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Platelet Membrane Receptors and Signalling Pathways: New Therapeutic Targets

  • Chapter
Antithrombotics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 132))

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Abstract

Platelets circulate in the blood stream in a quiescent state but undergo explosive activation at sites of damage to the blood vessel wall, leading to formation of a haemostatic plug and cessation of bleeding. The quiescent state of the platelet is maintained in part by the inhibitory action of constitutively released nitric oxide from endothelial cells lining the blood vessels. Activation is brought about by contact with extracellular matrix proteins exposed at the site of tissue damage, notably collagen fibres, and is reinforced by release and generation of a large number of substances such as thrombin and thromboxanes. The remarkable number and diversity of these agents facilitates rapid formation of the platelet aggregate leading to arrest of bleeding. Activation of platelets within intact blood vessels, however, can lead to vascular occlusion with subsequent ischaemic tissue damage. In the most severe cases, this leads to myocardial infarction or stroke, two of the major causes of death in the Western world. The platelet, therefore, is a major target for therapeutic intervention in the prevention of thrombotic disease.

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Authors
  1. S. P. Watson
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  2. D. Keeling
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  3. M. D. Hollenberg
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Editors and Affiliations

  1. Drug Development, Parke-Davis Pharmaceutical Research Division, Warner-lambert Company, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA

    Andrew C. G. Uprichard M.D. (Vice President) (Vice President)

  2. Vascular and Cardiac Diseases, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA

    Kim P. Gallagher Ph.D.

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© 1999 Springer-Verlag Berlin Heidelberg

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Watson, S.P., Keeling, D., Hollenberg, M.D. (1999). Platelet Membrane Receptors and Signalling Pathways: New Therapeutic Targets. In: Uprichard, A.C.G., Gallagher, K.P. (eds) Antithrombotics. Handbook of Experimental Pharmacology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59942-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-59942-2_8

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