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Ökosystem Darm VIII pp 257–264Cite as

Periphere und zentrale Komponenten gastrointestinaler Sensibilitätsstörungen

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Zusammenfassung

Zahlreiche Untersuchungen in den letzten Jahren haben überzeugende Hinweise dafür erbracht, daß bei funktionellen gastrointestinalen Erkrankungen, bei denen durch konventionelle diagnostische Maßnahmen keine strukturellen oder biochemischen Alterationen nachweisbar sind, die geklagten Symptome die Folge einer gestörten Interaktion zwischen dem Zentralnervensystem (ZNS) und dem Gastrointestinaltrakt sind (zur Übersicht [14, 18]). Human- und tierexperimentelle Studien weisen darauf hin, daß dieser Störung primär veränderte afferent-sensorische Prozesse und/oder primär veränderte efferente Mechanismen der „Brain-gut“-Interaktion zu Grunde liegen können. Das klassische Beispiel für auch klinisch relevante Veränderungen in der efferenten zentralnervösen Kontrolle des Verdauungstraktes sind die gut charakterisierten Effekte von Stress auf die gastrointestinale (GI) Motilität [4,12,32].

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Authors
  1. H. Mönnikes
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Editors and Affiliations

  1. Pathologisch-Anatomisches Institut, Universität Erlangen-Nürnberg, Krankenhausstraße 8-10, D-91054, Erlangen, Germany

    Thomas Kirchner

  2. Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    Bernhard Lembcke

  3. Institut für Medizinische Mikrobiologie und Hygiene, Hermann-Herder-Straße 11, D-79104, Freiburg, Germany

    Manfred Kist

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© 1999 Springer-Verlag Berlin Heidelberg

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Mönnikes, H. (1999). Periphere und zentrale Komponenten gastrointestinaler Sensibilitätsstörungen. In: Kirchner, T., Lembcke, B., Kist, M. (eds) Ökosystem Darm VIII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59963-7_25

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  • DOI: https://doi.org/10.1007/978-3-642-59963-7_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64837-6

  • Online ISBN: 978-3-642-59963-7

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