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Neurotrophin Treatment of Peripheral Sensory Neuropathies

  • Chapter
Neurotrophic Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 134))

Abstract

Peripheral sensory neuropathies result from many known etiologies, including diabetes and other metabolic disorders; toxicity from chemotherapeutic agents, such as taxol, cisplatin and vincristine; mechanical compression; ischemia; HIV and other viral infections; hereditary causes; and inflammatory and immune diseases. The etiology of some peripheral neuropathies remains obscure, despite thorough evaluations of the known causes; these are classified as idiopathic neuropathies. Diabetic polyneuropathy comprises the largest group of peripheral sensory neuropathies world-wide and, thus, is the targeted population in many ongoing clinical trials, including NGF. However, as will be illustrated below, neurotrophins, such as NGF, have the potential to be effective therapies for various types of peripheral sensory neuropathies, regardless of etiology.

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Abbreviations

ANS:

Autonomic nervous system

bFGF:

basic fibroblast growth factor

BDNF:

brain derived neurotrophic factor

CGRP:

calcitonin gene-related peptide

CNS:

central nervous system

CNTF:

ciliary neurotrophic factor

CMAP:

compound muscle action potential

CDT:

cooling detection threshold

DCCT:

Diabetes Control and Complications Trial Research Group

DM:

diabetes mellitus

DRG:

dorsal root ganglia

GDNF:

glial-derived neurotrophic factor

HB DB:

heart beat to deep breathing

HIV:

human immunodeficiency virus

LIF:

leukemia inhibitory factor

MTD:

maximum tolerated dose

MNCV:

motor nerve conduction velocity

MNDL:

motor nerve distal latency

NC:

nerve conduction

NGF:

nerve growth factor

NIS:

neuropathy impairment score

NIS-LL:

neuropathy impairment score for the lower limbs

NSP:

neuropathy symptom profile

NSC:

neuropathy symptoms and change

NPY:

neuropeptide Y

NTN:

neurturin

NT-3:

neurotrophin 3

NT-4/5:

neurotrophin 4/5

PNS:

peripheral nervous system

PD:

pharmacodynamic

rhNGF:

recombinant human nerve growth factor

RDNS:

Rochester Diabetic Neuropathy Study

SNAP:

sensory nerve action potential

STZ:

streptozotocin

SC:

subcutaneous

SCG:

superior cervical ganglion

TGF:

transforming growth factor

VIP:

vasoactive intestinal peptide

VDT:

vibratory detection threshold

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Authors
  1. C. A. Rask
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  2. E. Escandon
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Editors and Affiliations

  1. Merck Sharp & Dohme, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK

    Franz Hefti Ph.D.

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Rask, C.A., Escandon, E. (1999). Neurotrophin Treatment of Peripheral Sensory Neuropathies. In: Hefti, F. (eds) Neurotrophic Factors. Handbook of Experimental Pharmacology, vol 134. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59920-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-59920-0_3

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