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Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines pp 33–53Cite as

Dendritic Cells and Langerhans Cells in the Uptake of Mucosal Antigens

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 236))

Abstract

Dendritic cells (DC) represent heterogenous populations of bone marrow-derived cells that have central roles in the initiation and regulation of immune responses (reviewed in Steinman 1991). The cells under consideration are quite distinct from the follicular DCs found in B-cell areas of lymphoid tissues. It is, however, now clear that there is not a single DC lineage, but that cells with DC properties may arise from at least three lineages and can exist in different states of maturation and activation. The relationships between these lineages and their functional significance in immune responses are far from clear.

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References

  • Adema GJ, Hartgers F, Verstraten R, et al. (1997) A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature 387:713–717

    Article  PubMed  CAS  Google Scholar 

  • Agger R, Crowley MT, Witmer-Pack MD (1990) The surface of dendritic cells in the mouse as studied with monoclonal antibodies. Int Rev Immunol 6:89–101

    Article  PubMed  CAS  Google Scholar 

  • Ardavin C, Wu L, Li CL, et al. (1993) Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362:761–763

    Article  PubMed  CAS  Google Scholar 

  • Austyn JM, Hankins DF, Larsen CP, et al. (1994) Isolation and characterization of dendritic cells from mouse heart and kidney. J Immunol 152:2401–2410

    PubMed  CAS  Google Scholar 

  • Bhardwaj N, Bender A, Gonzalez N, et al. (1994) Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8 + T cells. J Clin Invest 94:797–807

    Article  PubMed  CAS  Google Scholar 

  • Blank C, Fuchs H, Rappersberger K, et al. (1993) Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major. J Infect Dis 167:418–425

    Article  PubMed  CAS  Google Scholar 

  • Brenan M, Puklavec M (1992) The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin. J Exp Med 175:1457–1465

    Article  PubMed  CAS  Google Scholar 

  • Bronte V, Carroll MW, Goletz TJ, et al. (1997) Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine. Proc Natl Acad Sci USA 94:3183–3188

    Article  PubMed  CAS  Google Scholar 

  • Bujdoso R, Hopkins J, Dutia BM, et al. (1989) Characterisation of sheep afferent lymph dendritic cells and their role in antigen carriage. J Exp Med 170:1285–1302

    Article  PubMed  CAS  Google Scholar 

  • Cameron P, Pope M, Granelli Piperno A, Steinman RM (1996) Dendritic cells and the replication of HIV-1. J Leukoc Biol 59:158–171

    PubMed  CAS  Google Scholar 

  • Cameron PU, Lowe MG, Crowe SM, et al. (1994) Susceptibility of dendritic cells to HIV-1 infection in vitro. J Leukoc Biol 56:257–265

    PubMed  CAS  Google Scholar 

  • Caux C, Massacrier C, Vanbervliet B, et al. (1994) Activation of human dendritic cells through CD40 cross-linking. J Exp Med 180:1263–1272

    Article  PubMed  CAS  Google Scholar 

  • Cella M, Scheidegger D, Palmer K, et al. (1996) Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 184:747–752

    Article  PubMed  CAS  Google Scholar 

  • Cella M. Sullusto F, Lanzavecchia (1997) Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 9:10–16

    Article  PubMed  CAS  Google Scholar 

  • Conlun JW (1996) Early pathogenesis of Listeria monocytogenes infection in the mouse spleen. J Med Microbiol 44:295–302

    Article  Google Scholar 

  • Crowley M, Inaba K, Steinman R (1990) Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J Exp Med 1990 172:383–386

    Article  PubMed  CAS  Google Scholar 

  • De Smedt T, Pajak B, Muraille E, et al. (1996) Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med 184:1413–1424

    Article  PubMed  Google Scholar 

  • Elbe A, Schleischitz S, Strunk D, Stingl G (1994) Fetal skin-derived MHC class I+, MHC class II- dendritic cells stimulate MHC class 1-restricted responses of unprimed CD8+ T cells. J Immunol 153:2878–2889

    PubMed  CAS  Google Scholar 

  • Everson MP, McDuffie DS, Lemak DG, Koopman WJ, McGhee JR, Beagley KW, et al. (1996) Dendritic cells from diiferent tissues induce production of different T cell cytokine profiles. J Leukoc Biol 1996 Apr, 59(4):494–498

