Zusammenfassung
Die pulmonale Hypertonie, d. h. die Erhöhung des pulmonalen Drucks in Ruhe > 20 mmHg und unter Belastung > 30 mmHg entsteht am häufigsten auf dem Boden einer chronischobstruktiven Bronchopneumopathie. Andere wichtige ätiologische Faktoren sind interstitielle Lungenerkrankungen, extrapulmonal bedingte hypoxämische Zustände, die primär pulmonale Hypertonie, chronische Lungenembolien und insbesondere sekundäre pulmonale Hypertonien bei erhöhtem linksventrikulärem Füllungsdruck.
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Literatur
L Abenhaim, Y Moride, F Brenot, St Rich, J Benichou, X Kurz, T Higenbrottam, C Oakley, E Wouters, M Aubie, G Simonneau, B Begaud (1996): Appetite-Suppressant Drugs and the risk of primary pulmonary hypertension. N Engl J Med 335:609–616
R A Asherson, M A Khammashta, J Ordi-Ros (1989) The primary antiphospholipid syndrome: major clinical and serologigcal features. Medicine (Baltimore) 68:366–374
R J Barst, L J Rubin, M D McGoon, E J Caldwell, W A Long, P S Levy (1994) Survival in Primary Pulmonary Hypertension with Long-Term continuous Intravenous Prostacyclin. Ann Intern med 121:409–415
R J Barst, L.J. Rubin, W A Long (1196) A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med 334: 296–301
J Beyne J (1942) Influence de l’anoxemie sur la grande circulation et sur la circulation pulonaire. CR Soc Biol 136:399–400
T Burke-Wolin, M S Wolin (1989): H 2 O 2 and cGMP may function as an O 2 sensor in the pulmonary artery. Appl Physiol 66:167–170
A Y Butt, T W Higenbottam, G Cremona, M Takao, C Glanville, A MacMahon (1993) Lack of acute pulmonary vasodilatation does not preclude successful clinical response to prostacyclin (Pg12) in severe pulmonary hypertension (Abs). Br. Heart J p 77
G A D’Alonzo, R J Barst, S M Ayres et al (1991) Survival in patients with primary pulmonary hypertension: results from a National Prospective Registry. Ann Intern Med 115:343–349
B F Dickey, A R Myers (1988) Pulmonary manifestations of collagen-vascular diseases. In: Fishman AP (ed) Pulmonary diseases and disorders. New York, Mc Graw-Hill, Vol. 2, Part 6:645–663
V Fuster, P M Steele, W D Edwards, B J Gersh, M D McGoon, R L Frye (1984) Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation 70/4:580–587
W Long, L J Rubin, R Barst, S Rich, D Badesch et al (1993) Randomized trial of conventional therapy alone vs conventional therapie + continuous infusions of prostacyclin in primary pulmonary hypertension: a 12 week study (abstract). Am Rev Respir Dis 147: A538
K M Moser, W R Auger, P F Fedullo (1990) Chronic major-vessel thromboembolic pulmonary hypertension. Circulation 81:1735–1743
Nocturnal Oxygen Therapy Trial Group (1980) Continuous or nocturnal oxygen thrapy in hypoxemic chrinic obstructive lung disease: a clinical trial. Ann Intern Med 93(3): 391–398
H Olschewski, D Walmrath, R Schermuly, A Ghofrani, F Grimminger, W Seeger (1996) Aerosolized Prostacyclin and lloprost in Severe Pulmonary Hypertension. Ann Intern Med 124:820–824
C H Orchard, R S de Leon, M K Sykes (1983) The relationship between hypoxic pulmonary vasoconstriction and arterial oxygen tension in intect dog. J Physiol 338:61–74
A Ourednik, Z Susa (1977) Prognose von Patienten mit pulmonaler Hypertension bei chronisch obstruktiven Lungenerkrankungen. Atemwegs Lungenkrankh 4:124
J A Parrakos, S J Aldestein, Re Smith, R D Rickmann, W Grossman, L Dexter, J E Dalen (1973) Late prognosis of acute pulmonary embolism. N Engl J Med 289:55–58
W Petro (1998) Sauerstoff-Langzeittherapie. Thieme, Stuttgart, New York
G G Pietra, W D Edwards, J M Kay, S Rich, J T Kernis et al (1989) Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Blood and Lung Institute, Primary Pulmonary Hypertension Registry. Circulation 80:1198–1206
B A Reitz, J I Wallwork, S A Hunt, J I Pennock, M E Billingham, P E Oyer et al (1982) Heart-lung transplantation. N Engl J Med 306:557–564
S Rich, D R Dantzker, S M Ayres, et al (1987) Primary pulmonary hypertension: a national prospective study. Ann Intern Med 107:216–223
S Rich, E Kaufmann, P S Levy (1992) The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med 327:76–81
S C Stuart-Harris, D C Flenley, J M Bishof, et al (1981) Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema: report of the Medical Research Council Working Party. Lancet 1(8222): 681–686
C A Wagenvoort, N Wagenvoort (1970) Primary pulmonary hypertension: A pathologic study of the lung vessels in 156 clinically diagnosed cases. Circulation 42:1163–1183
Hashida H, Hamada M, Shigematsu Y, Ikeda S, Kuwahara T, Kawakami H, Hara Y, Kodama K, Kohara K, Hiwada K (1998) Beneficial hemodynamic effects of oral prostacyclin (PGI2) analogue, beraprost sodium, on a patient with primary pulmonary hypertension — a case report. Angiology 49(2): 161–164
McLaughlin VV, Genthner DE, Panella MM, Rich S (1998) Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension (see comments). N Engl J Med 29;338(5):273–277
Palmer SM, Robinson LJ, Wang A, Gossage JR, Bashore T, Tapson VF (1998) Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary venoocclusive disease. Chest 113(1):237–240
Weir EK, Reeve HL, Huang JM, Michelakis E, Nelson DP, Hampl V, Archer SL (1996) Anorexic agents aminorex, fenfluramine and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation 94(9):2216–2220
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Beuckelmann, D.J. (1997). Pulmonale Hypertonie. In: Schuster, HP., Wilms, K., Lydtin, H., Lindner, U.K. (eds) Der Internist: Weiterbildung für Internisten Kardiologie/ Angiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59924-8_1
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DOI: https://doi.org/10.1007/978-3-642-59924-8_1
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