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The Angiopoietins: Yin and Yang in Angiogenesis

  • Chapter
Vascular Growth Factors and Angiogenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 237))

Abstract

Embryonic vascular development involves a complex series of events during which endothelial cells differentiate, proliferate, migrate, and undergo morphological organization in the context of their surrounding tissues (Risau 1991, 1995). Vascular development is generally classified into two successive phases. The first, known as vasculogenesis, refers to the process whereby newly differentiated endothelial cells spontaneously coassemble into tubules that fuse to form a rather homogeneous primary vasculature in the embryo. Subsequent remodeling of this primary vascular network into large and small vessels brings into play a different process, termed angiogenesis. Angiogenesis in the embryo also leads to the sprouting of vessels into certain initially avascular organs, such as the brain. In the adult, angiogenesis accounts for neovascularization that accompanies the normal remodeling of the female reproductive organs during the menstrual cycle and pregnancy, in wound healing, and in various clinically significant pathological processes, such as tumor growth and diabetic retinopathy (Folkman 1995; Ferrara 1995; Hanahan and Folkman 1996).

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Authors and Affiliations

  1. Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA

    S. Davis & G. D. Yancopoulos

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  1. S. Davis
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  2. G. D. Yancopoulos
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Editors and Affiliations

  1. Department of Medical Biochemistry and Microbiology Biomedical Center, University of Uppsala, Box 575, Uppsala, S-75123, Sweden

    Lena Claesson-Welsh

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© 1999 Springer-Verlag Berlin Heidelberg

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Davis, S., Yancopoulos, G.D. (1999). The Angiopoietins: Yin and Yang in Angiogenesis. In: Claesson-Welsh, L. (eds) Vascular Growth Factors and Angiogenesis. Current Topics in Microbiology and Immunology, vol 237. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59953-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-59953-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64195-4

  • Online ISBN: 978-3-642-59953-8

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