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Animal Models of Helicobacter Gastritis

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Gastroduodenal Disease and Helicobacter pylori

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 241))

Abstract

Development of animal models of Helicobacter gastritis has been a priority since Marshall and Warren first identified the association between gastritis, peptic ulcer, and infection with Helicobacter pylori (Marshall and Warren 1984). In the approximately 10 years since the introduction of the first animal model (the germ-free piglet; Krakowka et al. 1987; Lambert et al. 1987), a bewildering array of new animal models has been introduced, involving host species as disparate as monkeys and mice, and bacterial species isolated from primates, carnivores, and pigs as well as humans. Investigators have used different methods to induce Helicobacter-associated disease in animals, and have examined aspects of Helicobacter-associated disease ranging from mechanisms of bacterial colonization and induction of gastritis to carcinogenic potential. The result is a large body of sometimes conflicting information regarding animal models, their uses, and their relevance to the pathogenesis of human disease associated with H. pylori.

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  1. Department of Veterinary Biosciences, Ohio State University, 1925 Coffey Rd, Columbus, OH, 43210, USA

    K. A. Eaton

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  1. Medical Service (111), Central Texas Veterans Health Care System, Texas A&M University, College of Medicine, 1901 S. First Street, Temple, TX, 76504, USA

    T. Ulf Westblom M.D. (Chief) (Chief)

  2. Department of Pediatrics, Division of Pediatric Gastroenterology, Rainbow Babies and Children Hospital, Case Western Reserve University, 2074 Abington Road, Cleveland, OH, 44106, USA

    Steven J. Czinn M.D.

  3. Institute of Pathology, Case Western Reserve University, Biomedical Research Building, Rm. 919, 10900 Euclid Avenue, Cleveland, OH, 44106-4943, USA

    John G. Nedrud Ph.D. (Associate Professor) (Associate Professor)

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Eaton, K.A. (1999). Animal Models of Helicobacter Gastritis. In: Westblom, T.U., Czinn, S.J., Nedrud, J.G. (eds) Gastroduodenal Disease and Helicobacter pylori . Current Topics in Microbiology and Immunology, vol 241. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60013-5_8

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