Skip to main content

Die Bedeutung von β-Catenin bei der Entstehung kolorektaler Karzinome

  • Chapter
Ökosystem Darm VIII
  • 47 Accesses

Zusammenfassung

Das kolorektale Karzinom (KRK) ist mit einem Anteil von 10–16% eine der häufigsten malignen Erkrankungen weltweit. Eine kurative Therapie ist auch heute noch ausschließlich durch die radikale chirurgische Resektion möglich, deren Erfolg weitgehend vom Krankheitsstadium abhängt [2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Behrens J, Kries JP von, Kuhl M et al. (1996) Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382:638.

    Article  PubMed  CAS  Google Scholar 

  • Boese-Landgraf J (1998) Epidemiologie, Vorstufen und Pathogenese des kolorektalen Karzinoms. Onkologe 4:2.

    Article  Google Scholar 

  • D’Abaco G, Whitehead R, Brugess A (1996) Synergy between APCmin and an activated ras mutation is sufficiënt to induce colon carcinomas. Mol Cell Biol 16:884.

    PubMed  Google Scholar 

  • Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759.

    Article  PubMed  CAS  Google Scholar 

  • Günther K, Brabletz T, Kraus C et al. (1998) Predictive value of nuclear beta-Catenin expression for the occurence of distant metastases in rectal cancer. Dis Col Rect (in press).

    Google Scholar 

  • Hahn S et al. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271:350.

    Article  PubMed  CAS  Google Scholar 

  • Iravani S, Mao W, Fu L et al. (1998) Elevated c-Src protein expression is an early event in colonic neoplasia. Lab Invest 78:365 Catenin signaling during embryogenesis in the mouse. Mol Cell Biol 18:1248.

    PubMed  CAS  Google Scholar 

  • Korinek V, Barker N, Morin PJ et al. (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma [see comments]. Science 275:1784.

    Article  PubMed  CAS  Google Scholar 

  • Korinek V , Barker N, Willert K et al. (1998) Two members of the TCF family implicated in the WNT/beta-Catenin signaling during embryogenesis in the mouse. Mol Cell Biol 18:1248

    PubMed  CAS  Google Scholar 

  • Molenaar M, van de Weterin M, Oosterwege M et al. (1996) XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell 86:39.

    Article  Google Scholar 

  • Morin PJ, Sparks AB, Korinek V et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC [see comments]. Science 275:1787.

    Article  PubMed  CAS  Google Scholar 

  • Peifer M (1997) Beta-catenin as oncogene: the smoking gun [comment]. Science 275:1752.

    Article  PubMed  CAS  Google Scholar 

  • Polakis P (1997) The adenomatous polyposis coli (APC) tumor suppressor. Biochim Biophys Acta 1332:F127.

    PubMed  CAS  Google Scholar 

  • Ramsay R, Thompson M, Hayman J et al. (1992) Myb expression is higher in malignant human colonic carcinoma and premalignant adenomatous polyps than in normal mucosa. Cell Growth Differ 3:723.

    PubMed  CAS  Google Scholar 

  • Rubinfeld B, Soza B, Albert I et al. (1993) Association of the APC gene product with beta-catenin. Science 262:1731.

    Article  PubMed  CAS  Google Scholar 

  • Su LK, Vogelstein B, Kinzier KW (1993) Association of the APC tumor suppressor protein with catenins. Science 262:1734.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Brabletz, T., Jung, A., Kirchner, T. (1999). Die Bedeutung von β-Catenin bei der Entstehung kolorektaler Karzinome. In: Kirchner, T., Lembcke, B., Kist, M. (eds) Ökosystem Darm VIII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59963-7_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59963-7_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64837-6

  • Online ISBN: 978-3-642-59963-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics