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Lessons Learned about Pancreatitis and Pancreatic Cancer from Epidemiological Studies

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Book cover Pancreatic Disease

Abstract

Acute pancreatitis, chronic pancreatitis, and pancreatic cancer are the three acquired pancreatic disorders most commonly encountered by physicians and surgeons. In addition, about 90% of persons with cystic fibrosis, an autosomal regressive disorder, suffer from severe pancreatic insufficiency. The etiology of these diseases is becoming clearer, and we are beginning to understand the interrelationships between all of these serious disorders. In this chapter we will review current thinking about benign and malignant exocrine pancreatic disease, discuss risk factors, and consider what is known about the natural history of these diseases.

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References

  1. Ammann RW, Abovbiantz A, Largiader F, Schueler G (1984) Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology 86:820–828

    PubMed  CAS  Google Scholar 

  2. Ammann RW, Heitz PU, Kloppel G (1996) Course of alcoholic chronic pancreatitis: a prospective clinicomorphological long-term study Gastroenterology 111:224–231

    Article  PubMed  CAS  Google Scholar 

  3. Baghurst PA, McMichael AJ, Slavotinek AH, Baghurst KI, Boyle P, Walker AM (1991) A case-control study of diet and cancer of the pancreas. Am J Epidemiol 134:167–179

    PubMed  CAS  Google Scholar 

  4. Boyle P, Hsieh CC, Maisonneuve P, La Vecchia C, Macfarlane GJ, Walker AM, et al (1989) Epidemiology of pancreas cancer (1988). Int J Pancreatol 5:327–346

    PubMed  CAS  Google Scholar 

  5. Bueno de Mesquita HB, Maisonneuve P, Moerman CJ, Runia S, Boyle P (1991) Lifetime history of smoking and exocrine carcinoma of the pancreas: a population-based case-control study in The Netherlands. Int J Cancer 49:816–822

    Article  PubMed  CAS  Google Scholar 

  6. Bueno de Mesquita HB, Maisonneuve P, Runia S, Moerman CJ (1991) Intake of foods and nutrients and cancer of the exocrine pancreas: a population-based case-control study in The Netherlands. Int J Cancer 48:540–549

    Article  PubMed  CAS  Google Scholar 

  7. Caraballo RS, Giovino GA, Pechacek TF, et al (1998) Racial and ethnic differences in serum cotinine levels of cigarette smokers. Third national health and nutrition examination survey, 1988–1991. JAMA 280:135–139

    Article  PubMed  CAS  Google Scholar 

  8. Chari ST, Mohan V, Pitchumoni CS, Viswanathan M, Madanagopalan N, Lowenfels AB (1994) Risk of pancreatic carcinoma in tropical calcifying pancreatitis: an epidemiologic study. Pancreas 9:62–66

    Article  PubMed  CAS  Google Scholar 

  9. Cohn JA, Friedman KJ, Silverman LM, et al (1998) Abnormalities of the CFTR gene predispose to idiopathic chronic pancreatitis. Gastroenterology 114:449 Abstr

    Article  Google Scholar 

  10. Copenhagen Pancreatitis Study Group (1981) Copenhagen Pancreatitis Study. An interim report from a prospective epidemiological multicentre study. Scand J Gastroenterol 16:305–312

    Article  Google Scholar 

  11. Diehl AK, Holleman DRJ, Chapman JB, Schwesinger WH, Kurtin WE (1997) Gallstone size and risk of pancreatitis. Arch Intern Med 157:1674–1678

    Article  PubMed  CAS  Google Scholar 

  12. Doll R, Peto R, Wheatley K, Gray R, Sutherland I (1994) Mortality in relation to smoking: 40 years’ observations on male British doctors. Br Med J 309:901–911

    CAS  Google Scholar 

  13. Falk RT, Pickle LW, Fontham ET, Correa P, Fraumeni JFJ (1988) Life-style risk factors for pancreatic cancer in Louisiana: a case-control study. Am J Epidemiol 128:324–336

    PubMed  CAS  Google Scholar 

  14. Ghadirian P, Simard A, Baillargeon J, Maisonneuve P, Boyle P (1991) Nutritional factors and pancreatic cancer in the francophone community in Montreal, Canada. Int J Cancer 47:1–6

    Article  PubMed  CAS  Google Scholar 

  15. Ghadirian P, Simard A, Baillargeon J (1993) A population-based case-control study of cancer of the bile ducts and gallbladder in Quebec, Canada. Rev Epidemiol Sante Publ 41:107–112

