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M Cells in Antigen Sampling in Mucosal Tissues

  • Chapter
Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 236))

Abstract

The mucosal surfaces of the gastrointestinal and respiratory tracts are lined by epithelial barriers composed of cells joined by tight junctions. These gasket-like junctional structures are generally effective in excluding peptides and macromolecules with antigenic potential (Madara et al. 1990). Mucosal surfaces are also provided with other defenses such as local secretions containing mucins and secretory immunoglobulin A (IgA) antibodies that tend to prevent antigens and pathogens from contacting the epithelium (Neutra et al. 1994). Nevertheless, to obtain samples from the external environment across this barrier, the mucosal immune system depends on a close collaboration between epithelial cells and antigen-presenting and lymphoid cells. These “lympho-epithelial complexes” allow transport of antigen samples across the mucosal barrier without compromising the integrity and protective functions of the epithelium.

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Authors and Affiliations

  1. Department of Pediatrics, Harvard Medical School, GI Cell Biology Laboratory, Enders 1220, Children’s Hospital, 300 Longwood Ave., Boston, MA, 02115, USA

    M. R. Neutra

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  1. Swiss Institute for Experimental Cancer Research Institute of Biochemistry, University of Lausanne, Ch. des Boveresses 155, CH-1066, Epalinges, Switzerland

    Jean-Pierre Kraehenbuhl

  2. GI Cell Biology Laboratory, Children’s Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA

    Marian R. Neutra

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Neutra, M.R. (1999). M Cells in Antigen Sampling in Mucosal Tissues. In: Kraehenbuhl, JP., Neutra, M.R. (eds) Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines. Current Topics in Microbiology and Immunology, vol 236. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59951-4_2

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