    CAS  Google Scholar 

  • Fayette J, Dubois B, Vandenabeele S, Bridon JM, Vanbervliet B, Durand I, Banchereau J, Caux C, Briere F, et al. (1997) Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA 1 and IgA2. J Exp Med. 1997 Jun 2, 185(11): 1909–1918

    CAS  Google Scholar 

  • Filgueira L, Nestle FO, Rittig M, et al. (1996) Human dendritic cells phagocytose and process Borrelia burgdorferi. J Immunol 157:2998–3005

    PubMed  CAS  Google Scholar 

  • Finkelman FD, Lees A, Birnbaum R, et al. (1996) Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J Immunol 157:1406–1414

    PubMed  CAS  Google Scholar 

  • Frankel SS, Wenig BM, Burke AP, et al. (1996) Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. Science 272:115–117

    Article  PubMed  CAS  Google Scholar 

  • Godiska R, Chantry D, Raport CJ, et al. (1997) Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J Exp Med 185:1595–1604

    Article  PubMed  CAS  Google Scholar 

  • Gong JL, McCarthy KM, Telford J, et al. (1992) Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection. J Exp Med 175:797–807

    Article  PubMed  CAS  Google Scholar 

  • Grouard G, Rissoan MC, Filgueira L, el al. (1997) The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 185:1101–1111

    Article  PubMed  CAS  Google Scholar 

  • Guzman CA, Rohde M, Bock M, Timmis KN (1994) Invasion and intracellular survival of Bordetella bronchiseptica in mouse dendritic cells. Infect Immun 62:5528–5537

    PubMed  CAS  Google Scholar 

  • Guzman CA, Rohde M, Chakraborty T, et al. (1995) Interaction of Listeria monocytogenes with mouse dendritic cells. Infect Immun 63:3665–3673

    PubMed  CAS  Google Scholar 

  • Hamilton Easton A, Eichelberger M (1995) Virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected mice. J Virol 69:6359–6366

    Google Scholar 

  • Holt PG, Schon-Hegrad MA, Oliver J (1988) MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J Exp Med 167:262

    Article  PubMed  CAS  Google Scholar 

  • Holt PG, Schon-Hegrad MA, Philips MJ, McMenamin PG (1989) la-positive dendritic cells form a tightly meshed network within the human airway epithelium. Clin Exp Allergy 19:597–601

    Article  PubMed  CAS  Google Scholar 

  • Holt P, Schon HM, Oliver J, et al. (1990) A contiguous network of dendritic antigen presenting cells within the respiratory epithelium. Int Arch Allergy Appl Immunol 91:155–159

    Article  PubMed  CAS  Google Scholar 

  • Holt PG, Oliver J, Bilyk N, et al. (1993) Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 177:397–407

    Article  PubMed  CAS  Google Scholar 

  • Holt PG, Haining S, Nelson DJ, Sedgwick JD (1994) Origin and steady-state turnover of class II MHC- bearing dendritic cells in the epithelium of the conducting airways. J Immunol 153:256–261

    PubMed  CAS  Google Scholar 

  • Inaba K, Romani N, Steinman RM (1989) An antigen-independent contact mechanism as an early step in T cell-proliferative responses to dendritic cells. J Exp Med 170:527–542

    Article  PubMed  CAS  Google Scholar 

  • Inaba K, Inaba M, Naito M, Steinman RM (1993) Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med 178:479–488

    Article  PubMed  CAS  Google Scholar 

  • Janeway CA, Jr, Bottomly K (1994) Signals and signs for lymphocyte responses. Cell 76:275–285

    Article  PubMed  CAS  Google Scholar 

  • Kelsall BL, Strober W (1996) Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyefs patch. J Exp Med 183:237–247

    Article  PubMed  CAS  Google Scholar 

  • Kelsall BL, Stuber E, Neurath M, Strober W (1996) Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Thl T-cell responses. Ann N Y Acad Sci 795:116–126

    Article  PubMed  CAS  Google Scholar 

  • Kradin RL, Xia W, McCarthy K, Schneeberger EE (1993) FcR+/-subsets of Ia+ pulmonary dendritic cells in the rat display differences in their abilities to provide accessory co-stimulation for naive (OX-22+) and sensitized (OX-22-) T cells. Am J Pathol 142:811–819

