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Measurement of Anticonvulsants and Their Metabolites in Biological Fluids

  • Chapter
Antiepileptic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 138))

Abstract

There seems to be a greater volume of literature dealing with the assay of antiepileptic drugs and their metabolites than with the assay of almost any other class of drugs. Many factors have contributed to this situation, including (1) the older antiepileptic drugs have been studied over a long period, (2) several antiepileptic drugs have unusual and interesting disposition characteristics, which have warranted extensive study, (3) antiepileptic drugs are probably the drug class to which therapeutic drug monitoring (TDM) is most commonly applied, and (4) there are a large number of antiepileptic drugs in clinical use or under development. There is a great diversity of analytical methods, and to a large extent the choice of method is governed by the application to which the method will be put. It is often the case that a method which is suitable for therapeutic drug monitoring will not meet the requirements of clinical pharmacokinetic or metabolic studies, while methods which meet these latter requirements may be inappropriate in terms of cost, speed or convenience in the therapeutic drug monitoring laboratory. While it is not possible in the space available to give a comprehensive survey of all methods for all drugs, we have attempted to provide a contemporary outline of the most commonly used methods, to indicate their attributes, limitations and areas of applicability, and to provide references in which further information may be located.

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Authors
  1. W. D. Hooper
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  2. L. P. Johnson
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Editors and Affiliations

  1. Departments of Medicine, Royal Brisbane Hospital, University of Queensland, Clinical Sciences Building, Herston, Qld., 4029, Australia

    Mervyn J. Eadie AO, MD, PhD

  2. Australian Centre for Clinical Neuropharmacology, St. Vincent’s Hospital, Fitzroy, Victoria, 3065, Australia

    Frank J. E. Vajda M.D.

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Hooper, W.D., Johnson, L.P. (1999). Measurement of Anticonvulsants and Their Metabolites in Biological Fluids. In: Eadie, M.J., Vajda, F.J.E. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 138. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60072-2_7

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  • DOI: https://doi.org/10.1007/978-3-642-60072-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64244-9

  • Online ISBN: 978-3-642-60072-2

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