    CAS  Google Scholar 

  16. Gold EB, Gordis L, Diener MD, et al (1985) Diet and other risk factors for cancer of the pancreas. Cancer 55:460–467

    Article  PubMed  CAS  Google Scholar 

  17. Houssin D, Castaing D, Lemoine J, Bismuth H (1983) Microlithiasis of the gallbladder. Surg Gynecol Obstet 157:20–24

    PubMed  CAS  Google Scholar 

  18. Howe GR, Jain M, Burch JD, Miller AB (1991) Cigarette smoking and cancer of the pancreas: evidence from a population-based case-control study in Toronto, Canada. Int J Cancer 47:323–328

    Article  PubMed  CAS  Google Scholar 

  19. Kalapothaki V, Tzonou A, Hsieh CC, Toupadaki N, Karakatsani A, Trichopoulos D (1993) Tobacco, ethanol, coffee, pancreatitis, diabetes mellitus, and cholelithiasis as risk factors for pancreatic carcinoma. Cancer Causes Control 4:375–382

    Article  PubMed  CAS  Google Scholar 

  20. Lankisch PG, Assmus D, Pflichthofer D, Maisonneuve P, Lowenfels AB (1998) The burden of pancreatic disease in a well-defined population. Gastroenterology 114:A24 Abstr

    Google Scholar 

  21. La Vecchia C, Negri E, D’Avanzo B, Ferraroni M, Gramenzi A, Savoldelli R, et al (1990) Medical history, diet and pancreatic cancer. Oncology 47:463–466

    Article  PubMed  Google Scholar 

  22. Lowenfels AB, Zwemer FL, Jhangiani S, Pitchumoni CS (1987) Pancreatitis in a native American Indian population. Pancreas 2:694–697

    Article  PubMed  CAS  Google Scholar 

  23. Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, et al (1993) Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 328:1433–1437

    Article  PubMed  CAS  Google Scholar 

  24. Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LKJ, Perrault J, et al (1997) Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst 89:442–446

    Article  PubMed  CAS  Google Scholar 

  25. Madeira I, Pessione F, Malka D, Hammel P, Ruszniewski P, Bernades P (1998) The risk of pancreatic adenocarcinoma in patients with chronic pancreatitis: myth or reality? Gastroenterology 114:A481 Abstr

    Article  Google Scholar 

  26. Neglia JP, FitzSimmons SC, Maisonneuve P, Schoni MH, Schoni-Affolter F, Corey M, et al (1995) The risk of cancer among patients with cystic fibrosis. N Engl J Med 332

    Google Scholar 

  27. Negri E, La Vecchia C, Franceschi S, D’Avanzo B, Parazzini F (1991) Vegetable and fruit consumption and cancer risk. Int J Cancer 48:350–354

    Article  PubMed  CAS  Google Scholar 

  28. Parkin DM, Muir C, Whelan SL, et al (1992) Cancer incidence in five continents. IARC Scientific Publications No. 120. IARC Sci Publ 1–1033

    Google Scholar 

  29. Preston-Martin S, Pike MC, Ross RK, Jones PA, Henderson BE (1990) Increased cell division as a cause of human cancer. Cancer Res 50:7415–7421

    PubMed  CAS  Google Scholar 

  30. Richie JP, Carmella SG, Muscat JE, Scott DG, Akerkar SA, Hecht SS (1997) Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methynitrosamino)-l-(3-pyridyl)-l-butanone in black and white smokers. Cancer Epidemiol Biomarkers Prev 6:783–790

    PubMed  CAS  Google Scholar 

  31. Talamini G, Bassi C, Falconi M, Frulloni L, Di Francesco V, Vaona B et al. (1996) Cigarette smoking: an independent risk factor in alcoholic pancreatitis. Pancreas 12:131–137

    Article  PubMed  CAS  Google Scholar 

  32. Yen S, Hsieh C, MacMahon B (1982) Consumption of alcohol and tobacco and other risk factors for pancreatitis. Am J Epidemiol 116:407–414

    PubMed  CAS  Google Scholar 

  33. Zatonski W, Przewozniak K, Howe GR, Maisonneuve P, Walker AM, Boyle P (1991) Nutritional factors and pancreatic cancer: a case-control study from south-west Poland. Int J Cancer 48:390–394

    Article  PubMed  CAS  Google Scholar 

  34. Zatonski WA, Boyle P, Przewozniak K, Maisonneuve P, Drosik K, Walker AM (1993) Cigarette smoking, alcohol, tea and coffee consumption and pancreas cancer risk: a case-control study from Opole, Poland. Int J Cancer 53:601–607

    Article  PubMed  CAS  Google Scholar 

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© 1999 Springer-Verlag Berlin Heidelberg

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Lowenfels, A.B., Maisonneuve, P., Lankisch, P.G. (1999). Lessons Learned about Pancreatitis and Pancreatic Cancer from Epidemiological Studies. In: Pancreatic Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60068-5_24

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  • DOI: https://doi.org/10.1007/978-3-642-60068-5_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65357-8

  • Online ISBN: 978-3-642-60068-5

  • eBook Packages: Springer Book Archive

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