    PubMed  CAS  Google Scholar 

  • Lanzavecchia A (1996) Mechanisms of antigen uptake for presentation. Curr Opin Immunol 8:348–354

    Article  PubMed  CAS  Google Scholar 

  • Lim SG, Condez A, Poulter LW, et al. (1993) Mucosal macrophage subsets of the gut in HIV: decrease in antigen-presenting cell phenotype. Clin Exp Immunol. 1993 Jun, 92(3):442–447

    Article  CAS  Google Scholar 

  • Liu LM, MacPherson GG(1991) Lymph-borne (veiled) dendritic cells can acquire and present intestinally administered antigens. Immunology 73:281–286

    PubMed  CAS  Google Scholar 

  • Liu LM, MacPherson GG (1993) Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo. J Exp Med 177:1299–1307

    Article  PubMed  CAS  Google Scholar 

  • Liu LM, MacPherson GG (1995a) Antigen processing: cultured lymph-borne dendritic cells can process and present native protein antigens. Immunology 84:241–246

    PubMed  CAS  Google Scholar 

  • Liu LM, MacPherson GG (1995b) Rat intestinal dendritic cells: immunostimulalory potency and phenotypic characterisation Immunology 85:88–93

    PubMed  CAS  Google Scholar 

  • Lu L, Bonham CA, Chambers FG, et al. (1996) Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis. J Immunol 157:3577–3586

    PubMed  CAS  Google Scholar 

  • Lutz MB, Granucci F, Winzler C, et al. (1994) Retroviral immortalization of phagocytic and dendritic cell clones as a tool to investigate functional heterogeneity. J Immunol Methods 174:269–279

    Article  PubMed  CAS  Google Scholar 

  • Macatonia SE, Knight SC, Edwards AJ, et al. (1987) Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies. J Exp Med 166:1654–1667

    Article  PubMed  CAS  Google Scholar 

  • MacPherson GG (1989) Properties of lymph-borne (veiled) dendritic cells in culture I Modulation of phenotype, survival and function: partial dependence on GM-CSF. Immunology 68:102–107

    PubMed  CAS  Google Scholar 

  • MacPherson GG, Possum S, Harrison B (1989) Properties of lymph-borne (veiled) dendritic cells in culture II. Expression of the IL-2 receptor: role of GM-CSF. Immunology 68:108–113

    PubMed  CAS  Google Scholar 

  • MacPherson GG, Jenkins CD, Stein MJ, Edwards C (1995) Endotoxin-mediated dendritic cell release from the intestine. Characterization of released dendritic cells and TNF dependence. J Immunol 154:1317–1322

    PubMed  CAS  Google Scholar 

  • Mahidu YR, Wu KC, Jewell DP (1988) Characterization of antigen-presenting activity of intestinal mononuclear cells isolated from normal and inflammatory bowel disease colon and ileum. Immunology 65:543–549

    Google Scholar 

  • Marie I, Holt PG, Perdue MH, Bienenstock J (1996) Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine. J Immunol 156:1408–1414

    Google Scholar 

  • Matzinger P (1994) Tolerance, danger, and the extended family. Annu Rev Immunol 12:991–1045

    Article  PubMed  CAS  Google Scholar 

  • Mayrhofer G, Holt PG, Papdimitriou JM (1986) Functional characteristics of the veiled cells in afferent lymph from the rat intestine. Immunology 58:379–387

    PubMed  CAS  Google Scholar 

  • McLeilan AD, Sorg RV, Williams LA, Hart DN (1996) Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand-dependent pathway. Eur J Immunol 26:1204–1210

    Article  Google Scholar 

  • McWilliam AS, Napoli S, Marsh AM, et al. (1996) Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli. J Exp Med 184:2429–2432

    Article  PubMed  CAS  Google Scholar 

  • Moll H, Flohe S, Rollinghoi T M (1995) Dendritic cells in Leishmania major-immune mice harbor persistent parasites and mediate an antigen-specific T cell immune response. Eur J Immunol 25:693–699

    Article  PubMed  CAS  Google Scholar 

  • Moll H, Fuchs H, Blank C, et al. (1993) Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. Eur J Immunol 23:1595–1601

