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Targeted Toxin Hybrid Proteins

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Novel Therapeutics from Modern Biotechnology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 137))

Abstract

The goal of targeted therapy is to kill cells bearing specific receptors. This is in contradistinction to cytotoxic chemotherapy, which depends on biochemical differences between normal and target cells. Many types of malignant cells, including those resistant to cytotoxic chemotherapy, display unique proteins on the cell surface, making such cells potentially sensitive to targeted therapy. Unlike small chemotherapeutic agents, which enter the cell by passing though the membrane, targeted therapy must enter through the specific receptors or antigens on the cell surface. Because such sites number only thousands per cell, the targeted agent must be extremely potent. Typically, protein toxins are used since they kill cells by catalytic mechanisms. In fact, it has been shown with both bacterial and plant toxins that only one molecule in the cytoplasm of cells is sufficient to kill the cell (CARRASCO et al. 1975; YAMAIZUMI et al. 1978; WILLINGHAM, FITZGERALD and PASTAN unpublished data).

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  1. R. J. Kreitman
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  2. I. Pastan
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Editors and Affiliations

  1. Parke-Davis Pharmaceutical Research, 2800 Plymouth Road, 48105, Ann Arbor, MI, USA

    Dale L. Oxender Ph.D. Cell Biology  & Leonard E. Post Ph.D. (Vice President, Discovery Research) &  (Vice President, Discovery Research)

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Kreitman, R.J., Pastan, I. (1999). Targeted Toxin Hybrid Proteins. In: Oxender, D.L., Post, L.E. (eds) Novel Therapeutics from Modern Biotechnology. Handbook of Experimental Pharmacology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59990-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-59990-3_5

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