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Lamotrigine

  • Chapter
Antiepileptic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 138))

Abstract

In 1966, Reynolds et al. proposed that the antiepileptic actions of the then available antiepileptic drugs might be partially mediated through their antifolate effects. This idea gained further credence when it was discovered that folate and its derivatives were proconvulsant when given in large doses systemically or applied directly onto the cortex (Fisher 1989). The hypothesis resulted in the development of a number of antifolate agents and their testing in animal models of epilepsy. These experiments revealed a poor correlation between antifolate properties and anticonvulsant effects, but a group of phenyltriazine compounds, which had weak antifolate properties, proved to be potent anticonvulsants. Lamotrigine was developed from these compounds, though neither short-term nor chronic lamotrigine therapy appears to be associated with significant changes in serum or red cell folate concentrations (Sander and Patsalos 1992).

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Authors
  1. M. C. Walker
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  2. J. W. A. S. Sander
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Editor information

Editors and Affiliations

  1. Departments of Medicine, Royal Brisbane Hospital, University of Queensland, Clinical Sciences Building, Herston, Qld., 4029, Australia

    Mervyn J. Eadie AO, MD, PhD

  2. Australian Centre for Clinical Neuropharmacology, St. Vincent’s Hospital, Fitzroy, Victoria, 3065, Australia

    Frank J. E. Vajda M.D.

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© 1999 Springer-Verlag Berlin Heidelberg

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Walker, M.C., Sander, J.W.A.S. (1999). Lamotrigine. In: Eadie, M.J., Vajda, F.J.E. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 138. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60072-2_12

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  • DOI: https://doi.org/10.1007/978-3-642-60072-2_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64244-9

  • Online ISBN: 978-3-642-60072-2

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