa M, Kokubo T(1995)Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone. Biochem Biophys Res Commun 206:89–96

    Article  PubMed  CAS  Google Scholar 

  • Jee WSS (1983) The skeletal tissues. In: Weiss L (ed) Histology, cell and tissue biology. Elsevier, New York, pp 200-255

    Google Scholar 

  • Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC(1992)Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257:88–91

    Article  PubMed  CAS  Google Scholar 

  • Kimble RB, Vannice JL, Bloedow DC, Thompson RC, Hopfer W, Kung VT, Brownfield C, Pacifici R(1994)Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats. J Clin Invest 93:1959–1967

    Article  PubMed  CAS  Google Scholar 

  • Kitazawa R, Kimble RB, Vannice JL, Kung VT, Pacifici R(1994)Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J Clin Invest 94:2397–2406

    Article  PubMed  CAS  Google Scholar 

  • Komm BS, Terpening CM, Benz DJ, Graeme KA, Gallegos A, Korc M, Greene GL, O’Malley BW, Haussler MR(1988)Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 241:81–-84

    Article  PubMed  CAS  Google Scholar 

  • Oursler MJ, Osdoby P, Pyfferoen J, Riggs BL, Spelsberg TC(1991)Avian osteoclasts as estrogen target cells. Proc Natl Acad Sci USA 88:6613–6617

    Article  PubMed  CAS  Google Scholar 

  • Oursler MJ, Pederson L, Pyfferoen J, Osdoby P, Fitzpatrick LA, Spelsberg TC(1993)Estrogen modulation of avian osteoclast lysosomal gene expression. Endocrinology 132:1373–1380

    Article  PubMed  CAS  Google Scholar 

  • Oursler MJ, Pederson L, Fitzpatrick LA, Riggs BL, Spelsberg TC(1994)Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells. Proc N atl Acad Sci USA 88:6613–6617

    Google Scholar 

  • Parfitt AM (1979) Quantum concept of bone remodeling and turnover: implications for the pathogenesis of osteoporosis. Calcif Tissue Int 28:1–5

    Article  PubMed  CAS  Google Scholar 

  • LPederson, MKremer, NTFoged, BWinding, LAFitzpatrick, MJOursler1997 Evidence of a correlation of estrogen receptor level and avian osteoclast estrogen responsiveness. J Bon Mnr Rs 12:742–752

    Google Scholar 

  • Reponen P, Sahlberg C, Munaut C, Thesleff I, Tryggvason K(1994)High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development. J Cell Bioi 124:1091–1102

    Article  CAS  Google Scholar 

  • Roodman GD(1996)Advances in bone biology: the osteoclast. Endocr Rev 17:308–332

    PubMed  CAS  Google Scholar 

  • Sato T, Ovejero M, Hou P, Heegard AM, Kumegawa M, Foged N, Delaisse JM(1997)Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts. J Cell Sci 110:589–596

    PubMed  CAS  Google Scholar 

  • Termine JD, Robey PG (1996)Anatomy and ultrastructure of bone. In: Favus, MJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 3rd edn. Lippencott-Raven, Philadelphia, pp 24–-28

    Google Scholar 

  • Tezuka K-I, Tezuka Y, Maejima A, Sato T, Nemoto K, Kamioka H, Hakeda Y, Kumegawa M(1994)Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts. J BioI Chern 269:1106–1109

    CAS  Google Scholar 

  • Votta BJ, Levy MA, Badger A, Bradbeer J, Dodds RA, James IE, Thompson S, Bossard MJ, Carr T, Connor JR, Tomaszek TA, Szewczuk L, Drake FH, Veber DF, Gowen M(1997)Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo.J Bone Miner Res 12:1396–1406

    Article  PubMed  CAS  Google Scholar 

  • Xu T, Longneck G, Fisher L, Heegaard AM, Satomura K, Bianco G, Sommer B, Kulkarni A, Robey PG, Young MF (1997)Mice with targeted disruption of the biglycan gene exhibit decreased bone density and increased expression of decorin (abstract). J Bone Miner Res 12:S125

    Google Scholar 

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© 1999 Springer-Verlag Berlin Heidelberg

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Winding, B., JØrgensen, H., Christiansen, C. (1999). Bone. In: Estrogens and Antiestrogens II. Handbook of Experimental Pharmacology, vol 135 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60107-1_6

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  • DOI: https://doi.org/10.1007/978-3-642-60107-1_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64261-6

  • Online ISBN: 978-3-642-60107-1

  • eBook Packages: Springer Book Archive

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