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Morbus Whipple

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Darmkrankheiten

Zusammenfassung

Der M. Whipple ist eine systemische bakterielle Krankheit, die hauptsächlich die männliche weiße Bevölkerung im mittleren Lebensalter betrifft mit Befall des Darms und seiner Lymphabflußwege, des Herzens, der Gelenke sowie des Zentralnervensystems (ZNS). Sie ist durch folgende Symptome gekennzeichnet: Arthralgien, Durchfälle, abdominelle Schmerzen Gewichtsverlust. Weitere häufige Symptome sind: Lymphadenopathie, Fieber, verstärkte Pigmentierung der Haut. Die Gewebe zeigen eine Infiltration mit Makrophagen, die sich intensiv PAS-positiv anfärben.

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Literatur

  • Chears WCJ, Ashworth CT (1961) Electron microscopic study of the intestinal mucosa in Whipple’s disease: demonstration of encapsulated bacilliform bodies in the lesion. Gastroenterology 41:129–138

    PubMed  Google Scholar 

  • Cohen AS, Schimmel EM, Holt PR, Isselbacher KJ (1960) Ultra-structural abnormalities in Whipple’s disease. Proc Soc Exp Biol Med 105:411–415

    PubMed  CAS  Google Scholar 

  • Cooper GS, Blades EW, Remler BF, Salata RA, Bennert KW, Jacobs GH (1994) Central nervous system Whipple’s disease: relapse during therapy with trimethoprim-sulfamethoxazone and remission with Cefixime. Gastroenterology 106:782–786

    PubMed  CAS  Google Scholar 

  • Dobbins WO III, Kawanishi H (1981) Bacillary characteristics in Whipple’s disease: an electronmicroscopic study. Gastroenterology 80:1468–1474

    PubMed  Google Scholar 

  • Dobbins WO III (1987) Whipple’s disease, Springfield, Ill.: Charles C Thomas

    Google Scholar 

  • Donaldson RM (1992) Whipple’s disease — rare malady with uncommon potential. New Engl J Med 327:346–348

    Article  PubMed  Google Scholar 

  • Feurle GE, Volk B, Waldherr R (1979) Cerebral Whipple’s disease with negative jejunal histology. New Engl J Med 300:907–908

    Article  PubMed  CAS  Google Scholar 

  • Keinath RD, Merrell DE, Vlietstra R, Dobbins WO III (1985) Antibiotic treatment and relapse in Whipple’s disease. Long-term follow-up of 88 patients. Gastroenterology 88: 1867–1873

    PubMed  CAS  Google Scholar 

  • Marth T, Neurath M, Cuccherini BA, Strober W (1997) Defects of monocyte interleukin 12 production and humoral immunity in Whipple’s disease. Gastroenterology 113:442–448

    Article  PubMed  CAS  Google Scholar 

  • Müller C, Petermann D, Stain C, Riemer H, Vogelsang H, Schnider P et al. (1997) Whipple’s disease: comparison of histology with diagnosis based on polymerase chain reaction in four consecutive cases. Gut 40:425–427

    PubMed  Google Scholar 

  • Relman DA, Schmidt TM, MacDermott RP, Falkow S (1992) Identification of the uncultered bacillus of Whipple’s disease. New Engl J Med 327:293–301

    Article  PubMed  CAS  Google Scholar 

  • Ryser RJ, Locksley RM, Eng SC, Dobbins WO III, Schoenknecht FD, Rubin CE (1984) Reversal of dementia associated with Whipple’s disease by trimethoprim-sulfametoxazole, drugs that penetrate the blood-brain barrier. Gastroenterology 86:745–752

    PubMed  CAS  Google Scholar 

  • Schnider PJ, Reisinger EC, Gerschlager W, Müller C, Berger T, Krejs G et al. (1996) Long-term follow-up in cerebral Whipple’s disease. Europ J Gastroenterol Hepatol 8:899–903

    CAS  Google Scholar 

  • von Herbay A, Ditton H, Maiwald M (1996) Diagnostic application of a polymerase chain reaction assay for the Whipple’s disease bacterium to intestinal biopsies. Gastroenterology 110:1735–1743

    Article  Google Scholar 

  • von Herbay A, Maiwald M, Ditton H-J, Otto HF (1996) Histology of intestinal Whipple’s disease revisited. A study of 48 patients. Virchows Arch 335–343

    Google Scholar 

  • von Herbay A, Ditton H-J, Schuhmacher F, Maiwald M (1997) Whipple’s disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid. Gastroenterology 113:434–441

    Article  Google Scholar 

  • von Herbay A, Otto HF, Stolte M, Borchard, F, Ditton H-J, Maiwald M (1997) Epidemiology of Whipple’s disease in Germany. Analysis of 110 patients diagnosed in 1965–1995. Scand J Gastroenterol 32:52–57

    Article  Google Scholar 

  • Whipple GH (1907) A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissue. Bull Johns Hopkins Hosp 18:382–391

    CAS  Google Scholar 

  • Wilson KH, Blitchington R, Frothingham R, Wilson JAP (1991) Phylogeny of the Whipple’s-disease-associated bacterium. Lancet 338:474–475

    Article  PubMed  CAS  Google Scholar 

  • Yardley JH, Hendrix TR (1961) Combined electron and light microscopy in Whipple’s disease: demonstration of „bacillary bodies“ in the intestine. Bull Johns Hopkins Hosp 109:80–98

    PubMed  CAS  Google Scholar 

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© 1999 Springer-Verlag Berlin Heidelberg

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von Arnim, U., Caspary, W.F. (1999). Morbus Whipple. In: Caspary, W.F., Stein, J. (eds) Darmkrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59960-6_26

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  • DOI: https://doi.org/10.1007/978-3-642-59960-6_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64197-8

  • Online ISBN: 978-3-642-59960-6

  • eBook Packages: Springer Book Archive

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