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Bakteriell induzierte zelluläre Immunreaktion bei chronisch-entzündlichen Darmerkrankungen und Arthritiden

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Ökosystem Darm VIII

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Zusammenfassung

Die aktuelle Forschung hat das Verständnis bakteriell induzierter zellulärer Immunreaktionen in der Pathogenese von chronisch-entzündlichen Darmerkrankungen entscheidend erweitert und stellt u.a. die normale Darmflora als möglicherweise entscheidenden antigenen Immunstimulus in den Vordergrund. Darüber hinaus liefert sie neue faszinierende Einblicke darüber, wie das intestinale Immunsystem über die Achse Darm-Gelenke nicht nur Ausgangspunkt der CED-assoziierten, sondern auch anderer Formen von Spond-arthritiden sein kann. Aufgabe dieses Beitrags soll es daher sein, einige dieser Aspekte darzustellen.

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Literatur

  1. Aranda R, Sydora BC, McAllister PL et al. (1997) Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to sCID recipients. J Immunol 158:3464–3473.

    PubMed  CAS  Google Scholar 

  2. Benjamin R, Parham P (1992) HLA-B27 and disease: A consequence of inadvertent antigen presentation. Rheumatic Disease Clinics of North America 18:11–21.

    PubMed  CAS  Google Scholar 

  3. Breban M, Fernandezsueiro JL, Hadavand RR et al. (1996) T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. J Immunol 156:794–803.

    PubMed  CAS  Google Scholar 

  4. Chiodini RF, Rositer CA (1995) Role of mycobacteria in Crohn’s disease: immunological responses. In: Tytgat, Bartelsman, van Deventer (eds) Inflammatory Bowel Diseases. Kluwer Academic Publishers, Dordrecht, Boston, London, S. 437–450.

    Google Scholar 

  5. Cong Y, McCabe RP, Seibold F et al. (1997) Clonal restriction of colitis-inducing, enteric bacterial antigen-specific CD4+ T cells. Gastroenterology 112 A:951.

    Google Scholar 

  6. Duchmann R, Kaiser I, Hermann E et al. (1995) Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 102:455.

    Google Scholar 

  7. Duchmann R, Märker-Hermann E, Meyer zum Büschenfelde KH (1996) Bacteria-specific T-cell clones are selective in their reactivity towards different enterobacteria or H. pylori and increased in inflammatory bowel disease. Scand J Immunol 44:71–79.

    Article  PubMed  CAS  Google Scholar 

  8. Duchmann R, May E, Ackermann B et al. (1996) HLA-B27-restricted cytotoxic T lymphocyte responses to arthritogenic enterobacteria or self-antigens are dominated by closely related TCRBV gene segments. A study in patients with reactive arthritis. Scand J Immunol 43:101–108.

    Article  PubMed  CAS  Google Scholar 

  9. Duchmann R, Schmitt E, Knolle P et al. (1996) Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur J Immunol 26:934–938.

    Article  PubMed  CAS  Google Scholar 

  10. Duchmann R, Neurath M, Märker-Hermann E, Meyer zum Büschenfeld KH (1997) Immune responses towards intestinal bacteria-current concepts and future perspectives. Z Gastroenterol 35:337–346.

    PubMed  CAS  Google Scholar 

  11. Duchmann R, May E, Heike M et al. (submitted) T cell specificity and crossreactivity towards enterobacteria, Bacteroides, Bifidobacterium and antigens from resident intestinal flora in man.

    Google Scholar 

  12. Ehrhardt RO, Ludviksson BR, Gray B et al. (1997) Induction and prevention of colonic inflammation in IL-2-deficient mice. J Immunol 158:566–573.

    PubMed  CAS  Google Scholar 

  13. Gammon G, Sercarz EE, Benichou G (1991) The dominant self and the cryptic self: shaping the autoreactive T-cell repertoire. Immunol Today 12:19.

    Article  Google Scholar 

  14. Gaston JSH (1997) Pathogenic role of gut inflammation in the spondylarthropathies. Curr Opin Rheumatol 9:302–307.

    Article  PubMed  CAS  Google Scholar 

  15. Granfors K, Jalkanen S, von Essen R et al. (1989) Yersinia antigens in synovial-fluid cells from patients with reactive arthritis. N Engl J Med 320:216–221.

    Article  PubMed  CAS  Google Scholar 

  16. Hermann E, Fleischer B, Mayet W (1989) Response of synovial fluid T cell clones to Yersinia enterocolitica antigens in patients with yersinia arthritis. Clin exp Immunol 75:365–370.

    PubMed  CAS  Google Scholar 

  17. Hermann E, Yu DT, Meyer zum Büschenfelde K-H, Fleischer B (1993) HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 34:646–650.

    Article  Google Scholar 

  18. Hermann E, Ackermann B, Duchmann R, Meyer zum Büschenfelde KH (1995) Synovial fluid MHC-unrestricted gamma delta-T lymphocytes contribute to antibacterial and anti-self cytotoxicity in the spondylarthropathies. Clin Exp Rheumatol 13:187–192.

    PubMed  CAS  Google Scholar 

  19. Kühn R, Löhler J, Rennick D et al. (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263–274.

    Article  PubMed  Google Scholar 

  20. Ludviksson BR, Gray B, Strober W, Ehrhardt RO (1997) Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes. J Immunol 158:104–111.

    PubMed  CAS  Google Scholar 

  21. Ma A, Datta M, Margosian E et al. (1995) T cells, but not B cells, are required for bowel inflammation in Interleukin 2-deficient mice. J Exp Med 182:1567–1572.

    Article  PubMed  CAS  Google Scholar 

  22. Märker-Hermann E, Duchmann R, May E et al. (1996) The T cell receptor (TCR) in HLA-B27-restricted T cell responses - an introduction. Clin Rheumatol 15 Suppl 1:86–90.

    Google Scholar 

  23. May E, Duchmann R, Ackermann B et al. (1996) TCRB junctional regions from HLA-B27-restricted T cells and HLA–B27 binding peptides display conserved hydropathy profiles in the absence of primary sequence homology. Int Immunol 8:1815–1823.

    Article  PubMed  Google Scholar 

  24. McEniff N, Eustace S, McCarthy C et al. (1996) Asymptomatic sacroiliitis in inflammatory bowel disease: assessment by computed tomography. Clin Imaging 19:258–262.

    Article  Google Scholar 

  25. Mielants H, Veys E, Cuvelier C et al. (1985) HLA-B27 related arthritis and bowel inflammation. Part 2: Ileocolonoscopy and bowel histology in patients with HLA-B27 related arthritis. J Rheumatol 12:294–298.

    PubMed  CAS  Google Scholar 

  26. Morrissey PJ, Charrier K (1994) Induction of Wasting disease in SCiD mice by the transfer of normal CDh4/CDh5RBh, T cells and the regulation of this autoreactivity by CDh4/ CDh5RBlo T cell, Res Immunol 145:357–362.

    Article  PubMed  CAS  Google Scholar 

  27. Neurath M, Fuss I, Kelsall BL et al. (1995) Antibodies to IL-12 abrogate established granulomatous colitis in mice. J Exp Med 182:1281–1290.

    Article  PubMed  CAS  Google Scholar 

  28. Neurath MF, Fuss I, Kelsall B et al. (1996) Experimental granulomatous colitis in mice is abrogated by induction of TGF-ß-mediated oral tolerance. J Exp Med 183:2605–2616.

    Article  PubMed  CAS  Google Scholar 

  29. Powrie F, Leach MW, Mauze S et al. (1994) Inhibition of Thl responses prevents inflammatory bowel disease in seid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1:553–562.

    Article  PubMed  CAS  Google Scholar 

  30. Powrie F, Carlino J, Leach MW et al. (1996) A critical role for transforming growth factor-bbb but not interleukin-4 in the suppression of T helper type-1-mediated colitis by CD45RBlow CD4+ cells. Exp Med 183:2669–2674

    Article  CAS  Google Scholar 

  31. Protzer U, Duchmann R, Hohler T et al. (1996) Enteropathic spondylarthritis in chronic inflammatory bowel diseases: prevalence, manifestation pattern and HLA association. Med Klin 91:330–335

    CAS  Google Scholar 

  32. Rath HC, Herfarth HH, Ikeda JS et al. (1996) Normal luminal bacteria, especially bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human ß2 microglobulin transgenic rats. J Clin Investigation 98:945–953

    Article  CAS  Google Scholar 

  33. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I (1993) Ulcerative Colitis-like disease in mice with a disrupted Interleukin-2 Gene. Cell 75:253–261

    Article  PubMed  CAS  Google Scholar 

  34. Sartor R, Rath H, Lichtman S, van Tol E (1996) Animal models of intestinal and joint inflammation. Baillieres Clin Rheumatol 10:55–76

    Article  PubMed  CAS  Google Scholar 

  35. Schlaak J, Hermann E, Ringhoffer M, Probst P et al. (1992) Predominance of Th1-type T cells in synovial fluid of patiens with Yersinia-induced reactive arthritis. Eur J Immunol 22:2771–2776

    Article  PubMed  CAS  Google Scholar 

  36. Simon AK, Seipelt E, Wu P (1993) Analysis of cytokine profiles in synovial T cell clones from chlamydial reactive arthritis patients: predominance of TH1 subset. Clin Exp Immunol 122–126

    Google Scholar 

  37. Spahn TW, Heimanns H, Duchmann R et al. (1997) Cellular and humoral immunity to the 60-kD heat-shock preotion in inflammatory bowel disease. Digestion 58:469–475

    Article  PubMed  CAS  Google Scholar 

  38. Strober W, Ehrhardt RO (1993) Chronic intestinal inflammation: an unexpected outcome in cytokine or T cell receptor mutant mice. Cell 75:203–205

    Article  PubMed  CAS  Google Scholar 

  39. Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez-Sueiro JL, Balish E, Hammer RE (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 180:2359–2364

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. R. Duchmann
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Editors and Affiliations

  1. Pathologisch-Anatomisches Institut, Universität Erlangen-Nürnberg, Krankenhausstraße 8-10, D-91054, Erlangen, Germany

    Thomas Kirchner

  2. Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    Bernhard Lembcke

  3. Institut für Medizinische Mikrobiologie und Hygiene, Hermann-Herder-Straße 11, D-79104, Freiburg, Germany

    Manfred Kist

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© 1999 Springer-Verlag Berlin Heidelberg

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Duchmann, R. (1999). Bakteriell induzierte zelluläre Immunreaktion bei chronisch-entzündlichen Darmerkrankungen und Arthritiden. In: Kirchner, T., Lembcke, B., Kist, M. (eds) Ökosystem Darm VIII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59963-7_12

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  • DOI: https://doi.org/10.1007/978-3-642-59963-7_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64837-6

  • Online ISBN: 978-3-642-59963-7

  • eBook Packages: Springer Book Archive

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