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Gastric Cancer and Lymphoma

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Gastroduodenal Disease and Helicobacter pylori

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 241))

Abstract

In 1983 Warren and Marshall discovered a spiral urease-producing organism in the human stomach, later classified as Helicobactor pylori. The prevalence of H. pylori infection varies worldwide, but higher infection rates are seen in developing countries compared with developed ones (Megraud et al. 1989; Dooley et al. 1989; Mitchell et al. 1988; Anonymous 1990). It may be the most common infection worldwide. In developed countries infection with H. pylori occurs in more than 50% of adults, while developing countries have infection rates reaching 90% (Hopkins and Morris 1994). H. pylori are gram-negative microaerophilic spiral bacteria that can colonize the gastric mucosa for years (Morris et al. 1991), and in most cases they probably persist for life. H. pylori has been shown to be strongly associated with peptic ulcer disease, and antibiotic therapy to eradicate this organism is an important treatment for duodenal and gastric ulcers (Anonymous 1994). H. pylori infection is now considered a risk factor for gastric adenocarcinoma and for primary gastric non-Hodgkin’s lymphoma.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Hematology-Oncology, Texas A&M University College of Medicine, and Central Texas Veterans Health Care System, Medical Service (111-H), 1901 S. First Street, Temple, TX, 76504, USA

    P. Mukhopadhyay

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  1. P. Mukhopadhyay
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Editors and Affiliations

  1. Medical Service (111), Central Texas Veterans Health Care System, Texas A&M University, College of Medicine, 1901 S. First Street, Temple, TX, 76504, USA

    T. Ulf Westblom M.D. (Chief) (Chief)

  2. Department of Pediatrics, Division of Pediatric Gastroenterology, Rainbow Babies and Children Hospital, Case Western Reserve University, 2074 Abington Road, Cleveland, OH, 44106, USA

    Steven J. Czinn M.D.

  3. Institute of Pathology, Case Western Reserve University, Biomedical Research Building, Rm. 919, 10900 Euclid Avenue, Cleveland, OH, 44106-4943, USA

    John G. Nedrud Ph.D. (Associate Professor) (Associate Professor)

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Mukhopadhyay, P. (1999). Gastric Cancer and Lymphoma. In: Westblom, T.U., Czinn, S.J., Nedrud, J.G. (eds) Gastroduodenal Disease and Helicobacter pylori . Current Topics in Microbiology and Immunology, vol 241. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60013-5_5

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  • DOI: https://doi.org/10.1007/978-3-642-60013-5_5

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