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Immunology of Infection

  • Chapter
Vaccines

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 133))

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Abstract

Vaccinology can be viewed as an application of immunology. The two disciplines arose from a common root in the late nineteenth century, namely investigations of the host response to infectious agents. Emil von Behring, in studying the humoral immune response to the toxin-producing pathogens Clostridium tetani and Corynebacterium diphtheriae, realized the implication of his observation that protection can be transferred with sera from immunized animals (VON BEHRING 1915). In developing the therapeutic strategy of passive vaccination he relied on antibody quantifications developed by Paul Ehrlich (1904). Soon, however, vaccinology and immunology diverged. The vaccines in current use were often developed empirically and virtually independently of the progress made in basic immunology. This approach has now reached its limits. Novel vaccine generations are required for infectious diseases that still cause enormous health problems, and for which vaccines are not yet available. These vaccines can be developed only in the realm of modern immunology. Recent advances in immunology have provided insights into the specific, anti-infective protection and have thereby supplied the tools for selective stimulation of appropriate immune responses K(AUFMANN 1996a).

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Authors
  1. S. H. E. Kaufmann
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  2. J. Reimann
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Editors and Affiliations

  1. The Wenner-Gren Institute Department of Immunology The Arrhenius Laboratories F5, Stockholm University, S-106 91, Stockholm, Sweden

    Peter Perlmann (Professor) (Professor)

  2. MTC, Karolinska Institute, S-171 77, Stockholm, Sweden

    Hans Wigzell (Professor) (Professor)

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© 1999 Springer-Verlag Berlin Heidelberg

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Kaufmann, S.H.E., Reimann, J. (1999). Immunology of Infection. In: Perlmann, P., Wigzell, H. (eds) Vaccines. Handbook of Experimental Pharmacology, vol 133. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59955-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-59955-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64196-1

  • Online ISBN: 978-3-642-59955-2

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