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Gastroduodenal Disease and Helicobacter pylori pp 181–213Cite as

Host Response and Vaccine Development to Helicobacter pylori Infection

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 241))

Abstract

Infection of humans by Helicobacter pylori can have various outcomes (Fig. 1). In virtually all cases a state of chronic/active gastritis results from an infection by H. pylori, but whether this gastritis progresses to more severe disease states such as duodenal or gastric ulcers or serves as a precursor to gastric cancer appears to be Influenced by both the host response and bacterial virulence determinants. Bacterial virulence factors have been reviewed elsewhere in this volume (“Mechanisms of Helicobacter pylori Infection: Bacterial Factors”); this chapter focuses on the host response to Helicobacter infections in the context of these virulence factors.

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  1. Departments of Pathology and Pediatrics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA

    T. G. Blanchard, S. J. Czinn & J. G. Nedrud

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  2. S. J. Czinn
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  3. J. G. Nedrud
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  1. Medical Service (111), Central Texas Veterans Health Care System, Texas A&M University, College of Medicine, 1901 S. First Street, Temple, TX, 76504, USA

    T. Ulf Westblom M.D. (Chief) (Chief)

  2. Department of Pediatrics, Division of Pediatric Gastroenterology, Rainbow Babies and Children Hospital, Case Western Reserve University, 2074 Abington Road, Cleveland, OH, 44106, USA

    Steven J. Czinn M.D.

  3. Institute of Pathology, Case Western Reserve University, Biomedical Research Building, Rm. 919, 10900 Euclid Avenue, Cleveland, OH, 44106-4943, USA

    John G. Nedrud Ph.D. (Associate Professor) (Associate Professor)

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Blanchard, T.G., Czinn, S.J., Nedrud, J.G. (1999). Host Response and Vaccine Development to Helicobacter pylori Infection. In: Westblom, T.U., Czinn, S.J., Nedrud, J.G. (eds) Gastroduodenal Disease and Helicobacter pylori . Current Topics in Microbiology and Immunology, vol 241. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60013-5_10

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