    Article  PubMed  CAS  Google Scholar 

  • Norbury CC, Chambers BJ, Prescott AR, et al. (1997) Constitutive maeropinocytosis allows TAP-de- pendent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells. Eur J Immunol 27:280–288

    Article  PubMed  CAS  Google Scholar 

  • Pavli P, Woodhams C, Doe W, Hume D (1990) Isolation and characterization of antigen presenting dendritic cells from the mouse intestinal lamina propria. Immunology 70:40–47

    PubMed  CAS  Google Scholar 

  • Pavli P, Hume DA, van de Pol E, Doe WF (1993) Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria. Immunology 78:132–141

    PubMed  CAS  Google Scholar 

  • Pinehuk LM, Klaus SJ, Magaletti DM, et al. (1996) Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation. J Immunol 157:4363–4370

    Google Scholar 

  • Pope M, Betjes MG, Romani N, et al. (1994) Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 78:389–398

    Article  PubMed  CAS  Google Scholar 

  • Pope M, Gezelter S, Gallo N, et al. (1995) Low levels of HI V-1 infection in cutaneous dendritic cells promote extensive viral replication upon binding to memory CD4+ T cells. J Exp Med 182:2045–2056

    Article  PubMed  CAS  Google Scholar 

  • Pugh CW, MacPherson GG, Steer HW (1983) Characterization of nonlymphoid cells derived from rat peripheral lymph. J Exp Med 157:1758–1779

    Article  PubMed  CAS  Google Scholar 

  • Reis-e-Sousa C, Stahl PD, Austyn JM (1993) Phagocytosis of antigens by Langerhans cells in vitro. J Exp Med 178:509–519

    Article  PubMed  CAS  Google Scholar 

  • Rhodes JM (1985) Isolation of large mononuclear la-positive veiled cells from the mouse thoracic duct. J Immunol Methods 85:383–392

    Article  PubMed  CAS  Google Scholar 

  • Roake JA, Rao AS, Morris PJ, et al. (1995) Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J Exp Med 181:2237–2247

    Article  PubMed  CAS  Google Scholar 

  • Romani N, Koide S, Crowley M, et al. (1989) Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med 169:1169–1178

    Article  PubMed  CAS  Google Scholar 

  • Ruedl C, Rieser C, Bock G, et al. (1996) Phenotypic and functional characterization of CDllc+ dendritic cell population in mouse Peyer’s patches. Eur J Immunol 26:1801–1806

    Article  PubMed  CAS  Google Scholar 

  • Sallusto F, Lanzavecchia A (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179:1109–1118

    Article  PubMed  CAS  Google Scholar 

  • Sallusto F, Cella M, Danieli C, Lanzavecchia A (1995) Dendritic cells use macropinocytosis and the man nose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products (comments). J Exp Med 182:389–400

    Article  PubMed  CAS  Google Scholar 

  • Saunders D, Lucas K, Ismaili J, et al. (1996) Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor. J Exp Med 184:2185–2196

    Article  PubMed  CAS  Google Scholar 

  • Schuler G, Steinman RM (1985) Murine epidermal langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med 161:526–546

    Article  PubMed  CAS  Google Scholar 

  • Serti K, Takemura T, Tschachler E, et al. (1986) Dendritic cells with antigen presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura. J Exp Med 163:436

    Article  Google Scholar 

  • Spalding DM, Griffin JA (1986) Different pathways of differentiation of pre-B cell lines are induced by dendritic cells and T cells from different lymphoid tissues. Cell 44:507–515

    Article  PubMed  CAS  Google Scholar 

  • Spalding DM, Williamson SI, Koopman WJ, McGhee JR, et al. (1984) Preferential induction of polyclonal IgA secretion by murine Peyer’s patch dendritic cell-T cell mixtures. J Exp Med. 1984 Sep 1, 160(3):941–946

    Article  PubMed  CAS  Google Scholar 

  • Spinillo A, Tenti P, Zappatore R, De Seta F, Silini E, Guaschino S, et al. (1993) Langerhans cell counts and cervical intraepithelial neoplasia in women with human immunodeficiency virus infection. Gynecol Oncol. 1993 Feb, 48(2):210–213

    Article  PubMed  CAS  Google Scholar 

  • Spira AI, Marx PA, Patterson BK, et al. (1996) Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med 183:215–225

