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SB 209763: A Humanized Monoclonal Antibody for the Prophylaxis and Treatment of Respiratory Syncytial Virus Infection

  • T. G. Porter
  • S. G. Griego
  • T. K. Hart
  • D. E. Everitt
  • S. B. Dillon
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 137)

Abstract

Respiratory syncytial virus (RSV) is a major and highly contagious respiratory pathogen that most people are exposed to within the first year or two of life. It is the dominant cause of severe lower respiratory-tract disease (bronchiolitis and pneumonia) in infants and young children, leading to approximately 100,000 hospitalizations each year in the United States alone (HEILMAN 1990). There are two major antigenically distinct subgroups of RSV, A and B, which can circulate simultaneously and are responsible for predictable winter epidemics each year. In adults and older children, symptoms resemble the common cold and are normally mild and confined to the upper respiratory tract. However, in infants and young children, RSV infection often progresses to the lower respiratory tract, where it can lead to serious respiratory complications requiring hospitalization and, in rare cases, may even result in death. Infants with underlying cardiac or pulmonary disease, and some premature/low-birth-weight infants are at considerably higher risk of more severe disease and increased mortality from RSV infection, and are candidates for prophylactic intervention during the winter months. Although not well studied, immunosuppressed adult populations (the elderly, organ-transplant recipients) are also prone to life-threatening infections.

Keywords

Respiratory Syncytial Virus Respiratory Syncytial Virus Infection Human Respiratory Syncytial Virus Respiratory Syncytial Virus Season Respiratory Syncytial Virus Neutralize Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • T. G. Porter
  • S. G. Griego
  • T. K. Hart
  • D. E. Everitt
  • S. B. Dillon

There are no affiliations available

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