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Novel Therapeutics from Modern Biotechnology pp 59–88Cite as

Strategies for Dealing With the Immunogenicity of Therapeutic Proteins

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 137))

Abstract

As proteins and peptides (hereinafter referred to collectively as “proteins”) are major components of biological processes, it is logical to assume that their potential for use as therapeutics would be extremely high. However, the recognizable need for a defense system has implications for the administration of protein-based pharmaceuticals (Table 1). Minor differences in the primary structure of proteins—even as little as one amino acid from the human form of the protein—have been shown to be sufficient for immune system recognition.

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  1. M. L. Nucci
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  2. R. G. L. Shorr
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  3. A. Abuchowski
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  1. Parke-Davis Pharmaceutical Research, 2800 Plymouth Road, 48105, Ann Arbor, MI, USA

    Dale L. Oxender Ph.D. Cell Biology  & Leonard E. Post Ph.D. (Vice President, Discovery Research) &  (Vice President, Discovery Research)

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Nucci, M.L., Shorr, R.G.L., Abuchowski, A. (1999). Strategies for Dealing With the Immunogenicity of Therapeutic Proteins. In: Oxender, D.L., Post, L.E. (eds) Novel Therapeutics from Modern Biotechnology. Handbook of Experimental Pharmacology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59990-3_4

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