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Ökosystem Darm VIII pp 233–245Cite as

Selektive Denervierung durch Botulinus-Toxin als therapeutisches Prinzip im Gastrointestinaltrakt

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Zusammenfassung

Gelangen ubiquitär im Erdreich und im Wasser vorkommende Clostridium-botulinum-Sporen in Fleisch-, Wurst- oder Gemüsekonserven, kann es unter Luftabschluß und bestimmten pH-Verhältnissen zur Umwandlung der Sporen in die Vegetativform kommen. Die Vegetativform des Bakteriums beginnt dann, Botulinus-Toxine zu bilden. Nach Ingestion solchermaßen kontaminierter Lebensmittel kommt es beim Menschen zu einer als Botulismus bezeichneten Intoxikation. Klinisch resultieren zunächst okuläre Symptome (Doppelbilder, Verschwommensehen, Ptose und weite, lichtstarre Pupillen) sowie gastrointestinale Beschwerden (Dysphagie, Übelkeit, Erbrechen, Bauchkrämpfe und Mundtrockenheit). Nachfolgend bilden sich umschriebene Paresen aus sowie eine Lähmung der Atemmuskulatur. In Zeiten, in denen eine maschinelle Ventilation noch nicht verfügbar war, besaß der Botulismus daher eine hohe Letalität.

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Authors
  1. T. Wehrmann
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Editors and Affiliations

  1. Pathologisch-Anatomisches Institut, Universität Erlangen-Nürnberg, Krankenhausstraße 8-10, D-91054, Erlangen, Germany

    Thomas Kirchner

  2. Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    Bernhard Lembcke

  3. Institut für Medizinische Mikrobiologie und Hygiene, Hermann-Herder-Straße 11, D-79104, Freiburg, Germany

    Manfred Kist

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© 1999 Springer-Verlag Berlin Heidelberg

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Wehrmann, T. (1999). Selektive Denervierung durch Botulinus-Toxin als therapeutisches Prinzip im Gastrointestinaltrakt. In: Kirchner, T., Lembcke, B., Kist, M. (eds) Ökosystem Darm VIII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59963-7_23

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  • DOI: https://doi.org/10.1007/978-3-642-59963-7_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64837-6

  • Online ISBN: 978-3-642-59963-7

  • eBook Packages: Springer Book Archive

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