Skip to main content

Mechanisms in Cellular Injury

  • Chapter
  • 84 Accesses

Abstract

The exact mechanisms underlying the initiation and progression of acute pancreatitis remain unclear. Current research is concentrated on acinar cell events and the systemic complications of the early phase of acute pancreatitis (multiorgan failure, vascular leakage, excessive leukocyte activation, ARDS) (Rinderknecht et al. 1988).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Ammann RW, Heitz PhU, Klöppel G (1996) Course of alcoholic chronic pancreatitis: a prospective clinicomorphological long-term study. Gastroenterology 111:224–231

    Article  PubMed  CAS  Google Scholar 

  • Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS (1998) Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43:128–133

    Article  PubMed  CAS  Google Scholar 

  • Bachern MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grunert A, Adler G (1998) Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115:421–432

    Article  Google Scholar 

  • Büchler M, Malfertheiner P, Uhl W (1993) Gabexate mesilate in human acute pancreatitis. Gastroenterology 104:1165–1170

    PubMed  Google Scholar 

  • Cavallini G, Tittobello A, Frulloni L, Masci E, Mariani A, Di Francesco V, and the Italian Group (1996) Gabexate in digestive endoscopy. N Engl J Med 335:919–923

    Article  PubMed  CAS  Google Scholar 

  • Denham W, Yang J, Fink G, Norman J (1997) Gene targeting demonstrates additive detrimental effects of IL-1 and TNF during pancreatitis. Gastroenterology 113:1741–1746

    Article  PubMed  CAS  Google Scholar 

  • Denham W, Denham D, Yang J, Carter G, MacKay S, Moldawer LL, Carey LC, Norman J (1998 a) Transient human gene therapy: a novel cytokine regulatory strategy for experimental pancreatitis. Ann Surg 227:812–820

    Article  PubMed  CAS  Google Scholar 

  • Denham W, Yang J, Fink G, Denham D, Carter G, Bowers V, Norman J (1998b) TNF but not IL-1 decreases pancreatic acinar cell survival without affecting exocrine function: a study in the perfused human pancreas. J Surg Res 74:3–7

    Article  PubMed  CAS  Google Scholar 

  • Hanck C, Hartmann A, Rossol S, Singer MV (1998) Cytokine gene expression in peripheral blood mononuclear cells suggests a systemic inflammatory response in alcoholic chronic pancreatitis. Abstract no 48, 8th meeting of the International Association of Pancreatology, Tokyo. Int J Pancreatol 23:224

    Google Scholar 

  • Hofheinz H, Richter A, Nebe Th, Tsuji Y, Schmoll M, Fiedler F (1997) Immunomodulation with interferon-gamma in acute pancreatitis in rats. In: The immune consequences of trauma, shock and sepsis. Monduzzi, Bologna, pp 483–487

    Google Scholar 

  • Klar E, Foitzik T, Buhr H, Messmer K, Herfarth C (1993) Isovolemic hemodilution with dextran 60 as treatment of pancreatic ischemia in acute pancreatitis. Clinical practicability of an experimental concept. Ann Surg 217:369–374

    Article  PubMed  CAS  Google Scholar 

  • Kusske AM, Rongione AJ, Ashley SW, McFadden DW, Reber HA (1996) Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice. Surgery 120:284–288

    Article  PubMed  CAS  Google Scholar 

  • McKay C, Curran FJ, Sharpies CE, Young CA, Baxter JN, Imrie CW (1996) The use of lexipafant in the treatment of acute pancreatitis. Adv Exp Med Biol 416:365–370

    PubMed  CAS  Google Scholar 

  • Osman MO, Jacobsen NO, Kristensen JU, Deleeuran B, Gesser B, Larsen CG, Jensen SL (1998) IT 9302, a synthetic interleukin-10 agonist, diminishes acute lung injury in rabbits with acute necrotizing pancreatitis. Surgery 124:584–592

    Article  PubMed  CAS  Google Scholar 

  • Riesle E, Friess H, Zhao L, Wagner M, Uhl W, Baczako K (1997) Increased expression of transforming growth factor b after acute oedematous pancreatitis in rats suggests a role in pancreatic repair. Gut 40:73–79

    PubMed  CAS  Google Scholar 

  • Rinderknecht H (1988) Fatal pancreatitis, a consequence of excessive leucocyte stimulation? Int J Pancreatol 3:105–112

    PubMed  CAS  Google Scholar 

  • Todd KE, Lewis MP, Gloor B, Lane HS, Ashley SW, Reber HA (1997) An ETa/ETb endothelin antagonist ameliorates systemic inflammation in a murine model of acute hemorrhagic pancreatitis. Surgery 122:443–449

    Article  PubMed  CAS  Google Scholar 

  • Van Laethem JL, Marchant A, Delvaux A, Goldman M, Robberecht P, Velu T, Devière J (1995) Interleukin 10 prevents necrosis in murine experimental acute pancreatitis. Gastroenterology 108:1917–1922

    Article  PubMed  Google Scholar 

  • Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK Jr, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD (1996) Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 14:141–145

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hanck, C., Singer, M.V. (1999). Mechanisms in Cellular Injury. In: Pancreatic Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60068-5_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60068-5_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65357-8

  • Online ISBN: 978-3-642-60068-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics