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Strategies for Dealing With the Immunogenicity of Therapeutic Proteins

  • M. L. Nucci
  • R. G. L. Shorr
  • A. Abuchowski
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 137)

Abstract

As proteins and peptides (hereinafter referred to collectively as “proteins”) are major components of biological processes, it is logical to assume that their potential for use as therapeutics would be extremely high. However, the recognizable need for a defense system has implications for the administration of protein-based pharmaceuticals (Table 1). Minor differences in the primary structure of proteins—even as little as one amino acid from the human form of the protein—have been shown to be sufficient for immune system recognition.

Keywords

Human Insulin Therapeutic Protein Cutaneous Leishmaniasis Protein Drug Bispecific Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • M. L. Nucci
  • R. G. L. Shorr
  • A. Abuchowski

There are no affiliations available

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