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Mycobacteria

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Vaccines

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 133))

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Abstract

Mycobacterium tuberculosis, the causative agent of tuberculosis, is expected to cause 30 million deaths in the coming 10 years — more than any other single infectious agent. The current vaccine against tuberculosis, bacille Calmette-Guérin (BCG), has a highly variable record of protection, and a widely accepted need exists for improved vaccines to control this disease. Infection with tuberculosis triggers a broad spectrum of immune responses which can contribute to elimination of the pathogen and to disease-associated pathology. In an ideal world a complete understanding of these responses would have provided an optimal rational design for improved prophylactic, or therapeutic, vaccines against tuberculosis and other mycobacterial diseases such as leprosy. However, the complexity of this immune response has thus far confronted us with a formidable obstacle, and novel vaccine strategies currently are still based on more pragmatic arguments. In the first part of this chapter we summarise the current knowledge of the host response to mycobacterial pathogens in order to highlight its complex role in protection and disease. The second part describes current approaches taken to produce novel, improved vaccines against mycobacterial pathogens.

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References

  • Adams E, Basten A, Rodda S, Britton WJ (1997) Human T-cell clones to the 70-kilodalton heat shock protein of Mycobacterium leprae define Mycobacterium specific epitopes rather than shared epitopes. Infect Immun 65:1061–1070

    PubMed  CAS  Google Scholar 

  • Andersen P (1994) Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 62:2536–2544

    PubMed  CAS  Google Scholar 

  • Andersen P Heron I (1993) Specificity of a protective memory immune response against Mycobacterium tuberculosis. Infect Immun 61:844–851

    PubMed  CAS  Google Scholar 

  • Andersen P Askgaard D, Ljungqvist L, Bennedsen J, Heron I (1991) Proteins released from Mycobacterium tuberculosis during growth. Infect Immun 59:1905–1910

    PubMed  CAS  Google Scholar 

  • Armstrong JA, Hart PD (1975) Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival. J Exp Med 142:1–16

    Article  PubMed  CAS  Google Scholar 

  • Balasubramanian V, Pavelka M Jr, Bardarov SS, Martin J, Weisbord TR, McAdam RA, Bloom BR, Jacobs W Jr (1996) Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates. J Bacteriol 178:273–279

    PubMed  CAS  Google Scholar 

  • Barker LP, George KM, Falkow S, Small PLC (1997) Differential Trafficking of live and dead Mycobacterium marinum organisms in macrophages. Infect Immun 65:1497–1504

    PubMed  CAS  Google Scholar 

  • Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB (1994) Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells. Nature 372:691–694

    Article  PubMed  CAS  Google Scholar 

  • Behr C, Poupot R, Peyrat MA, Poquet Y, Constant P, Dubios P, Bonneville M, Fournie JJ (1996) Plasmodium falciparum stimuli for human gammadelta T cells are related to phosphorylated antigens of mycobacteria. Infect Immun 64:2892–2896

    PubMed  CAS  Google Scholar 

  • Bloom BR, Fine PEM (1994) The BCG experience:implications for future vaccines against tuberculosis. In:Bloom BR (ed) The BCG experience:implications for future vacines against tuberculosis. ASM, Washington DC, pp 531–558

    Google Scholar 

  • Chan J, Kaufmann SHE (1994) Immune mechanisms of protection. In:Bloom, BR (ed) Immune mechanisms of protection. ASM, Washington DC, pp 389–416

    Google Scholar 

  • Chan J, Xing Y, Magliozzo RS, Bloom BR (1992) Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med 175:1111–1122

    Article  PubMed  CAS  Google Scholar 

  • Chatterjee D, Roberts AD, Lowell K, Brennan PJ, Orme IM (1992) Structural basis on capacity of lipoarabinomannan to induce secretion of tumor necrosis factor. Infect immune 60:1249–1253

    CAS  Google Scholar 

  • Clemens DL, Horwitz MA (1995) Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J Exp Med 181:257–270

    Article  PubMed  CAS  Google Scholar 

  • Colditz GA, Brewer TF, Berkey CS, Wilson ME, Burdick E, Fineberg HV, Mosteller F (1994) Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA 271:698–702

    Article  PubMed  CAS  Google Scholar 

  • Convit J, Sampson C, Zuniga M, Smith PG, Plata J, Silva J, Molina J, Pinardi ME, Bloom BR, Salgado A (1992) Immunoprophylactic trial with combined Mycobacterium leprae/BCG vaccine against leprosy:preliminary results. Lancet 339:446–450

    Article  PubMed  CAS  Google Scholar 

  • Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM (1993) Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178:2243–2247

    Article  PubMed  CAS  Google Scholar 

  • Copper AM, D’Souza C, Frank AA, Orme IM (1997) The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin-or grandzyme-mediated cytolytic mechanisms. Infect Immun 65:1317–1320

    Google Scholar 

  • Dannenberg AM Rook GAW (1994) Pathogenesis of pulmonary tuberculosis:an interplay of tissue- damaging and macrophage-activating immune responses - dual mechanisms that control bacillary multiplication. In:Bloom BR (ed) Pathogenesis of pulmonary tuberculosis:an interplay of tissue-damaging and macrophage activating immune responses-dual mechanisms that control bacillary multiplication. ASM, Washington, pp 459–484

    Google Scholar 

  • de-Cock KM (1994) Impact of interaction with HIV. In:Porter JDH, McAdam KPWJ (eds) Impact of interaction with HIV. Wiley, Chichester, pp 35–49

    Google Scholar 

  • Denis M (1991) Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates. Cell immunol 132:150–157

    Article  PubMed  CAS  Google Scholar 

  • Denis O, Lozes E, Huygen K (1997) Induction of cytotoxic T-cell responses against culture filtrate antigens in Mycobacterium bovis bacillus Calmette-Guerin-infected mice. Infect Immun 65:676–684

    PubMed  CAS  Google Scholar 

  • Ding AH, Nathan CF, Stuehr DJ (1998) release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 141:2407–2412

    Google Scholar 

  • D’Souza CD, Cooper AM, Frank AA, Mazzaccaro RJ, Bloom BR, Orme IM (1997) An anti-inflammatory role for γδT lumphocytes in acquired immunity to Mycobacterium tuberculosis. J Immunol 158:1217–1221

    PubMed  Google Scholar 

  • Flesch IEA, Kaufmann SHE (1991) Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages:role of reactive nitrogen intermediates. Infect Immun 59:3213–3218

    PubMed  CAS  Google Scholar 

  • Flynn JL, Goldstein MM, Triebold KJ, Koller B, Bloom BR (1992) Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci USA 89:12013–12017

    Article  PubMed  CAS  Google Scholar 

  • Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR (1993) An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 178:2249–2254

    Article  PubMed  CAS  Google Scholar 

  • Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schreiber R, Mak TW, Bloom BR (1995) Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2:561–572

    Article  PubMed  CAS  Google Scholar 

  • Fulton SA, Johnsen JM, Wolf SA, Sieburth DS, Boom WH (1996) Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis:role of phagocytosis. Infect Immun 64:2523–2531

    PubMed  CAS  Google Scholar 

  • Gelber RH, Murray L, Siu P, Tsang M (1992) Vaccination of mice with a soluble protein fraction of Mycobacterium leprae provides consistent and long- term protection against M. leprae infection. Infect Immun 60:1840–1844

    PubMed  CAS  Google Scholar 

  • Gelber RH, Mehra V, Bloom B, Murray LP, Siu P, Tsang m, Brennan PJ (1994) Vaccination with pure Mycobacterium leprae proteins inhibits M. Leprae proteins inhibits M. leprace multiplication in mouse footpads. Infect Immun 62:4250 - 4255

    PubMed  CAS  Google Scholar 

  • Guleria I, McAdam RA, Kalpana G, Jacobs WR, Bloom BR (1996) Auxotrophic vaccines for tuberculosis. Nature Med 2:334 - 337

    Article  PubMed  CAS  Google Scholar 

  • Hasan Z, Schlax C, Kuhn L, Lefkovits I, Young D, Thole J, Pieters J (1997) Isolation and characterization of the mycobacterial phagosome:segregation from the endosomal/lysosomal pathway. Mol Microbiol

    Google Scholar 

  • Hermann JL, O’Gaora p, Gallagher A, Thole JER, Young DB (1996) Bacterial glycoproteins:a link between glycosylation and proteolytic cleavage of a 19 kDa antigen from Mycobacterium tuberculosis. EMBO 15:3547–3554

    Google Scholar 

  • Hsieh CS, MAcatonia SE, Tripp CS, Wolf SF, O’Gara A, Murphy KM (1993) Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547–549