    Article  PubMed  CAS  Google Scholar 

  • Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271–296

    Article  PubMed  CAS  Google Scholar 

  • Steinman RM, Lustig DS, Cohn ZA (1974) Identification of a novel cell type in peripheral lymphoid organs of mice III. Functional properties in vivo. J Exp Med 139:1431–1435

    Article  PubMed  CAS  Google Scholar 

  • Strickland DH, Thepen T, Kees UR, et al. (1993) Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages. Immunology 80:266–272

    PubMed  CAS  Google Scholar 

  • Suss G, Shorlman K (1996) A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J Exp Med 183:1789–1796

    Article  PubMed  CAS  Google Scholar 

  • Tang A, Amagai M, Granger LG, et al. (1993) Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 361:82–85

    Article  PubMed  CAS  Google Scholar 

  • Thepen T, Van Rooijen N, Kraal G (1989) Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J Exp Med 170:499–509

    Article  PubMed  CAS  Google Scholar 

  • Thepen T, McMenamin C, Oliver J, et al. (1991) Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs immunity. Eur J Immunol 21:2845–2850

    Article  PubMed  CAS  Google Scholar 

  • Thepen T, Hoeben K, Breve J, Kraal G (1992) Alveolar macrophages down-regulate local pulmonary immune responses against intratracheally administered T-cell-dependent, but not T-cell-independent antigens. Immunology 76:60–64

    PubMed  CAS  Google Scholar 

  • Thepen T, Kraal G, Holt PG (1994) The role of alveolar macrophages in regulation of lung inflammation. Ann N Y Acad Sci 725:200–206

    Article  PubMed  CAS  Google Scholar 

  • van der Brugge-Gamelkoorn GJ, van de Ende MB, Sminia T (1985) Nonlymphoid cells of bronchus associated lymphoid tissue in the rat in situ and in suspension. With special reference to interdigitating and follicular dendritic cells. Cell Tissue Res 239:177

    Article  PubMed  Google Scholar 

  • Volkmann A, Neefjes J, Stockinger B (1996) A conditionally immortalized dendritic cell line which differentiates in contact with T cells or T cell-derived cytokines. Eur J Immunol 26:2565–2572

    Article  PubMed  CAS  Google Scholar 

  • Wu L, Li CL, Shortman K (1996) Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J Exp Med 184:903–911

    Article  PubMed  CAS  Google Scholar 

  • Xu S, Ariizumi K, Caceres Dittmar G, et al. (1995) Successive generation of antigen-presenting, dendritic cell lines from murine epidermis. J Immunol 154:2697–2705

    PubMed  CAS  Google Scholar 

  • Xu LL, Warren MK, Rose WL, et al. (1996) Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitro. J Leukoc Biol 60:365–371

    PubMed  CAS  Google Scholar 

  • Yolfey JM, Courtice C (1970) Lymphatics, lymph and the lymphomyeloid complex. Academic Press, New York, pp 548

    Google Scholar 

  • York IA, Rock KL (1996) Antigen processing and presentation by the class I major histocompatibility complex. Annu Rev Immunol 14:369–396

    Article  PubMed  CAS  Google Scholar 

  • Young JW, Steinman RM (1996) The hematopoietic development of dendritic cells: a distinct pathway for myeloid differentiation. Stem Cells 14:376–387

    Article  PubMed  CAS  Google Scholar 

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  1. L. M. Liu

    Present address: Center for Neurologic Diseases, Brigham and Woman’s Hospital, Harvard Medical School, 221 Longwood Ave., Boston, MA, 02115, USA

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  1. Sir William Dunn School of Pathology, Univeristy of Oxford, England

    G. G. MacPherson & L. M. Liu

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  1. Swiss Institute for Experimental Cancer Research Institute of Biochemistry, University of Lausanne, Ch. des Boveresses 155, CH-1066, Epalinges, Switzerland

    Jean-Pierre Kraehenbuhl

  2. GI Cell Biology Laboratory, Children’s Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA

    Marian R. Neutra

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MacPherson, G.G., Liu, L.M. (1999). Dendritic Cells and Langerhans Cells in the Uptake of Mucosal Antigens. In: Kraehenbuhl, JP., Neutra, M.R. (eds) Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines. Current Topics in Microbiology and Immunology, vol 236. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59951-4_3

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