Abstract
Estrogen therapy is indicated whenever estrogen deficiency is at hand. Such deficiency could be either general or local. The major indications for systemic therapy would be climacteric symptoms, such as sweats and hot flushes etc., and for inducing or maintaining female sex characteristics in primary and secondary amenorrhoea. However, estrogen mono therapy is seldom used for lengthier periods due to its stimulatory effect on the endometrium. Prolonged estrogen treatment may lead to endometrial cancer, but much more often to various types of bleeding disorders. A progestogen is therefore usually added when administering estrogen to women with intact uteri. In this chapter, a number of clinical conditions will be mentioned, in which estrogen treatment has been shown to be useful. However, it should be remembered that, in most cases, a progestogen co-medication is necessary in women with intact uteri.
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Samsioe, G. (1999). Gynaecological Disorders. In: Estrogens and Antiestrogens II. Handbook of Experimental Pharmacology, vol 135 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60107-1_20
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DOI: https://doi.org/10.1007/978-3-642-60107-1_20
Publisher Name: Springer, Berlin, Heidelberg
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