    Article  PubMed  CAS  Google Scholar 

  • Huygen K, Content J, Denis O, Montgomery DL, Yawman AM, Deck RR, Dewitt CM, Orme IM, Baldwin S, D’Souza C, Drowart A, Lozes E, Vanden bussche P, Van Vooren J-P, Liu MA, Ulmer JB (1996) Imunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat. Med 2:893–898

    Article  PubMed  CAS  Google Scholar 

  • Inaba K, Inaba M, Naito M, Steinman RM (1993) Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med 178:479–488

    Article  PubMed  CAS  Google Scholar 

  • Karonga Prevention Trial Group (1996) Randomised controlled trial of single BCG, prevention of repeated BCG, or combined BCG and killed Mycobacterium leprosy vaccine for prevention of leprosy and tuberculosis in Malawi. Lancet 348:172–24

    Google Scholar 

  • Ladel CH, Blum C, Dreher A, Reifenberg K, Kaufmann SH (1995) Protective role of gamma/delta T cells and alpha/beta T cells in tuberculosis. Eur J Immunol 25:2877–2881

    Article  PubMed  CAS  Google Scholar 

  • Lin Y, Zhang M, Hofman FM, Gong J, Barnes PF (1996) Absence of a prominent Th2 cytokine response in human tuberculosis. Infect Immun 64:1351–1356

    PubMed  CAS  Google Scholar 

  • Lindblad ER, Elhay MJ, Silva R, Appelberg R, Andersen P (1997) Adjuvant modulation of immune responses to tuberculosis subunit vaccines. Infect immune 65:623–629

    CAS  Google Scholar 

  • Mahairas GC, Sabo PJ, Hickey MJ, Singh DC, Stover CK (1996) Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J Bacteriol 178:1274–1282

    PubMed  CAS  Google Scholar 

  • Marshall BG, Chambers MA, Wangoo A, Shaw RJ, Young DB (1997) Production of tumor necrosis factor and nitric oxide by macrophages infected with live and dead mycobacteria and their suppression by an interleukin-10-secreting recombinant. Infect Immun

    Google Scholar 

  • Mazzaccaro RJ, Gedde M, Jensen ER, van Santen HM, Ploegh HL, Rock KL, Bloom BR (1996) Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. Proc Natl Acad Sci USA 93:11786–11791

    Article  PubMed  CAS  Google Scholar 

  • McAdam RA, Weisbrod TR, Martin J, Scuderi JD, Brown AM, Cirillo JD, Bloom BR, Jacobs WR (1995) In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenisis. Infect Immun 63:1004–1012

    PubMed  CAS  Google Scholar 

  • McDonough KA, Kress Y, Bloom BR (1993) Pathogenesis of tuberculosis:interaction of Mycobacterium tuberculosis with macrophages. Infect Immun 61:2763 - 2773

    PubMed  CAS  Google Scholar 

  • Murray PJ, Aldovini A, Young RA (1996) Manipulation and potentiation of antimycobacterial immunity using recombinant bacilli Calmette-Guerin strains that secrete cytokines. Proc Natl Acad Sci USA 93:934–939

    Article  PubMed  CAS  Google Scholar 

  • Newport MJ, Huxley CMP, Huston S, Hawrylowycz C, Oostra BA, Williamson R. Levin M (1996) Mutation in the interferon-γreceptor and mycobacterial susceptibility in man. N Engl J Med 335:1941–1949

    Article  PubMed  CAS  Google Scholar 

  • Nicholson S, da Bonecini Almeida MG, Lapa e Silva JR, Nathan C, Xie QW, Mumford R, Weidner JR, Calaycay J, Geng J, Boechat N, Linhares C, Rom W, Ho JL (1996) Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. J Exp Med 183:2293–2302

    Article  PubMed  CAS  Google Scholar 

  • Nussler Ak, Billiar TR (1993) Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukocyte Biol 54:171–178

    PubMed  CAS  Google Scholar 

  • O’Brien RL, Happ MP, Dallas A, Palmer E, Kubo R, Born WK (1989) Stimulation of a major subset of lymphocytes expressing T cell receptor gammadelta by an antigen derived from Mycobacterium tuberculosis. Cell 57:667–674

    Article  PubMed  Google Scholar 

  • O’Donnell MA, Aldovini A. Duda RB, Yang H, Szilvasi A, Young RA, DeWolf WC (1994) Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes. Infect Immun 62:2508–2514

