Skip to main content

Organization of Mucosal Lymphoid Tissue

  • Chapter

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 236))

Abstract

Mucous membranes form interfaces between internal microenvironments that are subject to homeostatic regulation and external environments that vary widely and are frequently contaminated with microbes and other potentially injurious agents. To offset their inherent vulnerability, mucosal surfaces have therefore been endowed with specialized defense mechanisms, many of which have an immune component.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adachi S, Yoshida H, Kataoka H, Nishikawa S-I (1997) Three distinctive steps in Peyer’s patch formation of murine embryo. Int Immunol 9:507–514

    Article  PubMed  CAS  Google Scholar 

  • Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, Luz A, Turetskaya RL, Tarakhovsky A, Rajewsky K, Nedospasov SA, Pfeffer K (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice. Proc Natl Acad Sci USA 94:9302–9307

    Article  PubMed  CAS  Google Scholar 

  • Banks TA, Rouse BT, Kerley MK, Blair PJ, Godfrey VL, Kuklin NA, Bouley DM, Thomas J, Kanangat S, Mucenski ML (1995) Lymphotoxin-α-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol 155:1685–1693

    Google Scholar 

  • De Togni P, Goellner J, Ruddle NH, Streeter PR, Fick A, Mariathasan S, Smith SC, Carlson R, Shornick LP, Strauss-Schoenberger J, Russell JH, Karr R, Chaplin DD (1994) Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264:703–707

    Article  PubMed  Google Scholar 

  • Erickson SL, de Sauvage FJ, Kikly K, Carver-Moore K, Pitts-Meek S, Gillett N, Sheehan KC, Schreiber RD, Goeddel DV, Moore MW (1994) Decreased sensitivity to tumour-necrosis factor but normal T- cell development in TNF receptor-2-deficient mice. Nature 372:560–563

    Article  PubMed  CAS  Google Scholar 

  • Griebel PJ, Ferrari G (1994) Evidence for a stromal cell-dependent, self-renewing B cell population lnlymphoid follicles of the ileal Peyer’s patch of sheep. Eur J Immunol 24:401–409

    Article  PubMed  CAS  Google Scholar 

  • Griebel PJ, Hein WR (1996) Expanding the role of Peyer’s patches in B-cell ontogeny. Immunol Today 17:30–39

    Article  PubMed  CAS  Google Scholar 

  • Kanamori Y, Ishimaru K, Nanno M, Maki K, Ikuta K, Nariuchi H, Ishikawa H (1996) Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thyl + lympho- hemopoietic progenitors develop. J Exp Med 184:1449–1459

    Article  PubMed  CAS  Google Scholar 

  • Kelsall BL, Strober W (1996) Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer’s patch. J Exp Med 183:237–247

    Article  PubMed  CAS  Google Scholar 

  • Kerneis S, Bogdanova A, Kraehenbuhl J-P, Pringault E (1997) Conversion by Peyer’s patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 277:949–952

    Article  PubMed  CAS  Google Scholar 

  • Kitamura Y (1989) Heterogeneity of mast cells and phenotypic change between subpopulations. Ann Rev Immunol 7:59–76

    Article  CAS  Google Scholar 

  • Landsverk T, Halleraker M, Aleksandersen M, McClure S, Hein W, Nicander L (1991) The intestinal habitat for organized lymphoid tissue in ruminants: comparative aspects of structure, function and development. Vet Immunol Immunopathol 28:1–16

    Article  PubMed  CAS  Google Scholar 

  • Lowden S, Heath T (1992) Lymph pathways associated with Peyer’s patches in sheep. J Anat 181:209- 217

    PubMed  Google Scholar 

  • Lowden S, Heath T (1994) Ileal Peyer’s patches in pigs: intercellular and lymphatic pathways. Anat Rec 239:297–305

    Article  PubMed  CAS  Google Scholar 

  • Lowden S, Heath T (1995) Lymphoid tissues of the ileum in young horses: distribution, structure and epithelium. Anat Embryol 192:171–179

    Article  PubMed  CAS  Google Scholar 

  • Lowden S, Heath T (1996) Lymph pathways associated with three types of follicle structure found in gut-associated lymphoid tissue of horse ileum. Anat Embryol 193:175–179

    Article  PubMed  CAS  Google Scholar 

  • Miyawaki S, Nakamura Y, Suzuka H, Koba M, Yasumizu R, Ikehara S, Shibata Y (1994) A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol 24:429–434

    Article  PubMed  CAS  Google Scholar 

  • Nanno M, Matsumoto S, Koike R, Miyasaka M, Kawaguchi M, Masuda T, Miyawaki S, Cai Z, Shimamura T, Fujiura Y, Ishikawa H (1994) Development of intestinal intraepithelial T lymphocytes is independent of Peyer’s patches and lymph nodes in aly mutant mice. J Immunol 153:2014–2020

    PubMed  CAS  Google Scholar 

  • Neumann B, Luz A, Pfeffer K, Holzmann B (1996) Defective Peyer’s patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J Exp Med 184:259–264

    Article  PubMed  CAS  Google Scholar 

  • Pabst R, Gehrke I (1990) Is the bronchus-associated lymphoid tissue (BALT) an integral structure of the lung in normal mammals, including humans? Am J Respir Cell Mol Biol 3:131–135

    PubMed  CAS  Google Scholar 

  • Pasparakis M, Alexopoulou L, Episkopou V, Kollias G (1996) Immune and inflammatory responses in TNFα-deficient mice: a critical requirement for TNFα in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184:1397–1411

    Article  PubMed  CAS  Google Scholar 

  • Pasparakis M, Alexopoulou L, Grell M, Pfizenmaier K, Bluethmann H, Kollias G (1997) Peyer’s patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. Proc Natl Acad Sci USA 94: 6319–6323 (see also Correction; 94:9510)

    Google Scholar 

  • Reynaud C-A, Mackay CR, Müller RG, Weill J-C (1991) Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer’s patches.Cell 64:995–1005

    Article  PubMed  CAS  Google Scholar 

  • Reynaud C-A, Garcia C, Hein WR, Weill J-C (1995) Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80:115–125

    Article  PubMed  CAS  Google Scholar 

  • Reynaud C-A, Dufour V, Weill J-C (1997) Generation of diversity in mammalian gut-associated lymphoid tissues. Restricted V gene usage does not preclude complex V gene organization.J Immunol 159:3093–3095

    Google Scholar 

  • Shanahan F (1997) A gut reaction: lymphoepithelial communication in the intestine. Science 275: 1897- 1898

    Article  PubMed  CAS  Google Scholar 

  • Spencer J, Macdonald TT, Finn T, Isaacson PG (1986) The development of gut associated lymphoid tissue in the terminal ileum of fetal human intestine. Clin Exp Immunol 64:536–543

    PubMed  CAS  Google Scholar 

  • Wang J, Whetsell M, Klein JR (1997) Local hormone networks and intestinal T cell homeostasis. Science 275:1937–1939

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hein, W.R. (1999). Organization of Mucosal Lymphoid Tissue. In: Kraehenbuhl, JP., Neutra, M.R. (eds) Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines. Current Topics in Microbiology and Immunology, vol 236. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59951-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59951-4_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64194-7

  • Online ISBN: 978-3-642-59951-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics