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Functions of Tie1 and Tie2 Receptor Tyrosine Kinases in Vascular Development

  • Chapter
Book cover Vascular Growth Factors and Angiogenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 237))

Abstract

Vascularization of the mouse embryo is accomplished via the collaboration of two major cellular processes. Differentiation of vascular endothelial cells de novo from their precursors, called the angioblasts, has been termed vasculogenesis (Risau 1997). Somewhat confusingly, the term vasculogenesis has also been used in a broader sense, covering all aspects of vascular development (Dumont et al. 1994; Noden 1991; Sherer 1991; Wilting and Christ 1996). Subsequent expansion of the endothelium by remodelling, migration and proliferation is called angiogenesis. Vasculogenesis is known to occur intraembryonically within the splanchnopleural and paraxial mesoderm, as well as extraembryonically in the yolk sac mesoderm, and is responsible for laying down the primitive vascular network (Pardanaud et al. 1996; Wilting and Christ 1996). Vasculogenesis is characterized by angioblast differentiation and by either the immediate aggregation of angioblast cells to give rise to endothelium, or the directed migration of these cells through the embryo to segregate eventually into vascular cords. Interestingly, angioblasts appear to have different characteristics depending on their site of origin (Pardanaud et al. 1996). Vasculogenesis both in the yolk sac and in the splanchnic mesoderm appears closely linked to haemangioblast (Pardanaud et al. 1989; Shalaby et al. 1995, 1997).

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Authors and Affiliations

  1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada

    J. Partanen

  2. Amgen and Ontario Cancer Institutes, Department of Medical Biophysics, University of Toronto, Toronto, 620 University Avenue, Ontario, M5G 1C5, Canada

    D. J. Dumont

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  1. J. Partanen
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  1. Department of Medical Biochemistry and Microbiology Biomedical Center, University of Uppsala, Box 575, Uppsala, S-75123, Sweden

    Lena Claesson-Welsh

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Partanen, J., Dumont, D.J. (1999). Functions of Tie1 and Tie2 Receptor Tyrosine Kinases in Vascular Development. In: Claesson-Welsh, L. (eds) Vascular Growth Factors and Angiogenesis. Current Topics in Microbiology and Immunology, vol 237. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59953-8_8

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  • DOI: https://doi.org/10.1007/978-3-642-59953-8_8

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