    PubMed  Google Scholar 

  • Orme IM, Anderson P, Boom WH (1993) T cell response to Mycobacterium tuberculosis. J Infect Dis 167:1481–1497

    Article  PubMed  CAS  Google Scholar 

  • Ottenhoff THM, Mutis T (1990) Specific killing of cytotoxic T cells and antigen presenting cells by cytotoxic CD4+ T cell clones. A novel potentially immunoregulatory T-T cell interaction in man. J Exp Med 171:2011–2024

    Article  PubMed  CAS  Google Scholar 

  • Pal PG, Horwitz MA (1992) Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell–mediated immune responses and substantial protective immunity n a guinea pig model of pulmonary tuberculosis. Infect Immun 60:4781–4792

    PubMed  CAS  Google Scholar 

  • Pancholi P, Mirza A, Bhardwaj N. Steinman RM (1993) Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages. Science 260:984–986

    Article  PubMed  CAS  Google Scholar 

  • Pelicic V, Reyrat JM, Gicquel B (1996) Expression of the subtilis sacB gene confers sucrose sensitivity on mycobacteria. J Bacteriol 178:1197–1199

    PubMed  CAS  Google Scholar 

  • Philipp WJ, Nair S, Guglielmi G, Lagandrie M, Gicquel B, Cole ST (1996) physical mapping of Mycobacterium bovis BCG Pasteur reveals differences from the genome maps of Mycobacterium tuberculosis H37Rv and M. bovis. Microbiology 142:3135–3145

    Article  PubMed  CAS  Google Scholar 

  • Ponnighaus JM, Fine PE, Sterne JA, Wilson RJ, Msosa E, Gruer PJ, Jenkins PA, Lucas SB, Liomba NG, Bliss L (1992) Efficacy of BCG vaccine against leprosy and tuberculosis in northern Malawi. Lancet 339:636–639

    Article  PubMed  CAS  Google Scholar 

  • Reyrat JM, Berthet FX, Gicquel B (1995) The urease locus of M. tuberculosis and its utilisation for the demonstration of allelic exchange in M. bovis BCG. Proc Natl Acad Sci USA 92:8768–8772

    Article  PubMed  CAS  Google Scholar 

  • Rook GAW, Hernandez-Pando R (1996) the pathogenesis of tuberculosis. Annu Rev Microbiol 50:259–284

    Article  PubMed  CAS  Google Scholar 

  • Sampaio EP, Kaplan G, Miranda A, Nery JA, Miguel CP, Viana SM, Sarno EN (1993) The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum. J Infect Dis 168:408–414

    Article  PubMed  CAS  Google Scholar 

  • Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ (1995) CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269:227–230

    Article  PubMed  CAS  Google Scholar 

  • Silva CL, Lowrie DB (1994) A single mycobacterial protein (hsp 65) expressed by a transgenic antigen-presenting cell vaccinates mice against tuberculosis. Immunology 82:224–248

    Google Scholar 

  • Silva CL, Silva RC, Pietro RCLR, Lowrie DB (1994) Protection against tuberculosis by passive transfer with T-cell clones recognising mycobacterial heat-shock protein 65. Immunology 83:341–346

    PubMed  CAS  Google Scholar 

  • Sorensen AL, Nagai S, Houen G, Andersen P, Andersen AB (1995) Purification and characterisation of a low- molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect Immun 63:1710–1717

    PubMed  CAS  Google Scholar 

  • Stover CK, de la Cruz VF, Fuerst TR, Burlein JE, Benson LA, Bennett LT, Bansal GP, Young JF, Lee MH, Hatfull GF et al (1991) New use of BCG for recombinant vaccines. Nature 351:456–460

    Article  PubMed  CAS  Google Scholar 

  • Sturgill-Koszycki S, Schlesinger PH, Charkraborty P, Haddix PL, Collins HL, Fok AK, Allen RD, Gluck SL,Heuser J, Rusell DG (1994) Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263:678–681

    CAS  Google Scholar 

  • Sugita M, Jackman RM, van-Donselaar E, Behar SM, Rogers RA, Peters PJ, Brenner MB, Porcelli SA (1996) Cytoplasmic tail-dependent localization of CD1b antigen presenting molecules to MIICs. Science 273:349–352

    Article  PubMed  CAS  Google Scholar 

  • Tanaka Y, Sano S, Nieves E, DeLibero G, Rosa D, Modlin R, Brenner MB, Bloom BR, Morita CT (1994) Nonpeptide ligands for human gammadelta T cells. Proc Natl Acad Sci USA 91:8175–8179

    Article  PubMed  CAS  Google Scholar 

  • Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR (1995) Natural and synthetic non- peptide antigens recognized by human gamma delta T cells. Nature 375:155–158

    Article  PubMed  CAS  Google Scholar 

  • Tascon RE, Colston MJ, Tagno S, Stavropoulos E, Gregory D, Lowrie DB (1996) Vaccination against tuberculosis by DNA injection. Nature Med 2:888–892

    Article  PubMed  CAS  Google Scholar 

  • Thole JER, Wieles B, Clark-Curtiss JE, Ottenhoff THM, Rinke de Wit TF (1995) Immunological and functional characterization of Mycobacterium leprae protein antigens:an overview. Mol Microbiol 18:791–800

    Article  PubMed  CAS  Google Scholar 

  • Toossi Z, Gogate P, Shiratsuchi H, Young T, Ellner JJ (1995) Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions. J immunol 154:465–473

    PubMed  CAS  Google Scholar 

  • Turk BE, Jiang H, Liu JO (1996) Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci USA 93:7552–7556

    Article  PubMed  CAS  Google Scholar 

  • Turner J, Dockrell H (1996) Stimulation of human peripheral blood mononuclear cells with live Mycobacterium bovis BCG activates cytolytic CD8+ T cells in vitro. Immunology 8:339–342

    Article  Google Scholar 

  • van Eden W (1991) Heat shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis. Immunol Rev 121:5–28

    Article  PubMed  Google Scholar 

  • VanHeyningen TK, Collins H, Russell DG (1997) IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses. J Immunol 158:330–337

    PubMed  CAS  Google Scholar 

  • Weltman AC, Rose DN (1993) The safety of Bacille Calmette-Guerin vaccination in HIV infection and AIDS. Aids 7:149–157

    Article  PubMed  CAS  Google Scholar 

  • Whalen C, Horsburgh CR, Hom D, Lahart C. Simberkoff M, Ellner J (1995) Accelerated course of human immunodefiency virus infection after tuberculosis. Am J Respir Crit Care Med 151:129–135

    PubMed  CAS  Google Scholar 

  • Yammura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modlin RL (1991) Defining protective responses to pathogens:cytokine profiles in leprosy lesions. Science 254:277–279

    Article  Google Scholar 

  • Young D, Lathigra R, Hendrix R, Sweetser D, Young RA (1988) Stress proteins are immune targets in leprosy and tuberculosis. Proc Natl Acad Sci USA 85:4267–4270

    Article  PubMed  CAS  Google Scholar 

  • Young DB, Garbe TR (1991) Lipoprotein antigens of Mycobacterium tuberculosis. Res microbial 142:55–65

    Article  CAS  Google Scholar 

  • Young DB, Kaufmann SH, Hermans PW, Thole JE (1992) Mycobacterial protein antigens:a compilation. Mol Microbiol 6:133–145

    Article  PubMed  CAS  Google Scholar 

  • Zaheer SA, Mukherjee R, Ramkumar B, Misra RS, Sharma AK, Kar HK, Kaur H, Nair S, Mukherjee A, Talwar GP (1993) Combined multidrug and Mycobacterium w vaccine therapy in patients with multibacillary leprosy. J Infect Dis 167:401–410

    Article  PubMed  CAS  Google Scholar 

  • Zhang M, Lin Y, Iyer DV, Gong J, Abrams JS, Barnes PF (1995) T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect Immun 63:3231–3234

    PubMed  CAS  Google Scholar 

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Authors
  1. R. Janssen
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  2. D. Young
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  3. J. Thole
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Editors and Affiliations

  1. The Wenner-Gren Institute Department of Immunology The Arrhenius Laboratories F5, Stockholm University, S-106 91, Stockholm, Sweden

    Peter Perlmann (Professor) (Professor)

  2. MTC, Karolinska Institute, S-171 77, Stockholm, Sweden

    Hans Wigzell (Professor) (Professor)

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© 1999 Springer-Verlag Berlin Heidelberg

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Janssen, R., Young, D., Thole, J. (1999). Mycobacteria. In: Perlmann, P., Wigzell, H. (eds) Vaccines. Handbook of Experimental Pharmacology, vol 133. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59955-2_11

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  • DOI: https://doi.org/10.1007/978-3-642-59955-2_11

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